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• W2606648897 abstract "<b><i>Background:</i></b> In sub-Saharan Africa, intense perennial <i>Plasmodium </i>species transmission coincides with areas of high prevalence of the human immunodeficiency virus type 1 (HIV) infection. This implies that antiretroviral naïve HIV-infected people living within these regions are repeatedly exposed to <i>Plasmodium</i> species infection and consequently malaria. Natural killer (NK) cells are known to contribute to malaria immunity through the production of IFN-&#x03B3; after exposure to <i>Plasmodium falciparum</i>-infected erythrocytes (infected red blood cells [iRBC]). However, in antiretroviral naïve HIV-1 infection, these functions could be impaired. In this study we assess the ability of NK cells from antiretroviral naïve HIV-1-infected people to respond to iRBC. <b><i>Method:</i></b> Magnetically sorted NK cells from antiretroviral naïve HIV-1-infected people were tested for their ability to respond to iRBC following in vitro coculture. NK cell IFN-&#x03B3; production after coculture was measured through multiparametric flow cytometry analysis. <b><i>Results:</i></b> Our data show a significant reduction (<i>p</i> = 0.03) in IFN-&#x03B3; production by NK cells from antiretroviral naïve HIV-1-infected people after coculture with iRBCs. This was in contrast to the NK cell response from healthy controls, which demonstrated elevated IFN-&#x03B3; production. NK cell IFN-&#x03B3; production from untreated HIV-1-infected participants correlated inversely with the viral load (<i>r</i> = -0.5, <i>p</i> = 0.02) and positively with total helper CD4⁺ T-cell count (<i>r</i> = 0.4, <i>p</i> = 0.04). Thus, antiretroviral naïve HIV-1 infection can dampen NK cell-mediated immunity to <i>P. falciparum</i> infection in malaria-intense regions. This could in effect escalate morbidity and mortality in people chronically infected with HIV-1." @default.
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• W2606648897 date "2017-04-21" @default.
• W2606648897 modified "2023-10-18" @default.
• W2606648897 title "The Effect of Antiretroviral Naïve HIV-1 Infection on the Ability of Natural Killer Cells to Produce IFN-γ upon Exposure to Plasmodium falciparum-Infected Erythrocytes" @default.
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• W2606648897 doi "https://doi.org/10.1159/000467386" @default.
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