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• W2606673189 abstract "// Maowen Ba 1, * , Guozhao Ma 2, * , Chao Ren 1 , Xuwen Sun 1 and Min Kong 3 1 Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao Medical University, Yantai 264000, Shandong, PR China 2 Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, Shandong, PR China 3 Department of Neurology, Yantaishan Hospital, Yantai City, Shandong 264000, PR China * These authors contributed equally to this work Correspondence to: Min Kong, email: kk_kmm@sina.com Xuwen Sun, email: sunxuwen@sohu.com Keywords: rTMS, Parkinson's disease, ubiquitin-proteasome system, dopamine, apoptosis Received: September 26, 2016      Accepted: April 11, 2017      Published: April 20, 2017 ABSTRACT The dysfunction of ubiquitin-proteasome system is an important pathogenesis in the neurodegenerative process of Parkinson's disease. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive and potential method in treating Parkinson's disease. To investigate whether rTMS has neuroprotective effects in parkinsonian rat model induced by ubiquitin-proteasome system impairment, we gave rTMS daily for 4 weeks to proteasome inhibitor, lactacystin-induced parkinsonian rat model. Rotational behavior test demonstrated that rTMS obviously reduced apomorphine-induced turning number in parkinsonian rats. rTMS could significantly alleviate the loss of tyrosine hydroxylase-positive dopaminergic neurons in lactacystin-lesioned substantia nigra and prevent the loss of striatal dopamine levels. Furthermore, rTMS also reduced the levels of apoptotic protein (cleaved caspase-3) and inflammatory factors (cyclooxygenase-2 and tumor necrosis factor alpha) in lesioned substantia nigra. These results suggest that rTMS can protect nigral dopaminergic neurons against the ubiquitin-proteasome system impairment-induced degeneration by anti-apoptotic and anti-inflammatory molecular mechanism." @default.
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• W2606673189 date "2017-04-20" @default.
• W2606673189 modified "2023-10-18" @default.
• W2606673189 title "Repetitive transcranial magnetic stimulation for treatment of lactacystin-induced Parkinsonian rat model" @default.
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• W2606673189 doi "https://doi.org/10.18632/oncotarget.17285" @default.
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