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- W2606677441 endingPage "1346" @default.
- W2606677441 startingPage "1338" @default.
- W2606677441 abstract "Signaling pathways are critical modulators of a variety of physiological and pathological processes, and the abnormal activation of some signaling pathways can contribute to disease progression in various conditions. As a result, signaling pathways have emerged as an important tool through which the occurrence and development of diseases can be studied, which may then lead to the development of novel drugs. Accumulating evidence supports a key role for extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in the embryonic development of the central nervous system (CNS) and in the regulation of adult brain function. ERK1/2, one of the most well characterized members of the mitogen-activated protein kinase family, regulates a range of processes, from metabolism, motility and inflammation, to cell death and survival. In the nervous system, ERK1/2 regulates synaptic plasticity, brain development and repair as well as memory formation. ERK1/2 is also a potent effector of neuronal death and neuroinflammation in many CNS diseases. This review summarizes recent findings in neurobiological ERK1/2 research, with a special emphasis on findings that clarify our understanding of the processes that regulate the plethora of isoform-specific ERK functions under physiological and pathological conditions. Finally, we suggest some potential therapeutic strategies associated with agents acting on the ERK1/2 signaling to prevent or treat neurological diseases." @default.
- W2606677441 created "2017-04-28" @default.
- W2606677441 creator A5047601323 @default.
- W2606677441 creator A5074882599 @default.
- W2606677441 date "2017-04-21" @default.
- W2606677441 modified "2023-10-17" @default.
- W2606677441 title "The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review)" @default.
- W2606677441 cites W139230957 @default.
- W2606677441 cites W1482498530 @default.
- W2606677441 cites W1534996404 @default.
- W2606677441 cites W1554441317 @default.
- W2606677441 cites W1561954310 @default.
- W2606677441 cites W1605394923 @default.
- W2606677441 cites W1608081470 @default.
- W2606677441 cites W1638203569 @default.
- W2606677441 cites W1782499902 @default.
- W2606677441 cites W1801803313 @default.
- W2606677441 cites W1851485572 @default.
- W2606677441 cites W1964486755 @default.
- W2606677441 cites W1967318257 @default.
- W2606677441 cites W1967348306 @default.
- W2606677441 cites W1967400782 @default.
- W2606677441 cites W1968666033 @default.
- W2606677441 cites W1968686966 @default.
- W2606677441 cites W1968862500 @default.
- W2606677441 cites W1973642840 @default.
- W2606677441 cites W1976097422 @default.
- W2606677441 cites W1976601848 @default.
- W2606677441 cites W1980379037 @default.
- W2606677441 cites W1982551997 @default.
- W2606677441 cites W1983946438 @default.
- W2606677441 cites W1984909573 @default.
- W2606677441 cites W1985389140 @default.
- W2606677441 cites W1988071883 @default.
- W2606677441 cites W1988264669 @default.
- W2606677441 cites W1990605258 @default.
- W2606677441 cites W1992103453 @default.
- W2606677441 cites W1994527362 @default.
- W2606677441 cites W1994799983 @default.
- W2606677441 cites W1996401008 @default.
- W2606677441 cites W1996886208 @default.
- W2606677441 cites W1998607921 @default.
- W2606677441 cites W1998784502 @default.
- W2606677441 cites W1998809668 @default.
- W2606677441 cites W1999401390 @default.
- W2606677441 cites W2001324348 @default.
- W2606677441 cites W2003476809 @default.
- W2606677441 cites W2004048845 @default.
- W2606677441 cites W2005026826 @default.
- W2606677441 cites W2009707997 @default.
- W2606677441 cites W2011046141 @default.
- W2606677441 cites W2011826559 @default.
- W2606677441 cites W2012303490 @default.
- W2606677441 cites W2013005759 @default.
- W2606677441 cites W2015592781 @default.
- W2606677441 cites W2018896819 @default.
- W2606677441 cites W2021852198 @default.
- W2606677441 cites W2022792702 @default.
- W2606677441 cites W2022831509 @default.
- W2606677441 cites W2023836268 @default.
- W2606677441 cites W2026489774 @default.
- W2606677441 cites W2031885286 @default.
- W2606677441 cites W2033092161 @default.
- W2606677441 cites W2035074539 @default.
- W2606677441 cites W2035079756 @default.
- W2606677441 cites W2035743526 @default.
- W2606677441 cites W2039397457 @default.
- W2606677441 cites W2041961889 @default.
- W2606677441 cites W2042017613 @default.
- W2606677441 cites W2042625441 @default.
- W2606677441 cites W2043085415 @default.
- W2606677441 cites W2043666766 @default.
- W2606677441 cites W2046431926 @default.
- W2606677441 cites W2050276749 @default.
- W2606677441 cites W2050726283 @default.
- W2606677441 cites W2052010199 @default.
- W2606677441 cites W2052203283 @default.
- W2606677441 cites W2053738369 @default.
- W2606677441 cites W2053993585 @default.
- W2606677441 cites W2054223500 @default.
- W2606677441 cites W2054946171 @default.
- W2606677441 cites W2056778738 @default.
- W2606677441 cites W2056924558 @default.
- W2606677441 cites W2061619331 @default.
- W2606677441 cites W2062289724 @default.
- W2606677441 cites W2064595948 @default.
- W2606677441 cites W2069482416 @default.
- W2606677441 cites W2071233994 @default.
- W2606677441 cites W2072126247 @default.
- W2606677441 cites W2072243374 @default.
- W2606677441 cites W2072993814 @default.
- W2606677441 cites W2074671154 @default.
- W2606677441 cites W2077358692 @default.
- W2606677441 cites W2077529232 @default.
- W2606677441 cites W2079311923 @default.
- W2606677441 cites W2081589139 @default.
- W2606677441 cites W2082455141 @default.
- W2606677441 cites W2084480427 @default.