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• W2606684181 abstract "TREK-2-like channels were identified on the basis of electrophysiological and pharmacological tests performed on freshly isolated and enzymatically/mechanically dispersed pyramidal neurons of the rat medial prefrontal cortex (mPFC). Single-channel currents were recorded in cell-attached configuration and the impact of adrenergic receptors (α1, α2, β) stimulation on spontaneously appearing TREK-2-like channel activity was tested. The obtained results indicate that noradrenaline decreases the mean open probability of TREK-2-like channel currents by activation of β1 but not of α1- and α2-adrenergic receptors. Mean open time and channel conductance were not affected. The system of intracellular signaling pathways depends on the activation of protein kinase A. We also show that adrenergic control of TREK-2-like channel currents by adrenergic receptors was similar in pyramidal neurons isolated from young, adolescent, and adult rats. Immunofluorescent confocal scans of mPFC slices confirmed the presence of the TREK-2 protein, which was abundant in layer V pyramidal neurons. The role of TREK-2-like channel control by adrenergic receptors is discussed." @default.
• W2606684181 created "2017-04-28" @default.
• W2606684181 creator A5006094666 @default.
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• W2606684181 date "2017-06-01" @default.
• W2606684181 modified "2023-09-26" @default.
• W2606684181 title "Kinetic properties and adrenergic control of TREK-2-like channels in rat medial prefrontal cortex (mPFC) pyramidal neurons" @default.
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• W2606684181 doi "https://doi.org/10.1016/j.brainres.2017.04.009" @default.
• W2606684181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28438532" @default.
• W2606684181 hasPublicationYear "2017" @default.
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