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- W2606744480 abstract "Abstract Objective To determine the effectiveness of therapy with the radiolabelled somatostatin analogs, 90Y-DOTATOC and 177Lu-DOTATATE, in the treatment of metastatic neuroendocrine tumors with progression to first-line treatment. Material and methods A study was conducted on 30 patients diagnosed with neuroendocrine tumors (gastroenteropancreatic, bronchopulmonary, MEN2A, MEN2B, phaeochromocytoma, and paraganglioma) with metastatic disease diagnosed by the pathology department, with progression to first-line treatment, and recruited from December 2014 to February 2016. Efficacy was analyzed using computed tomography (CT) according RECIST 1.1 criteria, and the molecular changes using the SUVmax of PET/CT with 68Ga-DOTATOC. Safety was carried out with a renal scan with 99mTc-MAG3. Results The 30 patients received a total of 49 cycles 90Y-DOTATOC (21 doses) and 177Lu-DOTATATE (28 doses), with a mean of 1.5 cycles per patient. Of these, 17 (56.7%) showed a partial morphological response, 22 (73.3%) molecular and biochemical response, and 23 (76.6%) clinical response. One patient died during the median follow-up of 13 months. The median overall survival from diagnosis was 54 months (95% CI; 31.18–76.81), and median progression-free survival was 32 months (95% CI; 15.00–48.99). Conclusion Therapy with 90Y-DOTATOC and 177Lu-DOTATATE is a promising therapy for patients with well and moderately differentiated neuroendocrine tumors. The efficacy is better the larger the number of cycles administered, inversely proportional to the number of metastases (" @default.
- W2606744480 created "2017-04-28" @default.
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- W2606744480 date "2017-05-01" @default.
- W2606744480 modified "2023-10-02" @default.
- W2606744480 title "Effectiveness of radiolabelled somatostatin analogs ( 90 Y-DOTATOC and 177 Lu-DOTATATE) in patients with metastatic neuroendocrine tumors: A single center experience in Mexico" @default.
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- W2606744480 doi "https://doi.org/10.1016/j.remnie.2017.01.007" @default.
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