Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606786998> ?p ?o ?g. }
- W2606786998 endingPage "515.e8" @default.
- W2606786998 startingPage "501" @default.
- W2606786998 abstract "Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification of suitable targets and optimal warheads. Here, we demonstrate that the cell-surface protein CD276/B7-H3 is broadly overexpressed by multiple tumor types on both cancer cells and tumor-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target. In preclinical studies CD276 ADCs armed with a conventional MMAE warhead destroyed CD276-positive cancer cells, but were ineffective against tumor vasculature. In contrast, pyrrolobenzodiazepine-conjugated CD276 ADCs killed both cancer cells and tumor vasculature, eradicating large established tumors and metastases, and improving long-term overall survival. CD276-targeted dual-compartment ablation could aid in the development of highly selective broad-acting anti-cancer therapies." @default.
- W2606786998 created "2017-04-28" @default.
- W2606786998 creator A5005215310 @default.
- W2606786998 creator A5016118775 @default.
- W2606786998 creator A5016178967 @default.
- W2606786998 creator A5017096462 @default.
- W2606786998 creator A5017815170 @default.
- W2606786998 creator A5017948966 @default.
- W2606786998 creator A5019647387 @default.
- W2606786998 creator A5020669365 @default.
- W2606786998 creator A5027332906 @default.
- W2606786998 creator A5029670581 @default.
- W2606786998 creator A5034916482 @default.
- W2606786998 creator A5037017528 @default.
- W2606786998 creator A5038794343 @default.
- W2606786998 creator A5041498573 @default.
- W2606786998 creator A5044767682 @default.
- W2606786998 creator A5050128204 @default.
- W2606786998 creator A5055104705 @default.
- W2606786998 creator A5063170825 @default.
- W2606786998 creator A5064653671 @default.
- W2606786998 creator A5066419207 @default.
- W2606786998 creator A5067443169 @default.
- W2606786998 creator A5068400345 @default.
- W2606786998 creator A5069265733 @default.
- W2606786998 creator A5075594448 @default.
- W2606786998 creator A5079271824 @default.
- W2606786998 creator A5089087939 @default.
- W2606786998 creator A5089862290 @default.
- W2606786998 date "2017-04-01" @default.
- W2606786998 modified "2023-10-17" @default.
- W2606786998 title "Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature" @default.
- W2606786998 cites W1566701354 @default.
- W2606786998 cites W1614553858 @default.
- W2606786998 cites W1758612015 @default.
- W2606786998 cites W1966339894 @default.
- W2606786998 cites W1978139448 @default.
- W2606786998 cites W1989481955 @default.
- W2606786998 cites W199166898 @default.
- W2606786998 cites W1995980049 @default.
- W2606786998 cites W1997099073 @default.
- W2606786998 cites W1998278019 @default.
- W2606786998 cites W1999416521 @default.
- W2606786998 cites W2005055996 @default.
- W2606786998 cites W2024078329 @default.
- W2606786998 cites W2026989399 @default.
- W2606786998 cites W2030249962 @default.
- W2606786998 cites W2052644931 @default.
- W2606786998 cites W2052768531 @default.
- W2606786998 cites W2056116866 @default.
- W2606786998 cites W2097229611 @default.
- W2606786998 cites W2104726756 @default.
- W2606786998 cites W2110943754 @default.
- W2606786998 cites W2117013761 @default.
- W2606786998 cites W2121934915 @default.
- W2606786998 cites W2132799399 @default.
- W2606786998 cites W2139036808 @default.
- W2606786998 cites W2141199885 @default.
- W2606786998 cites W2155977618 @default.
- W2606786998 cites W2156762984 @default.
- W2606786998 cites W2156873933 @default.
- W2606786998 cites W2158462290 @default.
- W2606786998 cites W2164617822 @default.
- W2606786998 cites W2168658644 @default.
- W2606786998 cites W2195425332 @default.
- W2606786998 cites W2288867196 @default.
- W2606786998 cites W2290311814 @default.
- W2606786998 cites W2312684437 @default.
- W2606786998 cites W2334067795 @default.
- W2606786998 cites W2341089209 @default.
- W2606786998 cites W2555713683 @default.
- W2606786998 cites W4252851641 @default.
- W2606786998 doi "https://doi.org/10.1016/j.ccell.2017.03.005" @default.
- W2606786998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5458750" @default.
- W2606786998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28399408" @default.
- W2606786998 hasPublicationYear "2017" @default.
- W2606786998 type Work @default.
- W2606786998 sameAs 2606786998 @default.
- W2606786998 citedByCount "251" @default.
- W2606786998 countsByYear W26067869982017 @default.
- W2606786998 countsByYear W26067869982018 @default.
- W2606786998 countsByYear W26067869982019 @default.
- W2606786998 countsByYear W26067869982020 @default.
- W2606786998 countsByYear W26067869982021 @default.
- W2606786998 countsByYear W26067869982022 @default.
- W2606786998 countsByYear W26067869982023 @default.
- W2606786998 crossrefType "journal-article" @default.
- W2606786998 hasAuthorship W2606786998A5005215310 @default.
- W2606786998 hasAuthorship W2606786998A5016118775 @default.
- W2606786998 hasAuthorship W2606786998A5016178967 @default.
- W2606786998 hasAuthorship W2606786998A5017096462 @default.
- W2606786998 hasAuthorship W2606786998A5017815170 @default.
- W2606786998 hasAuthorship W2606786998A5017948966 @default.
- W2606786998 hasAuthorship W2606786998A5019647387 @default.
- W2606786998 hasAuthorship W2606786998A5020669365 @default.
- W2606786998 hasAuthorship W2606786998A5027332906 @default.
- W2606786998 hasAuthorship W2606786998A5029670581 @default.
- W2606786998 hasAuthorship W2606786998A5034916482 @default.