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• W2606816583 abstract "Hydrolase-catalysed dynamic kinetic resolutions of chroman-2-ol and 3-methyl chroman-2-ol can be effected with up to 88% conversion and 92% ee through the use of organic solvents. Extension to the resolution of the tolterodine precursor 1 proved more challenging. The presence of the remote phenyl substituent had a significant impact on the resolution and it was not possible to achieve high enantioselectivity together with efficient conversion from the focussed panel of enzymes screened." @default.
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• W2606816583 date "2017-04-01" @default.
• W2606816583 modified "2023-09-26" @default.
• W2606816583 title "Hydrolase-mediated resolution of the hemiacetal in 2-chromanols: The impact of remote substitution" @default.
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• W2606816583 doi "https://doi.org/10.1016/j.tetasy.2017.04.001" @default.
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