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• W2606830876 endingPage "1090" @default.
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• W2606830876 abstract "The nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome has been implicated in podocyte injury and glomerular sclerosis during hyperhomocysteinemia (hHcys). However, it remains unclear whether the NLRP3 inflammasome can be a therapeutic target for treatment of hHcys-induced kidney injury. Given that DHA metabolites-resolvins have potent anti-inflammatory effects, the present study tested whether the prototype, resolvin D1 (RvD1), and 17S-hydroxy DHA (17S-HDHA), an intermediate product, abrogate hHcys-induced podocyte injury by targeting the NLRP3 inflammasome. In vitro, confocal microscopy demonstrated that 17S-HDHA (100 nM) and RvD1 (60 nM) prevented Hcys-induced formation of NLRP3 inflammasomes, as shown by reduced colocalization of NLRP3 with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) or caspase-1. Both DHA metabolites inhibited Hcys-induced caspase-1 activation and interleukin-1β production. However, DHA had no significant effect on these Hcys-induced changes in podocytes. In vivo, DHA lipoxygenase metabolites substantially inhibited podocyte NLRP3 inflammasome formation and activation and consequent glomerular sclerosis in mice with hHcys. Mechanistically, RvD1 and 17S-HDHA were shown to suppress Hcys-induced formation of lipid raft redox signaling platforms and subsequent O2·− production in podocytes. It is concluded that inhibition of NLRP3 inflammasome activation is one of the important mechanisms mediating the beneficial action of RvD1 and 17S-HDHA on Hcys-induced podocyte injury and glomerular sclerosis" @default.
• W2606830876 created "2017-04-28" @default.
• W2606830876 creator A5006586061 @default.
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• W2606830876 date "2017-06-01" @default.
• W2606830876 modified "2023-10-14" @default.
• W2606830876 title "NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury" @default.
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• W2606830876 cites W1666232996 @default.
• W2606830876 cites W1790743604 @default.
• W2606830876 cites W1928962200 @default.
• W2606830876 cites W1968222294 @default.
• W2606830876 cites W1970395996 @default.
• W2606830876 cites W1975430023 @default.
• W2606830876 cites W1980599171 @default.
• W2606830876 cites W1982002561 @default.
• W2606830876 cites W2013639621 @default.
• W2606830876 cites W2013907285 @default.
• W2606830876 cites W2014400002 @default.
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• W2606830876 cites W2019622883 @default.
• W2606830876 cites W2021446146 @default.
• W2606830876 cites W2041561635 @default.
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• W2606830876 cites W2048437702 @default.
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• W2606830876 cites W2053130016 @default.
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• W2606830876 cites W2107981126 @default.
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• W2606830876 doi "https://doi.org/10.1194/jlr.m072587" @default.
• W2606830876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5454504" @default.
• W2606830876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28404641" @default.
• W2606830876 hasPublicationYear "2017" @default.
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