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• W2606862276 abstract "Treatment of inflammatory bowel disease at present mainly targets mediators of inflammation to stop or suppress pro-inflammatory processes. Typical examples are steroids, suppression of T cells by thioguanine nucleotides, or antibodies against cytokines such as tumour necrosis factor, interleukin 12, or interleukin 23. In addition to suppression of inflammation, development of therapeutic strategies that support resolution of inflammation or that actively resolve inflammation might be desirable. Resolution of inflammation is now seen as an active process involving specific mediators (eg, lipid mediators or specific cytokines) that is mandatory to restore organ function and completely shut down inflammation. The molecular pathways involved in resolution of inflammation have been investigated in recent years and could be adopted in treatment strategies for inflammatory bowel disease. Among these approaches are anti-integrin strategies and means to produce or locally increase restitution or resolution factors, such as restoration of the activity of transforming growth factor-β by anti-SMAD7 antisense oligonucleotides. The potential role of inflammation-resolving lipid mediators (eg, resolvins), however, still warrants further study and clinical development. This Review focuses on the specific role of active resolution of inflammation in inflammatory bowel disease pathophysiology. Potential therapeutic targets based on these pathways are also discussed. Treatment of inflammatory bowel disease at present mainly targets mediators of inflammation to stop or suppress pro-inflammatory processes. Typical examples are steroids, suppression of T cells by thioguanine nucleotides, or antibodies against cytokines such as tumour necrosis factor, interleukin 12, or interleukin 23. In addition to suppression of inflammation, development of therapeutic strategies that support resolution of inflammation or that actively resolve inflammation might be desirable. Resolution of inflammation is now seen as an active process involving specific mediators (eg, lipid mediators or specific cytokines) that is mandatory to restore organ function and completely shut down inflammation. The molecular pathways involved in resolution of inflammation have been investigated in recent years and could be adopted in treatment strategies for inflammatory bowel disease. Among these approaches are anti-integrin strategies and means to produce or locally increase restitution or resolution factors, such as restoration of the activity of transforming growth factor-β by anti-SMAD7 antisense oligonucleotides. The potential role of inflammation-resolving lipid mediators (eg, resolvins), however, still warrants further study and clinical development. This Review focuses on the specific role of active resolution of inflammation in inflammatory bowel disease pathophysiology. Potential therapeutic targets based on these pathways are also discussed." @default.
• W2606862276 created "2017-04-28" @default.
• W2606862276 creator A5058012401 @default.
• W2606862276 date "2017-07-01" @default.
• W2606862276 modified "2023-09-29" @default.
• W2606862276 title "Resolution of inflammation in inflammatory bowel disease" @default.
• W2606862276 cites W1505827930 @default.
• W2606862276 cites W1544124240 @default.
• W2606862276 cites W1889359478 @default.
• W2606862276 cites W1890869106 @default.
• W2606862276 cites W1906353445 @default.
• W2606862276 cites W1968797543 @default.
• W2606862276 cites W1969507309 @default.
• W2606862276 cites W1971514874 @default.
• W2606862276 cites W1983600826 @default.
• W2606862276 cites W1984873885 @default.
• W2606862276 cites W1985100272 @default.
• W2606862276 cites W1985308079 @default.
• W2606862276 cites W1989110940 @default.
• W2606862276 cites W1989580445 @default.
• W2606862276 cites W1990014836 @default.
• W2606862276 cites W1991836246 @default.
• W2606862276 cites W1992955463 @default.
• W2606862276 cites W1995692313 @default.
• W2606862276 cites W1997188985 @default.
• W2606862276 cites W1997350408 @default.
• W2606862276 cites W2006522099 @default.
• W2606862276 cites W2007676096 @default.
• W2606862276 cites W2010203932 @default.
• W2606862276 cites W2010746507 @default.
• W2606862276 cites W2011361599 @default.
• W2606862276 cites W2011749939 @default.
• W2606862276 cites W2011885150 @default.
• W2606862276 cites W2013665866 @default.
• W2606862276 cites W2018707752 @default.
• W2606862276 cites W2019449356 @default.
• W2606862276 cites W2021239718 @default.
• W2606862276 cites W2022148879 @default.
• W2606862276 cites W2024172588 @default.
• W2606862276 cites W2029808921 @default.
• W2606862276 cites W2030672128 @default.
• W2606862276 cites W2036247850 @default.
• W2606862276 cites W2037231636 @default.
• W2606862276 cites W2038122919 @default.
• W2606862276 cites W2040761085 @default.
• W2606862276 cites W2047956396 @default.
• W2606862276 cites W2050362957 @default.
• W2606862276 cites W2050817202 @default.
• W2606862276 cites W2052463634 @default.
• W2606862276 cites W2053266223 @default.
• W2606862276 cites W2054493318 @default.
• W2606862276 cites W2059364985 @default.
• W2606862276 cites W2060254645 @default.
• W2606862276 cites W2062262876 @default.
• W2606862276 cites W2064365254 @default.
• W2606862276 cites W2067545795 @default.
• W2606862276 cites W2067659428 @default.
• W2606862276 cites W2068162195 @default.
• W2606862276 cites W2069147864 @default.
• W2606862276 cites W2069931076 @default.
• W2606862276 cites W2070360201 @default.
• W2606862276 cites W2077531651 @default.
• W2606862276 cites W2077653833 @default.
• W2606862276 cites W2079812792 @default.
• W2606862276 cites W2084743277 @default.
• W2606862276 cites W2085961304 @default.
• W2606862276 cites W2087971582 @default.
• W2606862276 cites W2088764647 @default.
• W2606862276 cites W2089176308 @default.
• W2606862276 cites W2092643186 @default.
• W2606862276 cites W2092744572 @default.
• W2606862276 cites W2093839463 @default.
• W2606862276 cites W2095792567 @default.
• W2606862276 cites W2096407919 @default.
• W2606862276 cites W2097187666 @default.
• W2606862276 cites W2097979070 @default.
• W2606862276 cites W2099129395 @default.
• W2606862276 cites W2099240520 @default.
• W2606862276 cites W2099599782 @default.
• W2606862276 cites W2101704737 @default.
• W2606862276 cites W2105058392 @default.
• W2606862276 cites W2106132036 @default.
• W2606862276 cites W2107128452 @default.
• W2606862276 cites W2108105670 @default.
• W2606862276 cites W2109138478 @default.
• W2606862276 cites W2110726506 @default.
• W2606862276 cites W2112082141 @default.
• W2606862276 cites W2112842079 @default.
• W2606862276 cites W2116432220 @default.
• W2606862276 cites W2117519175 @default.
• W2606862276 cites W2118688515 @default.
• W2606862276 cites W2120254551 @default.
• W2606862276 cites W2123590076 @default.
• W2606862276 cites W2124334818 @default.
• W2606862276 cites W2124502562 @default.
• W2606862276 cites W2125647281 @default.
• W2606862276 cites W2128175802 @default.
• W2606862276 cites W2129086067 @default.

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