Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606911785> ?p ?o ?g. }
- W2606911785 endingPage "R21" @default.
- W2606911785 startingPage "R1" @default.
- W2606911785 abstract "Fatty liver can be diet, endocrine, drug, virus or genetically induced. Independent of cause, hepatic lipid accumulation promotes systemic metabolic dysfunction. By acting as peroxisome proliferator-activated receptor (PPAR) ligands, hepatic non-esterified fatty acids upregulate expression of gluconeogenic, beta-oxidative, lipogenic and ketogenic genes, promoting hyperglycemia, hyperlipidemia and ketosis. The typical hormonal environment in fatty liver disease consists of hyperinsulinemia, hyperglucagonemia, hypercortisolemia, growth hormone deficiency and elevated sympathetic tone. These endocrine and metabolic changes further encourage hepatic steatosis by regulating adipose tissue lipolysis, liver lipid uptake, de novo lipogenesis (DNL), beta-oxidation, ketogenesis and lipid export. Hepatic lipid accumulation may be induced by 4 separate mechanisms: (1) increased hepatic uptake of circulating fatty acids, (2) increased hepatic de novo fatty acid synthesis, (3) decreased hepatic beta-oxidation and (4) decreased hepatic lipid export. This review will discuss the hormonal regulation of each mechanism comparing multiple physiological models of hepatic lipid accumulation. Nonalcoholic fatty liver disease (NAFLD) is typified by increased hepatic lipid uptake, synthesis, oxidation and export. Chronic hepatic lipid signaling through PPARgamma results in gene expression changes that allow concurrent activity of DNL and beta-oxidation. The importance of hepatic steatosis in driving systemic metabolic dysfunction is highlighted by the common endocrine and metabolic disturbances across many conditions that result in fatty liver. Understanding the mechanisms underlying the metabolic dysfunction that develops as a consequence of hepatic lipid accumulation is critical to identifying points of intervention in this increasingly prevalent disease state." @default.
- W2606911785 created "2017-04-28" @default.
- W2606911785 creator A5045854601 @default.
- W2606911785 creator A5081324818 @default.
- W2606911785 date "2017-07-01" @default.
- W2606911785 modified "2023-10-16" @default.
- W2606911785 title "Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones" @default.
- W2606911785 cites W1223465430 @default.
- W2606911785 cites W1523158326 @default.
- W2606911785 cites W1526348057 @default.
- W2606911785 cites W1558601380 @default.
- W2606911785 cites W1561098072 @default.
- W2606911785 cites W159276892 @default.
- W2606911785 cites W1609508996 @default.
- W2606911785 cites W1748636648 @default.
- W2606911785 cites W1792257846 @default.
- W2606911785 cites W1832095457 @default.
- W2606911785 cites W1881090086 @default.
- W2606911785 cites W1917568365 @default.
- W2606911785 cites W1963533730 @default.
- W2606911785 cites W1963645707 @default.
- W2606911785 cites W1964801445 @default.
- W2606911785 cites W1965572209 @default.
- W2606911785 cites W1965780112 @default.
- W2606911785 cites W1966872601 @default.
- W2606911785 cites W1967012020 @default.
- W2606911785 cites W1968853872 @default.
- W2606911785 cites W1971473415 @default.
- W2606911785 cites W1972587487 @default.
- W2606911785 cites W1973054372 @default.
- W2606911785 cites W1974794804 @default.
- W2606911785 cites W1975793873 @default.
- W2606911785 cites W1975884121 @default.
- W2606911785 cites W1975962309 @default.
- W2606911785 cites W1977020626 @default.
- W2606911785 cites W1978555135 @default.
- W2606911785 cites W1979383399 @default.
- W2606911785 cites W1979545505 @default.
- W2606911785 cites W1982126966 @default.
- W2606911785 cites W1982483611 @default.
- W2606911785 cites W1983076472 @default.
- W2606911785 cites W1983842819 @default.
- W2606911785 cites W1984371328 @default.
- W2606911785 cites W1984468543 @default.
- W2606911785 cites W1984525032 @default.
- W2606911785 cites W1984913749 @default.
- W2606911785 cites W1986273448 @default.
- W2606911785 cites W1986861420 @default.
- W2606911785 cites W1986914839 @default.
- W2606911785 cites W1990740519 @default.
- W2606911785 cites W1991642946 @default.
- W2606911785 cites W1992045051 @default.
- W2606911785 cites W1993577469 @default.
- W2606911785 cites W1994864081 @default.
- W2606911785 cites W1995030297 @default.
- W2606911785 cites W1995392322 @default.
- W2606911785 cites W1996821192 @default.
- W2606911785 cites W1997867553 @default.
- W2606911785 cites W1997917664 @default.
- W2606911785 cites W1998200002 @default.
- W2606911785 cites W1998244294 @default.
- W2606911785 cites W1998278776 @default.
- W2606911785 cites W2000787746 @default.
- W2606911785 cites W2002024809 @default.
- W2606911785 cites W2003376579 @default.
- W2606911785 cites W2003512116 @default.
- W2606911785 cites W2004644169 @default.
- W2606911785 cites W2005063766 @default.
- W2606911785 cites W2005478436 @default.
- W2606911785 cites W2006574739 @default.
- W2606911785 cites W2006862294 @default.
- W2606911785 cites W2007311885 @default.
- W2606911785 cites W2007887164 @default.
- W2606911785 cites W2009565165 @default.
- W2606911785 cites W2010120356 @default.
- W2606911785 cites W2010521423 @default.
- W2606911785 cites W2019700215 @default.
- W2606911785 cites W2022527085 @default.
- W2606911785 cites W2023451675 @default.
- W2606911785 cites W2023597944 @default.
- W2606911785 cites W2023947368 @default.
- W2606911785 cites W2025243241 @default.
- W2606911785 cites W2030859489 @default.
- W2606911785 cites W2031440577 @default.
- W2606911785 cites W2032129662 @default.
- W2606911785 cites W2034280561 @default.
- W2606911785 cites W2034651789 @default.
- W2606911785 cites W2035458523 @default.
- W2606911785 cites W2037154461 @default.
- W2606911785 cites W2039500834 @default.
- W2606911785 cites W2039827979 @default.
- W2606911785 cites W2040119973 @default.
- W2606911785 cites W2042074675 @default.
- W2606911785 cites W2042709372 @default.
- W2606911785 cites W2043002136 @default.
- W2606911785 cites W2043864088 @default.
- W2606911785 cites W2049315339 @default.
- W2606911785 cites W2049459573 @default.