FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2606965429> ?p ?o ?g. }

• W2606965429 endingPage "207" @default.
• W2606965429 startingPage "196" @default.
• W2606965429 abstract "The purpose of this research was to investigate the effectiveness of epidermal growth factor receptor (EGFR) targeted micelles loaded with IR-780 (Cetuximab/IR-780/micelles) for generating tumor targeting, multimodal images, and photothermal therapy (PTT). We initially studied the cellular uptake of these micelles using the HCT-116 and SW-620 cell lines. HCT-116 (high expression of EGFR) and SW-620 (low expression of EGFR) cell lines were used to examine biodistribution and antitumor effects of Cetuximab/IR-780/micelles. Time-lapse near-IR fluorescence (NIRF) images also indicated the highest IR-780 accumulation from Cetuximab/IR-780/micelles in HCT-116 tumors (p < 0.05). HCT-116 tumors in tumor-bearing mice exhibited significantly higher accumulations of Cetuximab/IR-780/111In-micelles than SW-620 tumors in Micro-SPECT/CT imaging and biodistribution studies (p < 0.05). Dual-radioisotope Nano-SPECT/CT imaging of Cetuximab/131I-IR-780/111In-micelles demonstrated simultaneous high accumulation of both IR-780 and micelles in HCT-116 tumors, but not in SW-620 tumors. Regarding antitumor effects, following the Cetuximab/IR-780/micelles with PPT on day 6, all HCT-116 tumor-bearing mice were cured. In contrast, SW-620 tumors relapsed at 13 days after treatment. In summary, we expect that the Cetuximab/IR-780/micelles could enhance the antitumor effects by PTT in EGFR overexpression colorectal cancers through effective drug delivery nanoparticles." @default.
• W2606965429 created "2017-04-28" @default.
• W2606965429 creator A5000930977 @default.
• W2606965429 creator A5013637396 @default.
• W2606965429 creator A5018073164 @default.
• W2606965429 creator A5020504197 @default.
• W2606965429 creator A5030467912 @default.
• W2606965429 creator A5033933073 @default.
• W2606965429 creator A5052233668 @default.
• W2606965429 date "2017-07-01" @default.
• W2606965429 modified "2023-10-11" @default.
• W2606965429 title "EGFR-targeted micelles containing near-infrared dye for enhanced photothermal therapy in colorectal cancer" @default.
• W2606965429 cites W1235656097 @default.
• W2606965429 cites W1767611922 @default.
• W2606965429 cites W1885842150 @default.
• W2606965429 cites W1964086531 @default.
• W2606965429 cites W1980478558 @default.
• W2606965429 cites W1989545341 @default.
• W2606965429 cites W1992588670 @default.
• W2606965429 cites W1994023367 @default.
• W2606965429 cites W1996076368 @default.
• W2606965429 cites W1998988909 @default.
• W2606965429 cites W2002380174 @default.
• W2606965429 cites W2002516695 @default.
• W2606965429 cites W2014307717 @default.
• W2606965429 cites W2017200231 @default.
• W2606965429 cites W2024100029 @default.
• W2606965429 cites W2027910328 @default.
• W2606965429 cites W2029682365 @default.
• W2606965429 cites W2034424057 @default.
• W2606965429 cites W2051444430 @default.
• W2606965429 cites W2061672022 @default.
• W2606965429 cites W2063010667 @default.
• W2606965429 cites W2063242571 @default.
• W2606965429 cites W2064465745 @default.
• W2606965429 cites W2077366285 @default.
• W2606965429 cites W2078805504 @default.
• W2606965429 cites W2081813848 @default.
• W2606965429 cites W2085745775 @default.
• W2606965429 cites W2093860844 @default.
• W2606965429 cites W2095021205 @default.
• W2606965429 cites W2102338067 @default.
• W2606965429 cites W2123166905 @default.
• W2606965429 cites W2130940502 @default.
• W2606965429 cites W2167461110 @default.
• W2606965429 cites W2219053479 @default.
• W2606965429 cites W4246015058 @default.
• W2606965429 cites W4253436240 @default.
• W2606965429 cites W891668015 @default.
• W2606965429 doi "https://doi.org/10.1016/j.jconrel.2017.04.031" @default.
• W2606965429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28445743" @default.
• W2606965429 hasPublicationYear "2017" @default.
• W2606965429 type Work @default.
• W2606965429 sameAs 2606965429 @default.
• W2606965429 citedByCount "41" @default.
• W2606965429 countsByYear W26069654292017 @default.
• W2606965429 countsByYear W26069654292018 @default.
• W2606965429 countsByYear W26069654292019 @default.
• W2606965429 countsByYear W26069654292020 @default.
• W2606965429 countsByYear W26069654292021 @default.
• W2606965429 countsByYear W26069654292022 @default.
• W2606965429 countsByYear W26069654292023 @default.
• W2606965429 crossrefType "journal-article" @default.
• W2606965429 hasAuthorship W2606965429A5000930977 @default.
• W2606965429 hasAuthorship W2606965429A5013637396 @default.
• W2606965429 hasAuthorship W2606965429A5018073164 @default.
• W2606965429 hasAuthorship W2606965429A5020504197 @default.
• W2606965429 hasAuthorship W2606965429A5030467912 @default.
• W2606965429 hasAuthorship W2606965429A5033933073 @default.
• W2606965429 hasAuthorship W2606965429A5052233668 @default.
• W2606965429 hasConcept C11268172 @default.
• W2606965429 hasConcept C121608353 @default.
• W2606965429 hasConcept C126322002 @default.
• W2606965429 hasConcept C147789679 @default.
• W2606965429 hasConcept C171250308 @default.
• W2606965429 hasConcept C182606246 @default.
• W2606965429 hasConcept C184651966 @default.
• W2606965429 hasConcept C185592680 @default.
• W2606965429 hasConcept C192562407 @default.
• W2606965429 hasConcept C202751555 @default.
• W2606965429 hasConcept C2777807558 @default.
• W2606965429 hasConcept C2779438470 @default.
• W2606965429 hasConcept C2779998722 @default.
• W2606965429 hasConcept C502942594 @default.
• W2606965429 hasConcept C526805850 @default.
• W2606965429 hasConcept C55493867 @default.
• W2606965429 hasConcept C71924100 @default.
• W2606965429 hasConceptScore W2606965429C11268172 @default.
• W2606965429 hasConceptScore W2606965429C121608353 @default.
• W2606965429 hasConceptScore W2606965429C126322002 @default.
• W2606965429 hasConceptScore W2606965429C147789679 @default.
• W2606965429 hasConceptScore W2606965429C171250308 @default.
• W2606965429 hasConceptScore W2606965429C182606246 @default.
• W2606965429 hasConceptScore W2606965429C184651966 @default.
• W2606965429 hasConceptScore W2606965429C185592680 @default.
• W2606965429 hasConceptScore W2606965429C192562407 @default.
• W2606965429 hasConceptScore W2606965429C202751555 @default.
• W2606965429 hasConceptScore W2606965429C2777807558 @default.

• next