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- W2606987399 abstract "In the previous paper by the same author the nucleic acid metabolism in some organs which was infected by Japanese B Encephalitis was studied by Schneider's method. Some detailed study by Schmidt & Thanhauser's method on this problem was further undertook and is going to be reported here.P32 was used as the tracer throughout this investigation and was injected intraperitoneally into the mice at the acme stage of infection.After the time intervals of 6 and 24 hours were collected certain quantities of brain, which were then fractionated by Schmidt & Thanhauser's method into DNH- and RNA- fractionsThese nucleic acid fractions were investigated on their P32 contents.By comparing the results with those obtained from the control references made by treating the healthy mice with P32 in the same way, an increase in P32-activity was recognized at the DNA-fraction of the brain, this indicating the fact that, when mouse is infected with the virus, the DNA-fraction of the brain suffers a marked change.Similar investigation was also carried out at the incubation period.In this case, however, an increase in the P32-activity was observed at the DNA and PNA-fraction of the liver collected from the mice infected with the virus. It is fully interesting that this increase in P32-activity shows intimate accordance with the visceral phase of the disease." @default.
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- W2606987399 date "1955-01-01" @default.
- W2606987399 modified "2023-10-17" @default.
- W2606987399 title "EXPERIMENTAL STUDIES ON JAPANESE B ENCEPHALITIS WITH THE RADIOACTIVE P<sup>32</sup>" @default.
- W2606987399 doi "https://doi.org/10.4044/joma1947.67.5_961" @default.
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