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• W26070129 abstract "The fundamental characteristic of the centrosome is that it embodies the major microtubule organizing center (MTOC) of the cell. The centrosome determines the number and polarity of cytoplasmic microtubules. This chapter focuses on the centrosome defects seen in malignant tumors and the role that they play in tumor progression. Centrosomes are involved with cancer in two possible ways. The first is through disruption of their function as the poles of the bipolar mitotic spindle apparatus. Centrosome defects that increase the chances of improper chromosome segregation during mitosis result in aneuploidy and lead to tumor progression. These defects include amplification of both the number and the size of centrosomes, hyperphosphorylation of centrosomal proteins, and an increase in their microtubule nucleating capacity. Centrosome-associated kinases and tumor suppressor proteins such as p53 and BRCA1 may be involved in regulating the transition of the centrosome from its interphase function to its mitotic function. Mutations in tumor suppressor genes and perturbations to the centrosome-associated kinase activities cause the centrosome defects that lead to aneuploidy. Centrosomes may also be involved in cancer through their role in establishing and maintaining cell, and therefore tissue, polarity." @default.
• W26070129 created "2016-06-24" @default.
• W26070129 creator A5002659990 @default.
• W26070129 creator A5029305787 @default.
• W26070129 date "1999-01-01" @default.
• W26070129 modified "2023-10-17" @default.
• W26070129 title "The role of the centrosome in the development of malignant tumors" @default.
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• W26070129 doi "https://doi.org/10.1016/s0070-2153(99)49015-5" @default.
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• W26070129 hasPublicationYear "1999" @default.
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