Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607014367> ?p ?o ?g. }
- W2607014367 endingPage "1940" @default.
- W2607014367 startingPage "1933" @default.
- W2607014367 abstract "In this study, a novel chemotherapy drug-free DNA nanocomplex composed of three therapeutic aptamers (IDA, AS1411 and apMNK2F) was designed for treatment of cancer cells. For MTT assay, PC-3 and 4T1 cells (target cells) and CHO cells (nontarget cells) were treated with apMNK2F-AS1411-IDA complex (DNA nanocomplex), as well as AS1411, IDA and apMNK2F alone. Internalization of apMNK2F-AS1411-IDA complex was analyzed by fluorescence imaging and flow cytometry analysis. In the last step, the presented DNA nanocomplex was applied for prohibition of tumor growth in vivo. The results of internalization assay verified that the developed apMNK2F-AS1411-IDA complex was remarkably internalized into PC-3 and 4T1 cells, but not into CHO cells. The results of internalization assay was confirmed by MTT assay. apMNK2F-AS1411-IDA complex was more cytotoxic in PC-3 and 4T1 cells (target) and less cytotoxic in CHO cells (nontarget). Also, the DNA nanocomplex could effectively suppress the growth of tumors in vivo." @default.
- W2607014367 created "2017-04-28" @default.
- W2607014367 creator A5006264741 @default.
- W2607014367 creator A5015103898 @default.
- W2607014367 creator A5039331205 @default.
- W2607014367 creator A5049264762 @default.
- W2607014367 creator A5066655870 @default.
- W2607014367 creator A5072487912 @default.
- W2607014367 date "2017-08-01" @default.
- W2607014367 modified "2023-10-03" @default.
- W2607014367 title "A novel chemotherapy drug-free delivery system composed of three therapeutic aptamers for the treatment of prostate and breast cancers in vitro and in vivo" @default.
- W2607014367 cites W1538122875 @default.
- W2607014367 cites W1540332185 @default.
- W2607014367 cites W1804398254 @default.
- W2607014367 cites W1985290031 @default.
- W2607014367 cites W1987835529 @default.
- W2607014367 cites W2005498917 @default.
- W2607014367 cites W2038146634 @default.
- W2607014367 cites W2041919391 @default.
- W2607014367 cites W2043915025 @default.
- W2607014367 cites W2051620208 @default.
- W2607014367 cites W2106819793 @default.
- W2607014367 cites W2221585326 @default.
- W2607014367 cites W2225075140 @default.
- W2607014367 cites W2296852443 @default.
- W2607014367 cites W2298595881 @default.
- W2607014367 cites W2300311837 @default.
- W2607014367 cites W2304776379 @default.
- W2607014367 cites W2319397249 @default.
- W2607014367 cites W2322232806 @default.
- W2607014367 cites W2324393204 @default.
- W2607014367 cites W2339226501 @default.
- W2607014367 cites W2339832393 @default.
- W2607014367 cites W2339978775 @default.
- W2607014367 cites W2345952503 @default.
- W2607014367 cites W2368013889 @default.
- W2607014367 cites W2397764170 @default.
- W2607014367 cites W2409505837 @default.
- W2607014367 cites W2414386149 @default.
- W2607014367 cites W2416705229 @default.
- W2607014367 cites W2460088248 @default.
- W2607014367 cites W2470610043 @default.
- W2607014367 cites W2478803149 @default.
- W2607014367 cites W2504217493 @default.
- W2607014367 cites W2508356124 @default.
- W2607014367 cites W2513772155 @default.
- W2607014367 doi "https://doi.org/10.1016/j.nano.2017.04.002" @default.
- W2607014367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28414074" @default.
- W2607014367 hasPublicationYear "2017" @default.
- W2607014367 type Work @default.
- W2607014367 sameAs 2607014367 @default.
- W2607014367 citedByCount "18" @default.
- W2607014367 countsByYear W26070143672018 @default.
- W2607014367 countsByYear W26070143672019 @default.
- W2607014367 countsByYear W26070143672020 @default.
- W2607014367 countsByYear W26070143672021 @default.
- W2607014367 countsByYear W26070143672022 @default.
- W2607014367 countsByYear W26070143672023 @default.
- W2607014367 crossrefType "journal-article" @default.
- W2607014367 hasAuthorship W2607014367A5006264741 @default.
- W2607014367 hasAuthorship W2607014367A5015103898 @default.
- W2607014367 hasAuthorship W2607014367A5039331205 @default.
- W2607014367 hasAuthorship W2607014367A5049264762 @default.
- W2607014367 hasAuthorship W2607014367A5066655870 @default.
- W2607014367 hasAuthorship W2607014367A5072487912 @default.
- W2607014367 hasConcept C121608353 @default.
- W2607014367 hasConcept C128972844 @default.
- W2607014367 hasConcept C139770010 @default.
- W2607014367 hasConcept C1491633281 @default.
- W2607014367 hasConcept C150903083 @default.
- W2607014367 hasConcept C153911025 @default.
- W2607014367 hasConcept C154317977 @default.
- W2607014367 hasConcept C178790620 @default.
- W2607014367 hasConcept C185592680 @default.
- W2607014367 hasConcept C202751555 @default.
- W2607014367 hasConcept C207001950 @default.
- W2607014367 hasConcept C2779820397 @default.
- W2607014367 hasConcept C2780783641 @default.
- W2607014367 hasConcept C502942594 @default.
- W2607014367 hasConcept C54355233 @default.
- W2607014367 hasConcept C553184892 @default.
- W2607014367 hasConcept C55493867 @default.
- W2607014367 hasConcept C86803240 @default.
- W2607014367 hasConcept C96232424 @default.
- W2607014367 hasConceptScore W2607014367C121608353 @default.
- W2607014367 hasConceptScore W2607014367C128972844 @default.
- W2607014367 hasConceptScore W2607014367C139770010 @default.
- W2607014367 hasConceptScore W2607014367C1491633281 @default.
- W2607014367 hasConceptScore W2607014367C150903083 @default.
- W2607014367 hasConceptScore W2607014367C153911025 @default.
- W2607014367 hasConceptScore W2607014367C154317977 @default.
- W2607014367 hasConceptScore W2607014367C178790620 @default.
- W2607014367 hasConceptScore W2607014367C185592680 @default.
- W2607014367 hasConceptScore W2607014367C202751555 @default.
- W2607014367 hasConceptScore W2607014367C207001950 @default.
- W2607014367 hasConceptScore W2607014367C2779820397 @default.
- W2607014367 hasConceptScore W2607014367C2780783641 @default.
- W2607014367 hasConceptScore W2607014367C502942594 @default.