FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607044548> ?p ?o ?g. }

• W2607044548 abstract "The way in which the information contained in genotypes is translated into complex phenotypic traits (i.e. embryonic expression patterns) depends on its decoding by a multilayered hierarchy of biomolecular systems (regulatory networks). Each layer of this hierarchy displays its own regulatory schemes (i.e. operational rules such as +/2 feedback) and associated control parameters, resulting in characteristic variational constraints. This process can be conceptualized as a mapping issue, and in the context of highly-dimensional genotype-phenotype mappings (GPMs) epistatic events have been shown to be ubiquitous, manifested in non-linear correspondences between changes in the genotype and their phenotypic effects. In this study I concentrate on epistatic phenomena pervading levels of biological organization above the genetic material, more specifically the realm of molecular networks. At this level, systems approaches to studying GPMs are specially suitable to shed light on the mechanistic basis of epistatic phenomena. To this aim, I constructed and analyzed ensembles of highlymodular (fully interconnected) networks with distinctive topologies, each displaying dynamic behaviors that were categorized as either arbitrary or functional according to early patterning processes in the Drosophila embryo. Spatiotemporal expression trajectories in virtual syncytial embryos were simulated via reaction-diffusion models. My in silico mutational experiments show that: 1) the average fitness decay tendency to successively accumulated mutations in ensembles of functional networks indicates the prevalence of positive epistasis, whereas in ensembles of arbitrary networks negative epistasis is the dominant tendency; and 2) the evaluation of epistatic coefficients of diverse interaction orders indicates that, both positive and negative epistasis are more prevalent in functional networks than in arbitrary ones. Overall, I conclude that the phenotypic and fitness effects of multiple perturbations are strongly conditioned by both the regulatory architecture (i.e. pattern of coupled feedback structures) and the dynamic nature of the spatio-temporal expression trajectories displayed by the simulated networks." @default.
• W2607044548 created "2017-04-28" @default.
• W2607044548 creator A5070168109 @default.
• W2607044548 date "2009-01-01" @default.
• W2607044548 modified "2023-09-24" @default.
• W2607044548 title "A Developmental Systems Perspective on Epistasis: Computational Exploration of Mutational Interactions in Model Developmental Regulatory Networks" @default.
• W2607044548 cites W1551586941 @default.
• W2607044548 cites W1565578508 @default.
• W2607044548 cites W1602132379 @default.
• W2607044548 cites W1964525882 @default.
• W2607044548 cites W1979753811 @default.
• W2607044548 cites W1981704956 @default.
• W2607044548 cites W1983567190 @default.
• W2607044548 cites W1987815409 @default.
• W2607044548 cites W1991138583 @default.
• W2607044548 cites W1999944340 @default.
• W2607044548 cites W2004278386 @default.
• W2607044548 cites W2007669896 @default.
• W2607044548 cites W2013128939 @default.
• W2607044548 cites W2021793145 @default.
• W2607044548 cites W2023518751 @default.
• W2607044548 cites W2035300844 @default.
• W2607044548 cites W2037594820 @default.
• W2607044548 cites W2039813668 @default.
• W2607044548 cites W2046242662 @default.
• W2607044548 cites W2055122486 @default.
• W2607044548 cites W2057414337 @default.
• W2607044548 cites W2058186423 @default.
• W2607044548 cites W2060915805 @default.
• W2607044548 cites W2061425021 @default.
• W2607044548 cites W2066520145 @default.
• W2607044548 cites W2072353637 @default.
• W2607044548 cites W2073881372 @default.
• W2607044548 cites W2081146885 @default.
• W2607044548 cites W2083034544 @default.
• W2607044548 cites W2094189284 @default.
• W2607044548 cites W2098501743 @default.
• W2607044548 cites W2105561568 @default.
• W2607044548 cites W2106807044 @default.
• W2607044548 cites W2111011458 @default.
• W2607044548 cites W2111857816 @default.
• W2607044548 cites W2117056464 @default.
• W2607044548 cites W2120061771 @default.
• W2607044548 cites W2121663178 @default.
• W2607044548 cites W2124501045 @default.
• W2607044548 cites W2125876684 @default.
• W2607044548 cites W2128855005 @default.
• W2607044548 cites W2135698413 @default.
• W2607044548 cites W2142072523 @default.
• W2607044548 cites W2142685737 @default.
• W2607044548 cites W2145953174 @default.
• W2607044548 cites W2150749732 @default.
• W2607044548 cites W2153904514 @default.
• W2607044548 cites W2161297153 @default.
• W2607044548 cites W2164375995 @default.
• W2607044548 cites W2166012954 @default.
• W2607044548 cites W2167415035 @default.
• W2607044548 cites W2173492600 @default.
• W2607044548 cites W2303043072 @default.
• W2607044548 cites W97482554 @default.
• W2607044548 cites W2156469654 @default.
• W2607044548 hasPublicationYear "2009" @default.
• W2607044548 type Work @default.
• W2607044548 sameAs 2607044548 @default.
• W2607044548 citedByCount "0" @default.
• W2607044548 crossrefType "journal-article" @default.
• W2607044548 hasAuthorship W2607044548A5070168109 @default.
• W2607044548 hasConcept C104317684 @default.
• W2607044548 hasConcept C111472728 @default.
• W2607044548 hasConcept C127716648 @default.
• W2607044548 hasConcept C138885662 @default.
• W2607044548 hasConcept C142853389 @default.
• W2607044548 hasConcept C151730666 @default.
• W2607044548 hasConcept C162324750 @default.
• W2607044548 hasConcept C2775905019 @default.
• W2607044548 hasConcept C2779343474 @default.
• W2607044548 hasConcept C31170391 @default.
• W2607044548 hasConcept C34447519 @default.
• W2607044548 hasConcept C41008148 @default.
• W2607044548 hasConcept C54355233 @default.
• W2607044548 hasConcept C61727976 @default.
• W2607044548 hasConcept C70721500 @default.
• W2607044548 hasConcept C78458016 @default.
• W2607044548 hasConcept C86803240 @default.
• W2607044548 hasConceptScore W2607044548C104317684 @default.
• W2607044548 hasConceptScore W2607044548C111472728 @default.
• W2607044548 hasConceptScore W2607044548C127716648 @default.
• W2607044548 hasConceptScore W2607044548C138885662 @default.
• W2607044548 hasConceptScore W2607044548C142853389 @default.
• W2607044548 hasConceptScore W2607044548C151730666 @default.
• W2607044548 hasConceptScore W2607044548C162324750 @default.
• W2607044548 hasConceptScore W2607044548C2775905019 @default.
• W2607044548 hasConceptScore W2607044548C2779343474 @default.
• W2607044548 hasConceptScore W2607044548C31170391 @default.
• W2607044548 hasConceptScore W2607044548C34447519 @default.
• W2607044548 hasConceptScore W2607044548C41008148 @default.
• W2607044548 hasConceptScore W2607044548C54355233 @default.
• W2607044548 hasConceptScore W2607044548C61727976 @default.
• W2607044548 hasConceptScore W2607044548C70721500 @default.
• W2607044548 hasConceptScore W2607044548C78458016 @default.

• next