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- W2607090829 abstract "The design and synthesis of water soluble, amino-acid-functionalised naphthalenediimides (NDIs) as potential ligands of native G-quadruplexes is reported. The NDIs were tested on a panel of oncogene promoters, on the human telomeric sequence h-telo, and on double-stranded DNA. Out of the ligands tested, NDI 3 (Nϵ -Boc-l-lysine NDI) exhibited a highly discriminating nature by only stabilising the oncogene promoter c-kit2, which is up-regulated up to 80 % in ovarian, gastrointestinal, and breast malignancies." @default.
- W2607090829 created "2017-04-28" @default.
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- W2607090829 date "2017-05-24" @default.
- W2607090829 modified "2023-10-18" @default.
- W2607090829 title "Amino-Acid-Derived Naphthalenediimides as Versatile G-Quadruplex Binders" @default.
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- W2607090829 doi "https://doi.org/10.1002/chem.201700957" @default.
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