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• W2607096566 endingPage "539" @default.
• W2607096566 startingPage "513" @default.
• W2607096566 abstract "The increasing need for bone grafting materials, as well as the increasing incidence of bone cancer has led to an increasing interest of researchers and clinicians in developing new materials and strategies for bone tissue reconstruction and repair, as well as for the treatment of different specific diseases of the bone tissue: cancer, infections, osteoporosis, and so forth. At this moment, the most intense activity is focused in developing ceramic and composite materials for bone tissue engineering even if the use of metals is still required for the engineering of the long bones. When using metals, the main improvements are obtained by modifying their surface with adequate, active layers/coatings. The use of ceramic-polymer composite materials seems to be the most adequate alternatives. Collagen and hydroxyapatite, being the main components of the bone, are expected to be the most adequate materials for developing composite materials or bone tissue engineering, but many other materials, natural or derived from natural materials (chitosan, chitin, cellulose and especially biocellulose, alginate, etc.), as well as synthetic materials [poly-l-lactic acid, carbon-based materials, calcium phosphates (CaPs), bioglasses, etc.] can be used. Depending on the disease causing the bone defects, along with the aforementioned biomaterials, other components can be added: various nanoparticles (magnetite, silver, or gold nanoparticles, zinc or titanium oxides, etc.), active agents, such as antibiotics, cytostatics, analgesics, and so forth, and targeting agents used in cancer treatment. The present work was intended to gather some information about the role of nanotechnology in developing materials for hard tissue engineering with a special emphasis on bone cancer therapy. Based on the recent advances in the field of materials, the most promising materials for bone tissue regeneration seem to be the tissue-engineered nanocomposites, which can be designed for achieve specific functionalities." @default.
• W2607096566 created "2017-04-28" @default.
• W2607096566 creator A5027685617 @default.
• W2607096566 creator A5069350032 @default.
• W2607096566 creator A5074008413 @default.
• W2607096566 creator A5079490208 @default.
• W2607096566 date "2017-01-01" @default.
• W2607096566 modified "2023-10-16" @default.
• W2607096566 title "Nanotechnology: a challenge in hard tissue engineering with emphasis on bone cancer therapy" @default.
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