Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607096874> ?p ?o ?g. }
- W2607096874 abstract "Abstract In embryonic development, cells must differentiate through stereotypical sequences of intermediate states to generate mature states of a particular fate. By contrast, direct programming can generate similar fates through alternative routes, by directly expressing terminal transcription factors. Yet the cell state transitions defining these new routes are unclear. We applied single-cell RNA sequencing to compare two mouse motor neuron differentiation protocols: a standard protocol approximating the embryonic lineage, and a direct programming method. Both undergo similar early neural commitment. Then, rather than transitioning through spinal intermediates like the standard protocol, the direct programming path diverges into a novel transitional state. This state has specific and abnormal gene expression. It opens a ‘loop’ or ‘worm hole’ in gene expression that converges separately onto the final motor neuron state of the standard path. Despite their different developmental histories, motor neurons from both protocols structurally, functionally, and transcriptionally resemble motor neurons from embryos." @default.
- W2607096874 created "2017-04-28" @default.
- W2607096874 creator A5011044465 @default.
- W2607096874 creator A5015176214 @default.
- W2607096874 creator A5015828577 @default.
- W2607096874 creator A5016715252 @default.
- W2607096874 creator A5017534594 @default.
- W2607096874 creator A5064938000 @default.
- W2607096874 date "2017-04-05" @default.
- W2607096874 modified "2023-09-23" @default.
- W2607096874 title "Mouse embryonic stem cells can differentiate via multiple paths to the same state" @default.
- W2607096874 cites W1969764899 @default.
- W2607096874 cites W1970581324 @default.
- W2607096874 cites W1982729887 @default.
- W2607096874 cites W1982882278 @default.
- W2607096874 cites W1984883254 @default.
- W2607096874 cites W1992681202 @default.
- W2607096874 cites W1993287310 @default.
- W2607096874 cites W2021823732 @default.
- W2607096874 cites W2022507430 @default.
- W2607096874 cites W2029991507 @default.
- W2607096874 cites W2058553784 @default.
- W2607096874 cites W2060300932 @default.
- W2607096874 cites W2068881679 @default.
- W2607096874 cites W2074498796 @default.
- W2607096874 cites W2075187155 @default.
- W2607096874 cites W2081235375 @default.
- W2607096874 cites W2106483894 @default.
- W2607096874 cites W2126493828 @default.
- W2607096874 cites W2132489991 @default.
- W2607096874 cites W2133039575 @default.
- W2607096874 cites W2133437679 @default.
- W2607096874 cites W2135107819 @default.
- W2607096874 cites W2135937351 @default.
- W2607096874 cites W2136541538 @default.
- W2607096874 cites W2141545875 @default.
- W2607096874 cites W2156688270 @default.
- W2607096874 cites W2166791809 @default.
- W2607096874 cites W2167202160 @default.
- W2607096874 cites W2168221215 @default.
- W2607096874 cites W2344887288 @default.
- W2607096874 cites W2416402039 @default.
- W2607096874 cites W2465316128 @default.
- W2607096874 cites W2560354931 @default.
- W2607096874 cites W2560518516 @default.
- W2607096874 cites W4232322096 @default.
- W2607096874 doi "https://doi.org/10.1101/124594" @default.
- W2607096874 hasPublicationYear "2017" @default.
- W2607096874 type Work @default.
- W2607096874 sameAs 2607096874 @default.
- W2607096874 citedByCount "0" @default.
- W2607096874 crossrefType "posted-content" @default.
- W2607096874 hasAuthorship W2607096874A5011044465 @default.
- W2607096874 hasAuthorship W2607096874A5015176214 @default.
- W2607096874 hasAuthorship W2607096874A5015828577 @default.
- W2607096874 hasAuthorship W2607096874A5016715252 @default.
- W2607096874 hasAuthorship W2607096874A5017534594 @default.
- W2607096874 hasAuthorship W2607096874A5064938000 @default.
- W2607096874 hasBestOaLocation W26070968741 @default.
- W2607096874 hasConcept C104317684 @default.
- W2607096874 hasConcept C11413529 @default.
- W2607096874 hasConcept C142724271 @default.
- W2607096874 hasConcept C145103041 @default.
- W2607096874 hasConcept C148738053 @default.
- W2607096874 hasConcept C169760540 @default.
- W2607096874 hasConcept C204787440 @default.
- W2607096874 hasConcept C2776752467 @default.
- W2607096874 hasConcept C2776817793 @default.
- W2607096874 hasConcept C2777620950 @default.
- W2607096874 hasConcept C2780385302 @default.
- W2607096874 hasConcept C2780775167 @default.
- W2607096874 hasConcept C28328180 @default.
- W2607096874 hasConcept C41008148 @default.
- W2607096874 hasConcept C48103436 @default.
- W2607096874 hasConcept C54355233 @default.
- W2607096874 hasConcept C70721500 @default.
- W2607096874 hasConcept C71924100 @default.
- W2607096874 hasConcept C86803240 @default.
- W2607096874 hasConcept C95444343 @default.
- W2607096874 hasConceptScore W2607096874C104317684 @default.
- W2607096874 hasConceptScore W2607096874C11413529 @default.
- W2607096874 hasConceptScore W2607096874C142724271 @default.
- W2607096874 hasConceptScore W2607096874C145103041 @default.
- W2607096874 hasConceptScore W2607096874C148738053 @default.
- W2607096874 hasConceptScore W2607096874C169760540 @default.
- W2607096874 hasConceptScore W2607096874C204787440 @default.
- W2607096874 hasConceptScore W2607096874C2776752467 @default.
- W2607096874 hasConceptScore W2607096874C2776817793 @default.
- W2607096874 hasConceptScore W2607096874C2777620950 @default.
- W2607096874 hasConceptScore W2607096874C2780385302 @default.
- W2607096874 hasConceptScore W2607096874C2780775167 @default.
- W2607096874 hasConceptScore W2607096874C28328180 @default.
- W2607096874 hasConceptScore W2607096874C41008148 @default.
- W2607096874 hasConceptScore W2607096874C48103436 @default.
- W2607096874 hasConceptScore W2607096874C54355233 @default.
- W2607096874 hasConceptScore W2607096874C70721500 @default.
- W2607096874 hasConceptScore W2607096874C71924100 @default.
- W2607096874 hasConceptScore W2607096874C86803240 @default.
- W2607096874 hasConceptScore W2607096874C95444343 @default.
- W2607096874 hasLocation W26070968741 @default.