FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607125758> ?p ?o ?g. }

• W2607125758 endingPage "1401" @default.
• W2607125758 startingPage "1392" @default.
• W2607125758 abstract "Alcoholic cardiomyopathy (ACM) can develop after consumption of relatively large amounts of alcohol over time or from acute binge drinking. Of the many factors implicated in the etiology of ACM, chronic perturbation in protein balance has been strongly implicated. This review focused on recent contributions (since 2010) in the area of protein metabolism and cardiac function related to ACM. Data reviewed include that from in vitro and preclinical in vivo animal studies where alcohol or an oxidative metabolite was studied and outcome measures in either cardiomyocytes or whole heart pertaining to protein synthesis or degradation were reported. Additionally, studies on the contractile properties of cardiomyocytes were also included to link signal transduction with function. Methodological differences including the potential impact of sex, dosing, and duration/timing of alcohol administration are addressed. Acute and chronic alcohol consumption decreases cardiac protein synthesis and/or activation of proteins within the regulatory mammalian/mechanistic target of rapamycin complex pathway. Albeit limited, evidence suggests that myocardial protein degradation via the ubiquitin pathway is not altered, while autophagy may be enhanced in ACM. Alcohol impairs ex vivo cardiomyocyte contractility in relation to its metabolism and expression of proteins within the growth factor pathway. Dysregulation of protein metabolism, including the rate of protein synthesis and autophagy, may contribute to contractile deficits and is a hallmark feature of ACM meriting additional sex-inclusive, methodologically consistent studies." @default.
• W2607125758 created "2017-04-28" @default.
• W2607125758 creator A5023535556 @default.
• W2607125758 creator A5073807348 @default.
• W2607125758 date "2017-05-29" @default.
• W2607125758 modified "2023-10-17" @default.
• W2607125758 title "Alcoholic Cardiomyopathy: Disrupted Protein Balance and Impaired Cardiomyocyte Contractility" @default.
• W2607125758 cites W1523693806 @default.
• W2607125758 cites W1643583893 @default.
• W2607125758 cites W189026355 @default.
• W2607125758 cites W1893438761 @default.
• W2607125758 cites W1946561826 @default.
• W2607125758 cites W1966953477 @default.
• W2607125758 cites W1970637701 @default.
• W2607125758 cites W1973310114 @default.
• W2607125758 cites W1977904428 @default.
• W2607125758 cites W1980072383 @default.
• W2607125758 cites W1987036240 @default.
• W2607125758 cites W1995395637 @default.
• W2607125758 cites W1995627027 @default.
• W2607125758 cites W2001591494 @default.
• W2607125758 cites W2005598030 @default.
• W2607125758 cites W2010512217 @default.
• W2607125758 cites W2011282245 @default.
• W2607125758 cites W2011549346 @default.
• W2607125758 cites W2016582431 @default.
• W2607125758 cites W2022721973 @default.
• W2607125758 cites W2030343130 @default.
• W2607125758 cites W2036689746 @default.
• W2607125758 cites W2036903182 @default.
• W2607125758 cites W2049075297 @default.
• W2607125758 cites W2049918843 @default.
• W2607125758 cites W2054324516 @default.
• W2607125758 cites W2065514329 @default.
• W2607125758 cites W2072307557 @default.
• W2607125758 cites W2076937488 @default.
• W2607125758 cites W2078908674 @default.
• W2607125758 cites W2078966733 @default.
• W2607125758 cites W2083155231 @default.
• W2607125758 cites W2083354984 @default.
• W2607125758 cites W2087206099 @default.
• W2607125758 cites W2092833061 @default.
• W2607125758 cites W2093713104 @default.
• W2607125758 cites W2094114098 @default.
• W2607125758 cites W2110263487 @default.
• W2607125758 cites W2115147488 @default.
• W2607125758 cites W2116632678 @default.
• W2607125758 cites W2125040575 @default.
• W2607125758 cites W2126609164 @default.
• W2607125758 cites W2129431489 @default.
• W2607125758 cites W2130396048 @default.
• W2607125758 cites W2131175598 @default.
• W2607125758 cites W2132867590 @default.
• W2607125758 cites W2145247531 @default.
• W2607125758 cites W2150391242 @default.
• W2607125758 cites W2157900120 @default.
• W2607125758 cites W2159985122 @default.
• W2607125758 cites W2162079638 @default.
• W2607125758 cites W2165366647 @default.
• W2607125758 cites W2171657155 @default.
• W2607125758 cites W2172765268 @default.
• W2607125758 cites W2183111661 @default.
• W2607125758 cites W2299864672 @default.
• W2607125758 cites W2340126464 @default.
• W2607125758 cites W2342225754 @default.
• W2607125758 cites W2393920708 @default.
• W2607125758 cites W2399615356 @default.
• W2607125758 doi "https://doi.org/10.1111/acer.13405" @default.
• W2607125758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5522635" @default.
• W2607125758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28425109" @default.
• W2607125758 hasPublicationYear "2017" @default.
• W2607125758 type Work @default.
• W2607125758 sameAs 2607125758 @default.
• W2607125758 citedByCount "17" @default.
• W2607125758 countsByYear W26071257582018 @default.
• W2607125758 countsByYear W26071257582019 @default.
• W2607125758 countsByYear W26071257582020 @default.
• W2607125758 countsByYear W26071257582021 @default.
• W2607125758 countsByYear W26071257582022 @default.
• W2607125758 countsByYear W26071257582023 @default.
• W2607125758 crossrefType "journal-article" @default.
• W2607125758 hasAuthorship W2607125758A5023535556 @default.
• W2607125758 hasAuthorship W2607125758A5073807348 @default.
• W2607125758 hasBestOaLocation W26071257582 @default.
• W2607125758 hasConcept C126322002 @default.
• W2607125758 hasConcept C134018914 @default.
• W2607125758 hasConcept C190283241 @default.
• W2607125758 hasConcept C203522944 @default.
• W2607125758 hasConcept C207001950 @default.
• W2607125758 hasConcept C2777873954 @default.
• W2607125758 hasConcept C2778198053 @default.
• W2607125758 hasConcept C2778797674 @default.
• W2607125758 hasConcept C2992195973 @default.
• W2607125758 hasConcept C39133596 @default.
• W2607125758 hasConcept C54355233 @default.
• W2607125758 hasConcept C55493867 @default.
• W2607125758 hasConcept C71924100 @default.
• W2607125758 hasConcept C86803240 @default.

• next