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• W2607147921 abstract "Increased expression of microRNA-500a (miR-500a) has been reported in the serum of hepatocellular carcinoma (HCC) patients. However, the biological effects and mechanisms of miR-500a in hepatoma cells remain unclear. In this study, we found that miR-500a expression was up-regulated in HCC cell lines and tissues, and that high levels of miR-500a was associated with poor prognosis. We found that miR-500a upregulation promoted migration and invasion in two hepatoma cell lines, HCCLM3 and SMMC7721, while miR-500a downregulation had the opposite effect. We demonstrated that miR-500a activates the Wnt/β-catenin signaling pathway by directly binding to the 3′-untranslated region (UTR) of SFRP2 and GSK-3β mRNA. In conclusion, our results indicate miR-500a promotes HCC migration and invasion through activating Wnt/β-catenin signaling by directly binding to SFPR2 and GSK-3β." @default.
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• W2607147921 date "2017-07-01" @default.
• W2607147921 modified "2023-10-15" @default.
• W2607147921 title "MicroRNA-500a promotes migration and invasion in hepatocellular carcinoma by activating the Wnt/β-catenin signaling pathway" @default.
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• W2607147921 doi "https://doi.org/10.1016/j.biopha.2017.04.018" @default.
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