Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607156962> ?p ?o ?g. }
- W2607156962 endingPage "17.2017" @default.
- W2607156962 startingPage "ENEURO.0073" @default.
- W2607156962 abstract "Most vertebrates show concussion responses when their heads are hit suddenly by heavy objects. Previous studies have focused on the direct physical injuries to the neural tissue caused by the concussive blow. We study a similar behavior in a simple vertebrate, the Xenopus laevis tadpole. We find that concussion-like behavior can be reliably induced by the mechanosensory stimulation of the head skin without direct physical impacts on the brain. Head skin stimulation activates a cholinergic pathway which then opens G protein-coupled inward-rectifying potassium channels (GIRKs) via postsynaptic M 2 muscarinic receptors to inhibit brainstem neurons critical for the initiation and maintenance of swimming for up to minutes and can explain many features commonly observed immediately after concussion. We propose that some acute symptoms of concussion in vertebrates can be explained by the opening of GIRKs following mechanosensory stimulation to the head." @default.
- W2607156962 created "2017-04-28" @default.
- W2607156962 creator A5001638119 @default.
- W2607156962 creator A5035106083 @default.
- W2607156962 creator A5070480426 @default.
- W2607156962 date "2017-03-01" @default.
- W2607156962 modified "2023-10-14" @default.
- W2607156962 title "Mechanosensory Stimulation Evokes Acute Concussion-Like Behavior by Activating GIRKs Coupled to Muscarinic Receptors in a Simple Vertebrate" @default.
- W2607156962 cites W1423885769 @default.
- W2607156962 cites W1564229154 @default.
- W2607156962 cites W1574030158 @default.
- W2607156962 cites W1588811476 @default.
- W2607156962 cites W1753480680 @default.
- W2607156962 cites W1919308600 @default.
- W2607156962 cites W1937404454 @default.
- W2607156962 cites W1953088445 @default.
- W2607156962 cites W1958218347 @default.
- W2607156962 cites W1964222129 @default.
- W2607156962 cites W1971345721 @default.
- W2607156962 cites W1973937621 @default.
- W2607156962 cites W1975836557 @default.
- W2607156962 cites W1981562838 @default.
- W2607156962 cites W1982168518 @default.
- W2607156962 cites W1982859542 @default.
- W2607156962 cites W1986436832 @default.
- W2607156962 cites W1987014245 @default.
- W2607156962 cites W1987512190 @default.
- W2607156962 cites W1989428010 @default.
- W2607156962 cites W1990564140 @default.
- W2607156962 cites W1991157007 @default.
- W2607156962 cites W1992166336 @default.
- W2607156962 cites W1992318639 @default.
- W2607156962 cites W1992669875 @default.
- W2607156962 cites W1997390136 @default.
- W2607156962 cites W2000732994 @default.
- W2607156962 cites W2006049614 @default.
- W2607156962 cites W2007839335 @default.
- W2607156962 cites W2013672355 @default.
- W2607156962 cites W2013805868 @default.
- W2607156962 cites W2016951447 @default.
- W2607156962 cites W2021633512 @default.
- W2607156962 cites W2033828938 @default.
- W2607156962 cites W2035034148 @default.
- W2607156962 cites W2036409098 @default.
- W2607156962 cites W2041204070 @default.
- W2607156962 cites W2046591453 @default.
- W2607156962 cites W2048137511 @default.
- W2607156962 cites W2049300139 @default.
- W2607156962 cites W2049775909 @default.
- W2607156962 cites W2051682093 @default.
- W2607156962 cites W2052123644 @default.
- W2607156962 cites W2055904512 @default.
- W2607156962 cites W2056781731 @default.
- W2607156962 cites W2057462857 @default.
- W2607156962 cites W2075559849 @default.
- W2607156962 cites W2080329113 @default.
- W2607156962 cites W2080648247 @default.
- W2607156962 cites W2080805171 @default.
- W2607156962 cites W2088889090 @default.
- W2607156962 cites W2088992068 @default.
- W2607156962 cites W2090809005 @default.
- W2607156962 cites W2090848123 @default.
- W2607156962 cites W2097694278 @default.
- W2607156962 cites W2097694848 @default.
- W2607156962 cites W2106333818 @default.
- W2607156962 cites W2109646972 @default.
- W2607156962 cites W2109716894 @default.
- W2607156962 cites W2111683315 @default.
- W2607156962 cites W2114959559 @default.
- W2607156962 cites W2126798713 @default.
- W2607156962 cites W2127358013 @default.
- W2607156962 cites W2129701484 @default.
- W2607156962 cites W2133052215 @default.
- W2607156962 cites W2135781323 @default.
- W2607156962 cites W2135846057 @default.
- W2607156962 cites W2138098510 @default.
- W2607156962 cites W2142416032 @default.
- W2607156962 cites W2144797544 @default.
- W2607156962 cites W2148855618 @default.
- W2607156962 cites W2149175115 @default.
- W2607156962 cites W2160648569 @default.
- W2607156962 cites W2166867937 @default.
- W2607156962 cites W2172788585 @default.
- W2607156962 cites W2176428774 @default.
- W2607156962 cites W2179369946 @default.
- W2607156962 cites W2230530498 @default.
- W2607156962 cites W2318013326 @default.
- W2607156962 cites W2334800624 @default.
- W2607156962 cites W2404971042 @default.
- W2607156962 cites W2416871142 @default.
- W2607156962 cites W4234599967 @default.
- W2607156962 cites W4249537333 @default.
- W2607156962 doi "https://doi.org/10.1523/eneuro.0073-17.2017" @default.
- W2607156962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5409982" @default.
- W2607156962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28462392" @default.
- W2607156962 hasPublicationYear "2017" @default.
- W2607156962 type Work @default.
- W2607156962 sameAs 2607156962 @default.