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• W2607165718 abstract "Abstract Mast cells (MCs) play pivotal roles in allergic reactions and the host defense against microbial infection through the IgE-dependent and IgE-independent signaling pathways. MC lines that can be analyzed both in vitro and in vivo would be useful for the study of MC-dependent immune responses. Here, we investigated the functional characteristics of a mouse embryonic stem cell-derived MC-like cell line, MEDMC-BRC6. The cell line expressed FcεRI and c-Kit and showed degranulation and production of inflammatory cytokines and chemokines, including TNF-α, IL-6 and MCP-1, upon cross-linking FcεRI with IgE. These cytokines and chemokines were also produced by the cell line by stimulation of TLR2 and TLR4. MEDMC-BRC6 survived in the peritoneal cavity and the ear skin for at least 6 months after the transfer into genetically compatible MC-deficient KitW-sh/W-sh mice, in which systemic anaphylaxis was successfully induced. Thus, MEDMC-BRC6 cells represent a potent tool for investigating the functions of MCs in vitro and in vivo." @default.
• W2607165718 created "2017-04-28" @default.
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• W2607165718 date "2017-04-18" @default.
• W2607165718 modified "2023-10-13" @default.
• W2607165718 title "Long-term survival of the mouse ES cell-derived mast cell, MEDMC-BRC6, in mast cell-deficient <i>Kit</i> <i>W-sh/W-sh</i> mice" @default.
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• W2607165718 doi "https://doi.org/10.1093/intimm/dxx022" @default.
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