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• W2607172144 abstract "Here, we report on a strategy to encapsulate cancer cell lysate in immunomodulating microparticles in view of their potential use in personalized anticancer vaccination. In a first step, cancer cell lysate is entrapped into porous calcium carbonate (CaCO3) microparticles by a coprecipitation reaction. Second, a polymer substituted with a small molecule TLR7/8-agonist is adorbed onto the surface of the microparticles. Relative to soluble cell lysate, microparticle encapsulation yielded higher uptake of cell lysate by dendritic cells in vitro. Also, microparticle-adsorbed polymeric TLR7/8-agonists retained their TLR-triggering capacity resulting in immunogenic vaccine particles. We anticipate this strategy might hold potential to turn patient-derived tumor tissue, comprising the patient’s own mutanome, into potent personalized anticancer vaccines." @default.
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• W2607172144 date "2017-05-03" @default.
• W2607172144 modified "2023-10-02" @default.
• W2607172144 title "Cancer Cell Lysate Entrapment in CaCO₃ Engineered with Polymeric TLR-Agonists: Immune-Modulating Microparticles in View of Personalized Antitumor Vaccination" @default.
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• W2607172144 doi "https://doi.org/10.1021/acs.chemmater.6b05062" @default.
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