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• W2607173627 abstract "Cisplatin is a widely used anticancer drug, while non-targeted delivery, development of drug resistance, and serious side effects significantly limit its clinical use. In order to improve the tumor-targeting properties of cisplatin, transferrin (Tf) was employed as a carrier to transfer cisplatin into cancer cells via transferrin receptor 1 (TfR1) mediated endocytosis. The binding ability of cisplatin and Tf could be improved by pretreating Tf with 10% ethanol, and the binding number of cisplatin for each Tf molecule could reach to 40 without structural or functional impairment of Tf. The Tf-cisplatin complex could be delivered into human ovarian carcinoma cells high efficiently. In tumor-bearing nude-mice model, the Tf-cisplatin complex inhibited tumor growth in vivo more effectively than free cisplatin, with less toxicity in other tissues. Tumor targeting efficiency of the Tf-cisplatin complex was supported by in vivo and ex vivo imaging and platinum residues detected in each ex vivo organ. These data suggested that Tf-cisplatin was more effective and less drug-resistance than cisplatin, with targeting to tumor cells. Therefore, Tf-mediated delivery of cisplatin is a potential strategy for targeted delivery into tumor cells." @default.
• W2607173627 created "2017-04-28" @default.
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• W2607173627 date "2017-04-21" @default.
• W2607173627 modified "2023-10-14" @default.
• W2607173627 title "Enhanced antitumor efficacy of cisplatin for treating ovarian cancer <i>in vitro</i> and <i>in vivo</i> via transferrin binding" @default.
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• W2607173627 doi "https://doi.org/10.18632/oncotarget.17316" @default.
• W2607173627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5542211" @default.
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