FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607199615> ?p ?o ?g. }

• W2607199615 endingPage "69476" @default.
• W2607199615 startingPage "69465" @default.
• W2607199615 abstract "Triterpenoids from the Aglaia have been shown cytotoxicity on a broad spectrum of human tumor cells. In the present study, we extracted triterpenoids AA-5 (1) and AA-6 (2) from stems of Aglaia abbreviata, and studied their cytotoxicity in multidrug resistant (MDR) MCF-7/ADM cells. After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. The drug efflux transporter P-glycoprotein (P-gp) and the intracellular antioxidant systems, involving Glutathione S-Transferase π, Glutathione and heme oxygenase-1, were also inhibited via the ROS-depressed Akt/NF-E2-related factor 2 pathway. Furthermore, 2 h-treatment of AA-6 (2) at non-toxic concentrations exhibited MDR reversal effects with no alteration on P-gp expression but increased drug accumulation ability. AA-6 alos demonstrated synergetic effects with classic anti-tumor agents. Moreover, computational modeling studies showed that AA-6 (2) might bind to the modulator site on P-gp and act as an inhibitor, not a substrate of P-gp. Therefore, AA-5 (1) and AA-6 (2) may be effective anti-tumor and reversal agents for the further development of therapeutics against MDR breast cancer." @default.
• W2607199615 created "2017-04-28" @default.
• W2607199615 creator A5021027192 @default.
• W2607199615 creator A5035668925 @default.
• W2607199615 creator A5046221315 @default.
• W2607199615 creator A5058524515 @default.
• W2607199615 creator A5066716873 @default.
• W2607199615 creator A5076956379 @default.
• W2607199615 date "2017-04-20" @default.
• W2607199615 modified "2023-09-28" @default.
• W2607199615 title "Triterpenoids from<i>Aglaia abbreviata</i>exert cytotoxicity and multidrug resistant reversal effect in MCF-7/ADM cells via reactive oxygen species induction and P-glycoprotein inhibition" @default.
• W2607199615 cites W1487283858 @default.
• W2607199615 cites W1519177607 @default.
• W2607199615 cites W1967108243 @default.
• W2607199615 cites W1977544523 @default.
• W2607199615 cites W1984009434 @default.
• W2607199615 cites W1989310657 @default.
• W2607199615 cites W1989335851 @default.
• W2607199615 cites W1990839388 @default.
• W2607199615 cites W2003143133 @default.
• W2607199615 cites W2013995823 @default.
• W2607199615 cites W2030364165 @default.
• W2607199615 cites W2037691927 @default.
• W2607199615 cites W2050456292 @default.
• W2607199615 cites W2050468178 @default.
• W2607199615 cites W2054035757 @default.
• W2607199615 cites W2055904567 @default.
• W2607199615 cites W2057393894 @default.
• W2607199615 cites W2061260890 @default.
• W2607199615 cites W2075176601 @default.
• W2607199615 cites W2079738759 @default.
• W2607199615 cites W2087311397 @default.
• W2607199615 cites W2091093872 @default.
• W2607199615 cites W2097961562 @default.
• W2607199615 cites W2103394810 @default.
• W2607199615 cites W2103562758 @default.
• W2607199615 cites W2127247883 @default.
• W2607199615 cites W2160618318 @default.
• W2607199615 cites W2198611676 @default.
• W2607199615 cites W2222000147 @default.
• W2607199615 cites W2323196655 @default.
• W2607199615 cites W2566044733 @default.
• W2607199615 cites W2739999456 @default.
• W2607199615 cites W840875033 @default.
• W2607199615 doi "https://doi.org/10.18632/oncotarget.17287" @default.
• W2607199615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5642492" @default.
• W2607199615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29050217" @default.
• W2607199615 hasPublicationYear "2017" @default.
• W2607199615 type Work @default.
• W2607199615 sameAs 2607199615 @default.
• W2607199615 citedByCount "5" @default.
• W2607199615 countsByYear W26071996152019 @default.
• W2607199615 countsByYear W26071996152020 @default.
• W2607199615 countsByYear W26071996152021 @default.
• W2607199615 countsByYear W26071996152022 @default.
• W2607199615 crossrefType "journal-article" @default.
• W2607199615 hasAuthorship W2607199615A5021027192 @default.
• W2607199615 hasAuthorship W2607199615A5035668925 @default.
• W2607199615 hasAuthorship W2607199615A5046221315 @default.
• W2607199615 hasAuthorship W2607199615A5058524515 @default.
• W2607199615 hasAuthorship W2607199615A5066716873 @default.
• W2607199615 hasAuthorship W2607199615A5076956379 @default.
• W2607199615 hasBestOaLocation W26071996151 @default.
• W2607199615 hasConcept C109316439 @default.
• W2607199615 hasConcept C109541995 @default.
• W2607199615 hasConcept C121608353 @default.
• W2607199615 hasConcept C133936738 @default.
• W2607199615 hasConcept C181199279 @default.
• W2607199615 hasConcept C185592680 @default.
• W2607199615 hasConcept C190283241 @default.
• W2607199615 hasConcept C200082930 @default.
• W2607199615 hasConcept C202751555 @default.
• W2607199615 hasConcept C2778707650 @default.
• W2607199615 hasConcept C2994423619 @default.
• W2607199615 hasConcept C48349386 @default.
• W2607199615 hasConcept C501593827 @default.
• W2607199615 hasConcept C538909803 @default.
• W2607199615 hasConcept C54355233 @default.
• W2607199615 hasConcept C55493867 @default.
• W2607199615 hasConcept C79879829 @default.
• W2607199615 hasConcept C86803240 @default.
• W2607199615 hasConcept C96232424 @default.
• W2607199615 hasConcept C98274493 @default.
• W2607199615 hasConceptScore W2607199615C109316439 @default.
• W2607199615 hasConceptScore W2607199615C109541995 @default.
• W2607199615 hasConceptScore W2607199615C121608353 @default.
• W2607199615 hasConceptScore W2607199615C133936738 @default.
• W2607199615 hasConceptScore W2607199615C181199279 @default.
• W2607199615 hasConceptScore W2607199615C185592680 @default.
• W2607199615 hasConceptScore W2607199615C190283241 @default.
• W2607199615 hasConceptScore W2607199615C200082930 @default.
• W2607199615 hasConceptScore W2607199615C202751555 @default.
• W2607199615 hasConceptScore W2607199615C2778707650 @default.
• W2607199615 hasConceptScore W2607199615C2994423619 @default.
• W2607199615 hasConceptScore W2607199615C48349386 @default.
• W2607199615 hasConceptScore W2607199615C501593827 @default.
• W2607199615 hasConceptScore W2607199615C538909803 @default.
• W2607199615 hasConceptScore W2607199615C54355233 @default.

• next