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• W2607210007 abstract "We recently demonstrated the existence of a complex hormonal balance between steroid hormones in the control of RACK1 (Receptor for Activated C Kinase 1) expression and immune activation, suggesting that this scaffold protein may also be targeted by endocrine disrupting chemicals (EDCs). As a proof of concept, we investigated the effect of the doping agent nandrolone, an androgen receptor (AR) agonist, and of p,p'DDT (dichlorodiphenyltrichloroethane) and its main metabolite p,p'DDE (dichlorodiphenyldichloroethylene), a weak and strong AR antagonist, respectively, on RACK1 expression and innate immune response. In analogy to endogenous androgens, nandrolone induced a dose-related increase in RACK1 transcriptional activity and protein expression, resulting in increased LPS-induced IL-8 and TNF-α production and proliferation in THP-1 cells. Conversely, p,p'DDT and p,p'DDE significantly decrease RACK1 expression, LPS-induced cytokine production and CD86 expression; with p,p'DDE exerting a stronger repressor effect than p,p'DDT, consistent with its stronger AR antagonistic effect. These results indicate that RACK1 could be a relevant target of EDCs, responding in opposite ways to agonist or antagonist of AR, representing a bridge between the endocrine system and the innate immune system." @default.
• W2607210007 created "2017-04-28" @default.
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• W2607210007 date "2017-06-01" @default.
• W2607210007 modified "2023-10-01" @default.
• W2607210007 title "The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with important implication in immunity" @default.
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• W2607210007 doi "https://doi.org/10.1016/j.taap.2017.04.011" @default.
• W2607210007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28412309" @default.
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