Matches in SemOpenAlex for { <https://semopenalex.org/work/W26072223> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W26072223 endingPage "9" @default.
- W26072223 startingPage "253" @default.
- W26072223 abstract "Eosinophils participate in the pathogenesis of inflammatory diseases of the respiratory tract and the gut. We investigated the constitutive presence of eosinophils and mononuclear cells in the macroscopically normal duodenal mucosa of patients with asthma and allergic rhinitis. Macroscopically normal duodenal specimens were obtained at routine endoscopy for upper gastrointestinal symptoms from 16 patients with asthma and 13 patients with allergic rhinitis. Twelve nonatopic patients with irritable bowel syndrome were studied as controls. Specimens were analyzed by immunohistochemistry using a panel of antibodies to human eosinophil cationic protein clone EG1 (EG1) and clone EG2 (EG2), anti-human interleukin (anti-hIL)-5, anti-hIL-4, anti-CD4, and anti-CD68. Significantly increased numbers of eosinophils stained with EG1 and EG2 were found in the duodenum of patients with asthma and allergic rhinitis compared with controls. IL-5+ cells and IL-4+ cells were detected in significantly increased numbers in the duodenal mucosa of patients with asthma and rhinitis compared with controls. Mononuclear cells expressing CD4 (helper T cells) and CD68 (macrophages) also were significantly increased in the duodenal mucosa of asthma and rhinitis compared with controls. Accumulation of eosinophils in conjunction with IL-4+ cells and IL-5+ cells in the noninflamed duodenal mucosa may reflect a predominant T helper cell subset 2 systemic immune response in patients with asthma and allergic rhinitis. The absence of intestinal inflammation despite the marked presence of cells implicated in the allergic inflammation suggests that local mechanisms might determine the state of nonresponsiveness in the gut mucosa of patients with asthma and allergic rhinitis." @default.
- W26072223 created "2016-06-24" @default.
- W26072223 creator A5002139362 @default.
- W26072223 creator A5019584865 @default.
- W26072223 creator A5044552093 @default.
- W26072223 creator A5045045063 @default.
- W26072223 creator A5045507059 @default.
- W26072223 creator A5072983872 @default.
- W26072223 creator A5073599143 @default.
- W26072223 creator A5075789614 @default.
- W26072223 date "2004-10-30" @default.
- W26072223 modified "2023-09-27" @default.
- W26072223 title "Small bowel of patients with asthma and allergic rhinitis: absence of inflammation despite the presence of major cellular components of allergic inflammation." @default.
- W26072223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15510586" @default.
- W26072223 hasPublicationYear "2004" @default.
- W26072223 type Work @default.
- W26072223 sameAs 26072223 @default.
- W26072223 citedByCount "9" @default.
- W26072223 countsByYear W260722232012 @default.
- W26072223 countsByYear W260722232014 @default.
- W26072223 countsByYear W260722232015 @default.
- W26072223 countsByYear W260722232016 @default.
- W26072223 countsByYear W260722232018 @default.
- W26072223 countsByYear W260722232022 @default.
- W26072223 crossrefType "journal-article" @default.
- W26072223 hasAuthorship W26072223A5002139362 @default.
- W26072223 hasAuthorship W26072223A5019584865 @default.
- W26072223 hasAuthorship W26072223A5044552093 @default.
- W26072223 hasAuthorship W26072223A5045045063 @default.
- W26072223 hasAuthorship W26072223A5045507059 @default.
- W26072223 hasAuthorship W26072223A5072983872 @default.
- W26072223 hasAuthorship W26072223A5073599143 @default.
- W26072223 hasAuthorship W26072223A5075789614 @default.
- W26072223 hasConcept C126322002 @default.
- W26072223 hasConcept C203014093 @default.
- W26072223 hasConcept C204232928 @default.
- W26072223 hasConcept C207480886 @default.
- W26072223 hasConcept C2776042228 @default.
- W26072223 hasConcept C2776460901 @default.
- W26072223 hasConcept C2776914184 @default.
- W26072223 hasConcept C2777037409 @default.
- W26072223 hasConcept C2778271842 @default.
- W26072223 hasConcept C2779675166 @default.
- W26072223 hasConcept C2780942790 @default.
- W26072223 hasConcept C71924100 @default.
- W26072223 hasConcept C88675164 @default.
- W26072223 hasConceptScore W26072223C126322002 @default.
- W26072223 hasConceptScore W26072223C203014093 @default.
- W26072223 hasConceptScore W26072223C204232928 @default.
- W26072223 hasConceptScore W26072223C207480886 @default.
- W26072223 hasConceptScore W26072223C2776042228 @default.
- W26072223 hasConceptScore W26072223C2776460901 @default.
- W26072223 hasConceptScore W26072223C2776914184 @default.
- W26072223 hasConceptScore W26072223C2777037409 @default.
- W26072223 hasConceptScore W26072223C2778271842 @default.
- W26072223 hasConceptScore W26072223C2779675166 @default.
- W26072223 hasConceptScore W26072223C2780942790 @default.
- W26072223 hasConceptScore W26072223C71924100 @default.
- W26072223 hasConceptScore W26072223C88675164 @default.
- W26072223 hasIssue "4" @default.
- W26072223 hasLocation W260722231 @default.
- W26072223 hasOpenAccess W26072223 @default.
- W26072223 hasPrimaryLocation W260722231 @default.
- W26072223 hasRelatedWork W1966575505 @default.
- W26072223 hasRelatedWork W1966744313 @default.
- W26072223 hasRelatedWork W1972041335 @default.
- W26072223 hasRelatedWork W1975587146 @default.
- W26072223 hasRelatedWork W1976068711 @default.
- W26072223 hasRelatedWork W1977005065 @default.
- W26072223 hasRelatedWork W1995215780 @default.
- W26072223 hasRelatedWork W200232069 @default.
- W26072223 hasRelatedWork W2048544637 @default.
- W26072223 hasRelatedWork W2052140619 @default.
- W26072223 hasRelatedWork W2071514471 @default.
- W26072223 hasRelatedWork W2089290834 @default.
- W26072223 hasRelatedWork W2100143585 @default.
- W26072223 hasRelatedWork W2108482413 @default.
- W26072223 hasRelatedWork W2121002052 @default.
- W26072223 hasRelatedWork W2140216982 @default.
- W26072223 hasRelatedWork W2144622934 @default.
- W26072223 hasRelatedWork W2152965196 @default.
- W26072223 hasRelatedWork W2312813422 @default.
- W26072223 hasRelatedWork W2593538935 @default.
- W26072223 hasVolume "25" @default.
- W26072223 isParatext "false" @default.
- W26072223 isRetracted "false" @default.
- W26072223 magId "26072223" @default.
- W26072223 workType "article" @default.