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- W2607238518 endingPage "954" @default.
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- W2607238518 abstract "Serotonin (5-HT) is an important neurotransmitter in the central nervous system where it modulates circuits involved in mood, cognition, movement, arousal, and autonomic function. The 5-HT transporter (SERT; SLC6A4) is a key regulator of 5-HT signaling, and genetic variations in SERT are associated with various disorders including depression, anxiety, and autism. This review focuses on the role of SERT in the sympathetic nervous system. Autonomic/sympathetic dysfunction is evident in patients with depression, anxiety, and other diseases linked to serotonergic signaling. Experimentally, loss of SERT function (SERT knockout mice or chronic pharmacological block) has been reported to augment the sympathetic stress response. Alterations to serotonergic signaling in the CNS and thus central drive to the peripheral sympathetic nervous system are presumed to underlie this augmentation. Although less widely recognized, SERT is robustly expressed in chromaffin cells of the adrenal medulla, the neuroendocrine arm of the sympathetic nervous system. Adrenal chromaffin cells do not synthesize 5-HT but accumulate small amounts by SERT-mediated uptake. Recent evidence demonstrated that 5-HT1A receptors inhibit catecholamine secretion from adrenal chromaffin cells via an atypical mechanism that does not involve modulation of cellular excitability or voltage-gated Ca2+ channels. This raises the possibility that the adrenal medulla is a previously unrecognized peripheral hub for serotonergic control of the sympathetic stress response. As a framework for future investigation, a model is proposed in which stress-evoked adrenal catecholamine secretion is fine-tuned by SERT-modulated autocrine 5-HT signaling." @default.
- W2607238518 created "2017-04-28" @default.
- W2607238518 creator A5022425643 @default.
- W2607238518 creator A5022624885 @default.
- W2607238518 creator A5023759527 @default.
- W2607238518 creator A5056560427 @default.
- W2607238518 date "2017-04-13" @default.
- W2607238518 modified "2023-10-11" @default.
- W2607238518 title "Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response" @default.
- W2607238518 cites W1479680617 @default.
- W2607238518 cites W1484670943 @default.
- W2607238518 cites W1509155252 @default.
- W2607238518 cites W1538879480 @default.
- W2607238518 cites W1561757844 @default.
- W2607238518 cites W1584902624 @default.
- W2607238518 cites W159617335 @default.
- W2607238518 cites W1599906730 @default.
- W2607238518 cites W1599934497 @default.
- W2607238518 cites W162944462 @default.
- W2607238518 cites W1654673127 @default.
- W2607238518 cites W1673114315 @default.
- W2607238518 cites W178602103 @default.
- W2607238518 cites W1826950194 @default.
- W2607238518 cites W1916112395 @default.
- W2607238518 cites W1929691281 @default.
- W2607238518 cites W1964583098 @default.
- W2607238518 cites W1965846839 @default.
- W2607238518 cites W1967842669 @default.
- W2607238518 cites W1967987557 @default.
- W2607238518 cites W1968415875 @default.
- W2607238518 cites W1971754586 @default.
- W2607238518 cites W1972211504 @default.
- W2607238518 cites W1975427773 @default.
- W2607238518 cites W1978465685 @default.
- W2607238518 cites W1979306029 @default.
- W2607238518 cites W1980478847 @default.
- W2607238518 cites W1981471126 @default.
- W2607238518 cites W1983584483 @default.
- W2607238518 cites W1985169379 @default.
- W2607238518 cites W1986873747 @default.
- W2607238518 cites W1989436490 @default.
- W2607238518 cites W1990787076 @default.
- W2607238518 cites W1991273592 @default.
- W2607238518 cites W1993313807 @default.
- W2607238518 cites W1993359476 @default.
- W2607238518 cites W1994514599 @default.
- W2607238518 cites W1996818913 @default.
- W2607238518 cites W1997088845 @default.
- W2607238518 cites W1998807018 @default.
- W2607238518 cites W1999238614 @default.
- W2607238518 cites W2000380515 @default.
- W2607238518 cites W2000789056 @default.
- W2607238518 cites W2001479580 @default.
- W2607238518 cites W2001909401 @default.
- W2607238518 cites W2003049002 @default.
- W2607238518 cites W2007077740 @default.
- W2607238518 cites W2007716489 @default.
- W2607238518 cites W2008119750 @default.
- W2607238518 cites W2008375853 @default.
- W2607238518 cites W2008626322 @default.
- W2607238518 cites W2009852374 @default.
- W2607238518 cites W2011202256 @default.
- W2607238518 cites W2011309117 @default.
- W2607238518 cites W2011888952 @default.
- W2607238518 cites W2017971979 @default.
- W2607238518 cites W2019662166 @default.
- W2607238518 cites W2020202175 @default.
- W2607238518 cites W2021502847 @default.
- W2607238518 cites W2022461628 @default.
- W2607238518 cites W2024958741 @default.
- W2607238518 cites W2025003883 @default.
- W2607238518 cites W2026480269 @default.
- W2607238518 cites W2026685155 @default.
- W2607238518 cites W2027336048 @default.
- W2607238518 cites W2028064870 @default.
- W2607238518 cites W2028189987 @default.
- W2607238518 cites W2030081504 @default.
- W2607238518 cites W2032529867 @default.
- W2607238518 cites W2033445227 @default.
- W2607238518 cites W2035853632 @default.
- W2607238518 cites W2037441192 @default.
- W2607238518 cites W2039144704 @default.
- W2607238518 cites W2041216205 @default.
- W2607238518 cites W2041407510 @default.
- W2607238518 cites W2042037370 @default.
- W2607238518 cites W2043417320 @default.
- W2607238518 cites W2044151405 @default.
- W2607238518 cites W2052801968 @default.
- W2607238518 cites W2054884617 @default.
- W2607238518 cites W2055937257 @default.
- W2607238518 cites W2056766085 @default.
- W2607238518 cites W2057469265 @default.
- W2607238518 cites W2062695413 @default.
- W2607238518 cites W2063592415 @default.
- W2607238518 cites W2064225780 @default.
- W2607238518 cites W2064748241 @default.
- W2607238518 cites W2066015662 @default.
- W2607238518 cites W2068742213 @default.