Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607267685> ?p ?o ?g. }
- W2607267685 endingPage "1509" @default.
- W2607267685 startingPage "1501" @default.
- W2607267685 abstract "Piperine alkaloid, an important constituent of black pepper, exhibits numerous therapeutic properties, whereas its usage as a drug is limited due to its poor solubility in aqueous medium, which leads to poor bioavailability.Herein, a new method has been developed to improve the solubility of this drug based on the development of solid dispersions with improved dissolution rate using hydrophilic carriers such as sorbitol (Sor), polyethylene glycol (PEG) and polyvinyl pyrrolidone K30 (PVP) by solvent method. Physical mixtures of piperine and carriers were also prepared for comparison.The physicochemical properties of the prepared solid dispersions were examined using SEM, TEM, DSC, XRD and FT-IR. In vitro dissolution profile of the solid dispersions was recorded and compared with that of the pure piperine and physical mixtures. The effect of these carriers on the aqueous solubility of piperine has been investigated.The solid dispersions of piperine with Sor, PEG and PVP exhibited superior performance for the dissolution of piperine with a drug release of 70%, 76% and 89%, respectively after 2 h compared to physical mixtures and pure piperine, which could be due to its transformation from crystalline to amorphous form as well as the attachment of hydrophilic carriers to the surface of poorly water-soluble piperine.Results suggest that the piperine solid dispersions prepared with improved in vitro release exhibit potential advantage in delivering poorly water-soluble piperine as an oral supplement." @default.
- W2607267685 created "2017-04-28" @default.
- W2607267685 creator A5003715831 @default.
- W2607267685 creator A5040108669 @default.
- W2607267685 date "2017-05-05" @default.
- W2607267685 modified "2023-10-16" @default.
- W2607267685 title "Enhanced solubility of piperine using hydrophilic carrier-based potent solid dispersion systems" @default.
- W2607267685 cites W1014687656 @default.
- W2607267685 cites W1543696264 @default.
- W2607267685 cites W1797188466 @default.
- W2607267685 cites W1966471687 @default.
- W2607267685 cites W1967935934 @default.
- W2607267685 cites W1968300266 @default.
- W2607267685 cites W1969264165 @default.
- W2607267685 cites W1974449562 @default.
- W2607267685 cites W1980782557 @default.
- W2607267685 cites W1986017605 @default.
- W2607267685 cites W1988733774 @default.
- W2607267685 cites W1990847867 @default.
- W2607267685 cites W1999594077 @default.
- W2607267685 cites W2004895912 @default.
- W2607267685 cites W2008203778 @default.
- W2607267685 cites W2009076162 @default.
- W2607267685 cites W2017297841 @default.
- W2607267685 cites W2030951340 @default.
- W2607267685 cites W2033061169 @default.
- W2607267685 cites W2040432233 @default.
- W2607267685 cites W2042207765 @default.
- W2607267685 cites W2044594845 @default.
- W2607267685 cites W2047948690 @default.
- W2607267685 cites W2061709421 @default.
- W2607267685 cites W2063681189 @default.
- W2607267685 cites W2065234222 @default.
- W2607267685 cites W2066191199 @default.
- W2607267685 cites W2066615805 @default.
- W2607267685 cites W2069999158 @default.
- W2607267685 cites W2075073800 @default.
- W2607267685 cites W2079667312 @default.
- W2607267685 cites W2081833333 @default.
- W2607267685 cites W2083666950 @default.
- W2607267685 cites W2087795925 @default.
- W2607267685 cites W2089562633 @default.
- W2607267685 cites W2091742728 @default.
- W2607267685 cites W2094506063 @default.
- W2607267685 cites W2129299010 @default.
- W2607267685 cites W2149111315 @default.
- W2607267685 cites W2150508695 @default.
- W2607267685 cites W2162371396 @default.
- W2607267685 cites W2162947606 @default.
- W2607267685 cites W2398548305 @default.
- W2607267685 cites W2952528349 @default.
- W2607267685 cites W91604478 @default.
- W2607267685 doi "https://doi.org/10.1080/03639045.2017.1321658" @default.
- W2607267685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28425323" @default.
- W2607267685 hasPublicationYear "2017" @default.
- W2607267685 type Work @default.
- W2607267685 sameAs 2607267685 @default.
- W2607267685 citedByCount "27" @default.
- W2607267685 countsByYear W26072676852018 @default.
- W2607267685 countsByYear W26072676852019 @default.
- W2607267685 countsByYear W26072676852020 @default.
- W2607267685 countsByYear W26072676852021 @default.
- W2607267685 countsByYear W26072676852022 @default.
- W2607267685 countsByYear W26072676852023 @default.
- W2607267685 crossrefType "journal-article" @default.
- W2607267685 hasAuthorship W2607267685A5003715831 @default.
- W2607267685 hasAuthorship W2607267685A5040108669 @default.
- W2607267685 hasBestOaLocation W26072676852 @default.
- W2607267685 hasConcept C101335993 @default.
- W2607267685 hasConcept C10138342 @default.
- W2607267685 hasConcept C127413603 @default.
- W2607267685 hasConcept C13965031 @default.
- W2607267685 hasConcept C155574463 @default.
- W2607267685 hasConcept C15920480 @default.
- W2607267685 hasConcept C162324750 @default.
- W2607267685 hasConcept C178790620 @default.
- W2607267685 hasConcept C181389837 @default.
- W2607267685 hasConcept C184651966 @default.
- W2607267685 hasConcept C185592680 @default.
- W2607267685 hasConcept C192562407 @default.
- W2607267685 hasConcept C2776964284 @default.
- W2607267685 hasConcept C2780077769 @default.
- W2607267685 hasConcept C2780133158 @default.
- W2607267685 hasConcept C2780471494 @default.
- W2607267685 hasConcept C42360764 @default.
- W2607267685 hasConcept C43617362 @default.
- W2607267685 hasConcept C521977710 @default.
- W2607267685 hasConcept C54400483 @default.
- W2607267685 hasConcept C71924100 @default.
- W2607267685 hasConcept C77281830 @default.
- W2607267685 hasConcept C88380143 @default.
- W2607267685 hasConcept C98274493 @default.
- W2607267685 hasConceptScore W2607267685C101335993 @default.
- W2607267685 hasConceptScore W2607267685C10138342 @default.
- W2607267685 hasConceptScore W2607267685C127413603 @default.
- W2607267685 hasConceptScore W2607267685C13965031 @default.
- W2607267685 hasConceptScore W2607267685C155574463 @default.
- W2607267685 hasConceptScore W2607267685C15920480 @default.