FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607345028> ?p ?o ?g. }

• W2607345028 abstract "Lipoxin A 4 (LXA 4 ) and scrum amyloid A (SAA) are endogenous negative and positive modulators of inflammation, respectively. Both molecules bind the shared lipoxin A 4 receptor (ALX) and elicit opposing effects on the production of inflammatory cytokines and matrix metalloproteinases. The aim of these studies is to examine the divergence of the intracellular signaling pathways triggered by lipid LXA 4 (1 nM) and protein SAA (200 nM) ligands of ALX. Phospholipase D (PLD) is a phosphohydrolase enzyme that catalyzes the generation of phosphatidic acid (PA) from membrane phospholipids. Our results showed that in fibroblast-like synoviocytes, activation of PLD occurred only in response to LXA 4 , and not SAA. PA (30 μM) mimicked LXA 4 and demonstrated inhibition of IL-8 production induced by SAA or interleukin-1β. In sharp contrast to LXA 4 , SAA confirmed the stimulation of IL-8 release as determined previously. Taken together, these findings suggest that two physiologic ligands sharing the common ALX receptor, LXA 4 and SAA, differentially regulate the level of PLD activation and differentially modulate IL-8. These results may have important implications for understanding the regulation of inflammatory responses under physiologic and pathological conditions." @default.
• W2607345028 created "2017-04-28" @default.
• W2607345028 creator A5004289717 @default.
• W2607345028 creator A5012966437 @default.
• W2607345028 creator A5035128462 @default.
• W2607345028 creator A5060748260 @default.
• W2607345028 creator A5069897238 @default.
• W2607345028 creator A5073883126 @default.
• W2607345028 date "2009-01-01" @default.
• W2607345028 modified "2023-09-28" @default.
• W2607345028 title "Lipoxin A4 and Serum Amyloid a Differentially Modulate Phospholipase D in Human Fibroblast-Like Synoviocytes" @default.
• W2607345028 cites W1532844137 @default.
• W2607345028 cites W1565755899 @default.
• W2607345028 cites W1591358437 @default.
• W2607345028 cites W1599007124 @default.
• W2607345028 cites W1905065356 @default.
• W2607345028 cites W1979520552 @default.
• W2607345028 cites W1989914423 @default.
• W2607345028 cites W1990524154 @default.
• W2607345028 cites W199474707 @default.
• W2607345028 cites W1995610541 @default.
• W2607345028 cites W2025245932 @default.
• W2607345028 cites W2027222105 @default.
• W2607345028 cites W2032243894 @default.
• W2607345028 cites W2056709424 @default.
• W2607345028 cites W2057017180 @default.
• W2607345028 cites W2059672480 @default.
• W2607345028 cites W2070619903 @default.
• W2607345028 cites W2073715095 @default.
• W2607345028 cites W2078938950 @default.
• W2607345028 cites W2080523865 @default.
• W2607345028 cites W2090394875 @default.
• W2607345028 cites W2092325002 @default.
• W2607345028 cites W2116099602 @default.
• W2607345028 cites W2124051584 @default.
• W2607345028 cites W2127130381 @default.
• W2607345028 cites W2129752378 @default.
• W2607345028 cites W2132342511 @default.
• W2607345028 cites W2139357620 @default.
• W2607345028 cites W2140611998 @default.
• W2607345028 cites W2162382352 @default.
• W2607345028 cites W2406869304 @default.
• W2607345028 cites W2409482561 @default.
• W2607345028 cites W2413016786 @default.
• W2607345028 cites W47237234 @default.
• W2607345028 doi "https://doi.org/10.1177/1721727x0900700102" @default.
• W2607345028 hasPublicationYear "2009" @default.
• W2607345028 type Work @default.
• W2607345028 sameAs 2607345028 @default.
• W2607345028 citedByCount "6" @default.
• W2607345028 crossrefType "journal-article" @default.
• W2607345028 hasAuthorship W2607345028A5004289717 @default.
• W2607345028 hasAuthorship W2607345028A5012966437 @default.
• W2607345028 hasAuthorship W2607345028A5035128462 @default.
• W2607345028 hasAuthorship W2607345028A5060748260 @default.
• W2607345028 hasAuthorship W2607345028A5069897238 @default.
• W2607345028 hasAuthorship W2607345028A5073883126 @default.
• W2607345028 hasConcept C12927208 @default.
• W2607345028 hasConcept C179104552 @default.
• W2607345028 hasConcept C181199279 @default.
• W2607345028 hasConcept C185592680 @default.
• W2607345028 hasConcept C202751555 @default.
• W2607345028 hasConcept C203014093 @default.
• W2607345028 hasConcept C2776551241 @default.
• W2607345028 hasConcept C2776914184 @default.
• W2607345028 hasConcept C2777633098 @default.
• W2607345028 hasConcept C2778597717 @default.
• W2607345028 hasConcept C2780381497 @default.
• W2607345028 hasConcept C2780415110 @default.
• W2607345028 hasConcept C55359608 @default.
• W2607345028 hasConcept C55493867 @default.
• W2607345028 hasConcept C6182249 @default.
• W2607345028 hasConcept C62478195 @default.
• W2607345028 hasConcept C71924100 @default.
• W2607345028 hasConcept C86803240 @default.
• W2607345028 hasConcept C95444343 @default.
• W2607345028 hasConceptScore W2607345028C12927208 @default.
• W2607345028 hasConceptScore W2607345028C179104552 @default.
• W2607345028 hasConceptScore W2607345028C181199279 @default.
• W2607345028 hasConceptScore W2607345028C185592680 @default.
• W2607345028 hasConceptScore W2607345028C202751555 @default.
• W2607345028 hasConceptScore W2607345028C203014093 @default.
• W2607345028 hasConceptScore W2607345028C2776551241 @default.
• W2607345028 hasConceptScore W2607345028C2776914184 @default.
• W2607345028 hasConceptScore W2607345028C2777633098 @default.
• W2607345028 hasConceptScore W2607345028C2778597717 @default.
• W2607345028 hasConceptScore W2607345028C2780381497 @default.
• W2607345028 hasConceptScore W2607345028C2780415110 @default.
• W2607345028 hasConceptScore W2607345028C55359608 @default.
• W2607345028 hasConceptScore W2607345028C55493867 @default.
• W2607345028 hasConceptScore W2607345028C6182249 @default.
• W2607345028 hasConceptScore W2607345028C62478195 @default.
• W2607345028 hasConceptScore W2607345028C71924100 @default.
• W2607345028 hasConceptScore W2607345028C86803240 @default.
• W2607345028 hasConceptScore W2607345028C95444343 @default.
• W2607345028 hasLocation W26073450281 @default.
• W2607345028 hasOpenAccess W2607345028 @default.
• W2607345028 hasPrimaryLocation W26073450281 @default.
• W2607345028 hasRelatedWork W113692597 @default.
• W2607345028 hasRelatedWork W1967826083 @default.

• next