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- W2607386507 abstract "Psoriasis is a chronic, inflammatory skin disease that affects 2-3 percent of the US population, yet its pathogenesis is poorly understood. The cutaneous microbiome’s interplay with the host immune system suggests that it may contribute to the development of psoriasis in genetically predisposed individuals. This study aims to characterize the psoriatic skin microbiome and understand its role in psoriasis pathogenesis. 16s rRNA sequencing of site-matched skin swabs from 8 psoriasis patients and 8 healthy controls revealed reduced alpha diversity in lesional psoriasis skin compared to controls (402 OTU’s vs. 578 OTU’s, p=0.04). At the phylum level, lesional skin had higher Firmicutes (p=0.009) and less Actinobacteria (p=0.0001) compared to controls. At the genus level, lesional skin had more Alloiococcus (p= 0.01) and Aerococcus (p= 0.01) and demonstrated a trend towards lower Propionibacterium (p=0.08) and higher Gallicola (p=0.09) compared to controls. Interestingly, Alloiococcus (p=0.003) and Gallicola (p=0.04) were also higher in non-lesional skin compared to controls. Furthermore, lesional and non-lesional skin shared an increased abundance of Acinetobacter sp., Staphylococcus pettenkoferi, and Streptococcus sp., relative to controls. Lesional and non-lesional psoriasis skin did not differ significantly in microbiome composition. These data suggest intriguing differences in the cutaneous microbiome of psoriatic individuals and healthy controls that may advance our understanding of psoriasis pathogenesis." @default.
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- W2607386507 date "2017-05-01" @default.
- W2607386507 modified "2023-10-18" @default.
- W2607386507 title "633 Role of the cutaneous microbiome in the pathogenesis of psoriasis" @default.
- W2607386507 doi "https://doi.org/10.1016/j.jid.2017.02.655" @default.
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