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- W2607398004 abstract "Non-small cell lung cancers (NSCLC) harboring anaplastic lymphoma kinase (ALK) gene rearrangements invariably develop resistance to 2nd-generation ALK inhibitors. Lorlatinib (PF-06463922) (6) is a 3rd-generation macrocyclic ALK-TKI that demonstrates many advantages over 2nd-generation ALK inhibitors. Lorlatinib has demonstrated decent kinase selectivity, promising pharmacokinetic profile, selective brain-penetration and strong antiproliferative activity in several ALK/ROS1-driven tumor models. The current review describes the activity spectrum, key events from discovery to clinical applications and the evidences that lorlatinib acts as an ALK/ROS1 inhibitor in clinical settings." @default.
- W2607398004 created "2017-04-28" @default.
- W2607398004 creator A5024193161 @default.
- W2607398004 creator A5037509365 @default.
- W2607398004 creator A5048482307 @default.
- W2607398004 creator A5081829992 @default.
- W2607398004 date "2017-07-01" @default.
- W2607398004 modified "2023-10-02" @default.
- W2607398004 title "First macrocyclic 3 rd -generation ALK inhibitor for treatment of ALK/ROS1 cancer: Clinical and designing strategy update of lorlatinib" @default.
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- W2607398004 doi "https://doi.org/10.1016/j.ejmech.2017.04.032" @default.
- W2607398004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28431340" @default.
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