FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607406266> ?p ?o ?g. }

• W2607406266 endingPage "167" @default.
• W2607406266 startingPage "159" @default.
• W2607406266 abstract "Dihydromyricetin (DMY) is one of the most important flavonoids in vine tea, which showed several pharmacological effects. However, information about the potential role of DMY on angiotensin II (Ang II) induced cardiac fibroblasts proliferation remains unknown. In the present study, cardiac fibroblasts isolated from neonatal Sprague-Dawley rats were pretreated with different concentrations of DMY (0-320μM) for 4h, or DMY (80μM) for different time (0-24h), followed by Ang II (100nM) stimulation for 24h, Then number of cardiac fibroblasts and content of hydroxyproline was measured. The level of cellular reactive oxygen species, malondialdehyde (MDA), activity of superoxide dismutase (SOD) and total antioxidant capacity (T-AOC) were also evaluated. Expression of type I, type III collagen, α-smooth muscle actin (α-SMA), p22phox (one vital subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase), SOD and thioredoxin (Trx) were detected with real time PCR or/and western blot. We found that pre-incubation with DMY (20μM, 40μM, 80μM) for 4h, 12h or 24h attenuated the proliferation of cardiac fibroblasts induced by Ang II. Expression of type I and type III collagen, as well as α-SMA were inhibited by DMY at both mRNA and protein level. DMY also significantly decreased cellular reactive oxygen species production and MDA level, while increased the SOD activity and T-AOC. DMY suppressed p22phox, while enhanced antioxidant SOD and Trx expression in Ang II stimulated cardiac fibroblasts. Thus, dihydromyricetin attenuated Ang II induced cardiac fibroblasts proliferation related to inhibitory of oxidative stress." @default.
• W2607406266 created "2017-04-28" @default.
• W2607406266 creator A5001336604 @default.
• W2607406266 creator A5003256823 @default.
• W2607406266 creator A5007147866 @default.
• W2607406266 creator A5040378988 @default.
• W2607406266 creator A5041633536 @default.
• W2607406266 creator A5053979421 @default.
• W2607406266 creator A5080042902 @default.
• W2607406266 creator A5086808988 @default.
• W2607406266 creator A5089136469 @default.
• W2607406266 date "2017-07-01" @default.
• W2607406266 modified "2023-10-16" @default.
• W2607406266 title "Dihydromyricetin attenuated Ang II induced cardiac fibroblasts proliferation related to inhibitory of oxidative stress" @default.
• W2607406266 cites W1593096883 @default.
• W2607406266 cites W1880545972 @default.
• W2607406266 cites W1930799289 @default.
• W2607406266 cites W1946295703 @default.
• W2607406266 cites W1955400364 @default.
• W2607406266 cites W1970367041 @default.
• W2607406266 cites W1972183542 @default.
• W2607406266 cites W1975856746 @default.
• W2607406266 cites W1978215074 @default.
• W2607406266 cites W1978827335 @default.
• W2607406266 cites W1981096943 @default.
• W2607406266 cites W1985561691 @default.
• W2607406266 cites W1994222503 @default.
• W2607406266 cites W1999637718 @default.
• W2607406266 cites W2002949994 @default.
• W2607406266 cites W2011521489 @default.
• W2607406266 cites W2012379094 @default.
• W2607406266 cites W2012568931 @default.
• W2607406266 cites W2018414956 @default.
• W2607406266 cites W2050862994 @default.
• W2607406266 cites W2054684876 @default.
• W2607406266 cites W2056878256 @default.
• W2607406266 cites W2060480383 @default.
• W2607406266 cites W2066373714 @default.
• W2607406266 cites W2077149632 @default.
• W2607406266 cites W2077435190 @default.
• W2607406266 cites W2082278578 @default.
• W2607406266 cites W2085463378 @default.
• W2607406266 cites W2091785209 @default.
• W2607406266 cites W2112666637 @default.
• W2607406266 cites W2116268698 @default.
• W2607406266 cites W2134720857 @default.
• W2607406266 cites W2146259508 @default.
• W2607406266 cites W2157175793 @default.
• W2607406266 cites W2171101739 @default.
• W2607406266 cites W2236726106 @default.
• W2607406266 cites W2249909287 @default.
• W2607406266 cites W2282914400 @default.
• W2607406266 cites W2312517444 @default.
• W2607406266 cites W2312759407 @default.
• W2607406266 cites W2394892669 @default.
• W2607406266 cites W2402928538 @default.
• W2607406266 cites W2411482377 @default.
• W2607406266 cites W2507516362 @default.
• W2607406266 cites W2508816438 @default.
• W2607406266 cites W2514331094 @default.
• W2607406266 cites W2518476176 @default.
• W2607406266 cites W2531638413 @default.
• W2607406266 cites W2573527815 @default.
• W2607406266 cites W604783079 @default.
• W2607406266 doi "https://doi.org/10.1016/j.ejphar.2017.04.014" @default.
• W2607406266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28414055" @default.
• W2607406266 hasPublicationYear "2017" @default.
• W2607406266 type Work @default.
• W2607406266 sameAs 2607406266 @default.
• W2607406266 citedByCount "44" @default.
• W2607406266 countsByYear W26074062662017 @default.
• W2607406266 countsByYear W26074062662018 @default.
• W2607406266 countsByYear W26074062662019 @default.
• W2607406266 countsByYear W26074062662020 @default.
• W2607406266 countsByYear W26074062662021 @default.
• W2607406266 countsByYear W26074062662022 @default.
• W2607406266 countsByYear W26074062662023 @default.
• W2607406266 crossrefType "journal-article" @default.
• W2607406266 hasAuthorship W2607406266A5001336604 @default.
• W2607406266 hasAuthorship W2607406266A5003256823 @default.
• W2607406266 hasAuthorship W2607406266A5007147866 @default.
• W2607406266 hasAuthorship W2607406266A5040378988 @default.
• W2607406266 hasAuthorship W2607406266A5041633536 @default.
• W2607406266 hasAuthorship W2607406266A5053979421 @default.
• W2607406266 hasAuthorship W2607406266A5080042902 @default.
• W2607406266 hasAuthorship W2607406266A5086808988 @default.
• W2607406266 hasAuthorship W2607406266A5089136469 @default.
• W2607406266 hasConcept C104317684 @default.
• W2607406266 hasConcept C126322002 @default.
• W2607406266 hasConcept C134018914 @default.
• W2607406266 hasConcept C181199279 @default.
• W2607406266 hasConcept C185592680 @default.
• W2607406266 hasConcept C2775838275 @default.
• W2607406266 hasConcept C2776151105 @default.
• W2607406266 hasConcept C2776415932 @default.
• W2607406266 hasConcept C2777989768 @default.
• W2607406266 hasConcept C2778004101 @default.
• W2607406266 hasConcept C2778401633 @default.

• next