Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607510433> ?p ?o ?g. }
- W2607510433 endingPage "354" @default.
- W2607510433 startingPage "340" @default.
- W2607510433 abstract "S-nitrosoglutathione reductase (GSNOR), or ADH5, is an enzyme in the alcohol dehydrogenase (ADH) family. It is unique when compared to other ADH enzymes in that primary short-chain alcohols are not its principle substrate. GSNOR metabolizes S-nitrosoglutathione (GSNO), S-hydroxymethylglutathione (the spontaneous adduct of formaldehyde and glutathione), and some alcohols. GSNOR modulates reactive nitric oxide (•NO) availability in the cell by catalyzing the breakdown of GSNO, and indirectly regulates S-nitrosothiols (RSNOs) through GSNO-mediated protein S-nitrosation. The dysregulation of GSNOR can significantly alter cellular homeostasis, leading to disease. GSNOR plays an important regulatory role in smooth muscle relaxation, immune function, inflammation, neuronal development and cancer progression, among many other processes. In recent years, the therapeutic inhibition of GSNOR has been investigated to treat asthma, cystic fibrosis and interstitial lung disease (ILD). The direct action of •NO on cellular pathways, as well as the important regulatory role of protein S-nitrosation, is closely tied to GSNOR regulation and defines this enzyme as an important therapeutic target." @default.
- W2607510433 created "2017-04-28" @default.
- W2607510433 creator A5000236754 @default.
- W2607510433 creator A5028222065 @default.
- W2607510433 date "2017-04-10" @default.
- W2607510433 modified "2023-10-17" @default.
- W2607510433 title "The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy" @default.
- W2607510433 cites W144243801 @default.
- W2607510433 cites W1488493608 @default.
- W2607510433 cites W1500094754 @default.
- W2607510433 cites W1514745995 @default.
- W2607510433 cites W1528557278 @default.
- W2607510433 cites W1555506213 @default.
- W2607510433 cites W1567418767 @default.
- W2607510433 cites W1586297699 @default.
- W2607510433 cites W1598978469 @default.
- W2607510433 cites W1605189715 @default.
- W2607510433 cites W1688534084 @default.
- W2607510433 cites W1750684951 @default.
- W2607510433 cites W1803760021 @default.
- W2607510433 cites W1821918060 @default.
- W2607510433 cites W1844185706 @default.
- W2607510433 cites W1857196095 @default.
- W2607510433 cites W1918392102 @default.
- W2607510433 cites W1929009802 @default.
- W2607510433 cites W1953621264 @default.
- W2607510433 cites W1965988753 @default.
- W2607510433 cites W1966295500 @default.
- W2607510433 cites W1966338358 @default.
- W2607510433 cites W1966466376 @default.
- W2607510433 cites W1966824889 @default.
- W2607510433 cites W1967969693 @default.
- W2607510433 cites W1969916539 @default.
- W2607510433 cites W1970169137 @default.
- W2607510433 cites W1976207992 @default.
- W2607510433 cites W1976274851 @default.
- W2607510433 cites W1979611175 @default.
- W2607510433 cites W1982536922 @default.
- W2607510433 cites W1985289402 @default.
- W2607510433 cites W1986320888 @default.
- W2607510433 cites W1986542934 @default.
- W2607510433 cites W1987602656 @default.
- W2607510433 cites W1988734169 @default.
- W2607510433 cites W1988769536 @default.
- W2607510433 cites W1989611868 @default.
- W2607510433 cites W1990502679 @default.
- W2607510433 cites W1991275862 @default.
- W2607510433 cites W1991358947 @default.
- W2607510433 cites W1997382890 @default.
- W2607510433 cites W1998329406 @default.
- W2607510433 cites W1999087985 @default.
- W2607510433 cites W1999819498 @default.
- W2607510433 cites W2000322479 @default.
- W2607510433 cites W2000825076 @default.
- W2607510433 cites W2001093390 @default.
- W2607510433 cites W2003379664 @default.
- W2607510433 cites W2003683297 @default.
- W2607510433 cites W2003946735 @default.
- W2607510433 cites W2004649932 @default.
- W2607510433 cites W2006946214 @default.
- W2607510433 cites W2012455477 @default.
- W2607510433 cites W2013023382 @default.
- W2607510433 cites W2014433643 @default.
- W2607510433 cites W2017944586 @default.
- W2607510433 cites W2018101787 @default.
- W2607510433 cites W2018818498 @default.
- W2607510433 cites W2020070525 @default.
- W2607510433 cites W2020879834 @default.
- W2607510433 cites W2021723651 @default.
- W2607510433 cites W2022190551 @default.
- W2607510433 cites W2022590238 @default.
- W2607510433 cites W2022835362 @default.
- W2607510433 cites W2023446937 @default.
- W2607510433 cites W2024559949 @default.
- W2607510433 cites W2024953155 @default.
- W2607510433 cites W2025996212 @default.
- W2607510433 cites W2026585864 @default.
- W2607510433 cites W2028711149 @default.
- W2607510433 cites W2033993671 @default.
- W2607510433 cites W2034593279 @default.
- W2607510433 cites W2037593344 @default.
- W2607510433 cites W2038074753 @default.
- W2607510433 cites W2038391384 @default.
- W2607510433 cites W2039483114 @default.
- W2607510433 cites W2040852689 @default.
- W2607510433 cites W2041162400 @default.
- W2607510433 cites W2043700110 @default.
- W2607510433 cites W2045807922 @default.
- W2607510433 cites W2045812417 @default.
- W2607510433 cites W2046818698 @default.
- W2607510433 cites W2047688401 @default.
- W2607510433 cites W2047832965 @default.
- W2607510433 cites W2048005287 @default.
- W2607510433 cites W2050902903 @default.
- W2607510433 cites W2053986530 @default.
- W2607510433 cites W2055403815 @default.
- W2607510433 cites W2055809007 @default.
- W2607510433 cites W2056197807 @default.