FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607567876> ?p ?o ?g. }

• W2607567876 endingPage "e1312240" @default.
• W2607567876 startingPage "e1312240" @default.
• W2607567876 abstract "Programmed death ligand 1 (PD-L1) expression represents a mechanism of immune escape by inhibiting T cell immunity. This study systematically evaluated the expression of PD-L1, spatial distribution of CD3+ immune cells and the relationship of both factors to survival in nasopharyngeal carcinoma (NPC) patients. A total of 209 NPC patients treated between 1991 and 2000 were included. Pairs of TMAs were immunohistochemically stained with PD-L1 and CD3. Survival analysis was evaluated according to PD-L1 status and the spatial distribution of CD3+ immune cells in the primary lesion microenvironment. PD-L1 staining was observed on tumor cells and tumor-infiltrating immune cells (TILs); however, PD-L1-positive immune cells were more common (98/209) than PD-L1-positive tumor cells (68/209). Limited numbers of intra-tumoral CD3+ T cells (median number: 20) were detected. Patients with higher CD3+ T cell infiltration, both intratumorally and peritumorally, had higher PD-L1 expression on tumor cells (both p < 0.001) and immune cells (p = 0.002 and p < 0.001, respectively). Increasing intratumoral CD3 infiltration was correlated with increased overall survival (OS) (p = 0.008) and disease-free survival (DFS) (p = 0.003). Nevertheless, patients with low levels of peritumoral TILs showed superior OS (p = 0.557) and DFS to those with higher levels of peritumoral TILs (p = 0.671). Moreover, type classification based on intratumoral CD3 infiltration and tumor cell PD-L1 expression was an independent prognostic factor for NPC patients. PD-L1 expression on tumor cells is a favorable prognosis factor in NPC patients with pre-existing intratumor-infiltrating lymphocytes." @default.
• W2607567876 created "2017-05-05" @default.
• W2607567876 creator A5019646129 @default.
• W2607567876 creator A5020282017 @default.
• W2607567876 creator A5040048515 @default.
• W2607567876 creator A5045689266 @default.
• W2607567876 creator A5049796978 @default.
• W2607567876 creator A5052024256 @default.
• W2607567876 creator A5061152137 @default.
• W2607567876 creator A5062511001 @default.
• W2607567876 creator A5069689440 @default.
• W2607567876 creator A5074169809 @default.
• W2607567876 date "2017-05-04" @default.
• W2607567876 modified "2023-09-24" @default.
• W2607567876 title "Tumor cells PD-L1 expression as a favorable prognosis factor in nasopharyngeal carcinoma patients with pre-existing intratumor-infiltrating lymphocytes" @default.
• W2607567876 cites W1889335134 @default.
• W2607567876 cites W1971208896 @default.
• W2607567876 cites W1982488143 @default.
• W2607567876 cites W1995532992 @default.
• W2607567876 cites W1999560798 @default.
• W2607567876 cites W2013090484 @default.
• W2607567876 cites W2017286592 @default.
• W2607567876 cites W2022022413 @default.
• W2607567876 cites W2025798666 @default.
• W2607567876 cites W2039123767 @default.
• W2607567876 cites W2050302729 @default.
• W2607567876 cites W2057893793 @default.
• W2607567876 cites W2062952095 @default.
• W2607567876 cites W2066671159 @default.
• W2607567876 cites W2074942026 @default.
• W2607567876 cites W2078197336 @default.
• W2607567876 cites W2087949560 @default.
• W2607567876 cites W2090830065 @default.
• W2607567876 cites W2097995306 @default.
• W2607567876 cites W2099432296 @default.
• W2607567876 cites W2104350866 @default.
• W2607567876 cites W2106347414 @default.
• W2607567876 cites W2109485845 @default.
• W2607567876 cites W2111161262 @default.
• W2607567876 cites W2111247797 @default.
• W2607567876 cites W2118982164 @default.
• W2607567876 cites W2120426523 @default.
• W2607567876 cites W2124427232 @default.
• W2607567876 cites W2130207101 @default.
• W2607567876 cites W2133155105 @default.
• W2607567876 cites W2136731993 @default.
• W2607567876 cites W2136964874 @default.
• W2607567876 cites W2137967850 @default.
• W2607567876 cites W2141269240 @default.
• W2607567876 cites W2149003918 @default.
• W2607567876 cites W2154270347 @default.
• W2607567876 cites W2160834915 @default.
• W2607567876 cites W2165625761 @default.
• W2607567876 cites W2171622769 @default.
• W2607567876 cites W2298299219 @default.
• W2607567876 cites W2493219106 @default.
• W2607567876 cites W2564961580 @default.
• W2607567876 doi "https://doi.org/10.1080/2162402x.2017.1312240" @default.
• W2607567876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5467992" @default.
• W2607567876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28638740" @default.
• W2607567876 hasPublicationYear "2017" @default.
• W2607567876 type Work @default.
• W2607567876 sameAs 2607567876 @default.
• W2607567876 citedByCount "61" @default.
• W2607567876 countsByYear W26075678762018 @default.
• W2607567876 countsByYear W26075678762019 @default.
• W2607567876 countsByYear W26075678762020 @default.
• W2607567876 countsByYear W26075678762021 @default.
• W2607567876 countsByYear W26075678762022 @default.
• W2607567876 countsByYear W26075678762023 @default.
• W2607567876 crossrefType "journal-article" @default.
• W2607567876 hasAuthorship W2607567876A5019646129 @default.
• W2607567876 hasAuthorship W2607567876A5020282017 @default.
• W2607567876 hasAuthorship W2607567876A5040048515 @default.
• W2607567876 hasAuthorship W2607567876A5045689266 @default.
• W2607567876 hasAuthorship W2607567876A5049796978 @default.
• W2607567876 hasAuthorship W2607567876A5052024256 @default.
• W2607567876 hasAuthorship W2607567876A5061152137 @default.
• W2607567876 hasAuthorship W2607567876A5062511001 @default.
• W2607567876 hasAuthorship W2607567876A5069689440 @default.
• W2607567876 hasAuthorship W2607567876A5074169809 @default.
• W2607567876 hasBestOaLocation W26075678761 @default.
• W2607567876 hasConcept C114684123 @default.
• W2607567876 hasConcept C121332964 @default.
• W2607567876 hasConcept C126322002 @default.
• W2607567876 hasConcept C142724271 @default.
• W2607567876 hasConcept C153400128 @default.
• W2607567876 hasConcept C167672396 @default.
• W2607567876 hasConcept C203014093 @default.
• W2607567876 hasConcept C204232928 @default.
• W2607567876 hasConcept C2776107976 @default.
• W2607567876 hasConcept C2777701055 @default.
• W2607567876 hasConcept C2778326572 @default.
• W2607567876 hasConcept C2778997737 @default.
• W2607567876 hasConcept C2781053074 @default.
• W2607567876 hasConcept C502942594 @default.
• W2607567876 hasConcept C509974204 @default.
• W2607567876 hasConcept C71924100 @default.

• next