Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607580726> ?p ?o ?g. }
- W2607580726 abstract "Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases. However, little is known about the significance of increased plasma MMP9 in patients with perioperative myocardial injury. We aimed to investigate the role of MMP9 in the occurrence of myocardial injury during off-pump coronary artery bypass grafting (OPCAB).A total of 34 consecutive patients with coronary artery diseases (CAD) were recruited in this prospective, observational study. All patients were operated for OPCAB surgery. Serial blood samples were collected preoperatively and 12 hours after surgery. MMP9, together with cardiac troponin I (cTnI), creatinine kinase myocardial b fraction (CK-MB), C-reactive protein (CRP), and N-terminal pro B-type natriuretic peptide (NT-proBNP) levels in plasma were measured at each time-point.MMP9 levels increased significantly at 12 hours after surgery, attaining nearly 2 times the baseline levels (P=0.0001). There was a significant correlation between preoperative (pre-OP) circulating levels of MMP9 and the left ventricular ejection fraction (LVEF) (r=0.48; P=0.004) as well as European System for Cardiac Operative Risk Evaluation (EuroSCORE) II (r=0.43; P=0.012). Patients were in New York Heart Association (NYHA) functional class III or IV heart failure showed a significantly higher MMP9 levels (1,348.0±337.2 vs. 630.4±93.0 ng/L, P=0.012) as compared to the patients in NYHA functional class I and II. No significant correlation was observed between MMP9 and age (P=0.612), serum creatinine (P=0.185), CRP (P=0.207), NT-proBNP (P=0.058). A significant correlation was observed in these data between the post-OP MMP9 and cTnI (r=0.35; P=0.003).Our study first established a connection between MMP9 and OPCAB procedure, suggesting that MMP9 could be a novel biomarker for identifying perioperative myocardial injury in patients undergoing OPCAB." @default.
- W2607580726 created "2017-05-05" @default.
- W2607580726 creator A5000045667 @default.
- W2607580726 creator A5001657111 @default.
- W2607580726 creator A5027835055 @default.
- W2607580726 creator A5029200595 @default.
- W2607580726 creator A5035759428 @default.
- W2607580726 creator A5036614817 @default.
- W2607580726 creator A5037344891 @default.
- W2607580726 creator A5064993000 @default.
- W2607580726 creator A5074215052 @default.
- W2607580726 creator A5083815488 @default.
- W2607580726 creator A5091145559 @default.
- W2607580726 date "2017-04-01" @default.
- W2607580726 modified "2023-09-24" @default.
- W2607580726 title "Plasma levels of matrix metalloproteinase 9 in patients undergoing off-pump coronary artery bypass grafting" @default.
- W2607580726 cites W1905017519 @default.
- W2607580726 cites W1977111128 @default.
- W2607580726 cites W1978404036 @default.
- W2607580726 cites W1987699364 @default.
- W2607580726 cites W1989487236 @default.
- W2607580726 cites W1993804921 @default.
- W2607580726 cites W2008587727 @default.
- W2607580726 cites W2019349022 @default.
- W2607580726 cites W2020982843 @default.
- W2607580726 cites W2023647145 @default.
- W2607580726 cites W2029658231 @default.
- W2607580726 cites W2043355876 @default.
- W2607580726 cites W2071651599 @default.
- W2607580726 cites W2092795012 @default.
- W2607580726 cites W2106834148 @default.
- W2607580726 cites W2124267928 @default.
- W2607580726 cites W2136718447 @default.
- W2607580726 cites W2147065016 @default.
- W2607580726 cites W2149376322 @default.
- W2607580726 cites W2154401382 @default.
- W2607580726 cites W2161866878 @default.
- W2607580726 cites W2186403688 @default.
- W2607580726 cites W2279664117 @default.
- W2607580726 cites W2285460778 @default.
- W2607580726 doi "https://doi.org/10.21037/jtd.2017.03.156" @default.
- W2607580726 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5418257" @default.
- W2607580726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28523165" @default.
- W2607580726 hasPublicationYear "2017" @default.
- W2607580726 type Work @default.
- W2607580726 sameAs 2607580726 @default.
- W2607580726 citedByCount "1" @default.
- W2607580726 countsByYear W26075807262020 @default.
- W2607580726 crossrefType "journal-article" @default.
- W2607580726 hasAuthorship W2607580726A5000045667 @default.
- W2607580726 hasAuthorship W2607580726A5001657111 @default.
- W2607580726 hasAuthorship W2607580726A5027835055 @default.
- W2607580726 hasAuthorship W2607580726A5029200595 @default.
- W2607580726 hasAuthorship W2607580726A5035759428 @default.
- W2607580726 hasAuthorship W2607580726A5036614817 @default.
- W2607580726 hasAuthorship W2607580726A5037344891 @default.
- W2607580726 hasAuthorship W2607580726A5064993000 @default.
- W2607580726 hasAuthorship W2607580726A5074215052 @default.
- W2607580726 hasAuthorship W2607580726A5083815488 @default.
- W2607580726 hasAuthorship W2607580726A5091145559 @default.
- W2607580726 hasBestOaLocation W26075807262 @default.
- W2607580726 hasConcept C115725540 @default.
- W2607580726 hasConcept C126322002 @default.
- W2607580726 hasConcept C141071460 @default.
- W2607580726 hasConcept C164705383 @default.
- W2607580726 hasConcept C2775846464 @default.
- W2607580726 hasConcept C2775915353 @default.
- W2607580726 hasConcept C2776820930 @default.
- W2607580726 hasConcept C2778198053 @default.
- W2607580726 hasConcept C2779040412 @default.
- W2607580726 hasConcept C2780306776 @default.
- W2607580726 hasConcept C31174226 @default.
- W2607580726 hasConcept C500558357 @default.
- W2607580726 hasConcept C71924100 @default.
- W2607580726 hasConcept C78085059 @default.
- W2607580726 hasConceptScore W2607580726C115725540 @default.
- W2607580726 hasConceptScore W2607580726C126322002 @default.
- W2607580726 hasConceptScore W2607580726C141071460 @default.
- W2607580726 hasConceptScore W2607580726C164705383 @default.
- W2607580726 hasConceptScore W2607580726C2775846464 @default.
- W2607580726 hasConceptScore W2607580726C2775915353 @default.
- W2607580726 hasConceptScore W2607580726C2776820930 @default.
- W2607580726 hasConceptScore W2607580726C2778198053 @default.
- W2607580726 hasConceptScore W2607580726C2779040412 @default.
- W2607580726 hasConceptScore W2607580726C2780306776 @default.
- W2607580726 hasConceptScore W2607580726C31174226 @default.
- W2607580726 hasConceptScore W2607580726C500558357 @default.
- W2607580726 hasConceptScore W2607580726C71924100 @default.
- W2607580726 hasConceptScore W2607580726C78085059 @default.
- W2607580726 hasLocation W26075807261 @default.
- W2607580726 hasLocation W26075807262 @default.
- W2607580726 hasLocation W26075807263 @default.
- W2607580726 hasLocation W26075807264 @default.
- W2607580726 hasOpenAccess W2607580726 @default.
- W2607580726 hasPrimaryLocation W26075807261 @default.
- W2607580726 hasRelatedWork W2328354663 @default.
- W2607580726 hasRelatedWork W2353635656 @default.
- W2607580726 hasRelatedWork W2355594703 @default.
- W2607580726 hasRelatedWork W2359620487 @default.
- W2607580726 hasRelatedWork W2372642635 @default.