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• W2607608758 abstract "Background The liability-threshold model of psychosis risk predicts stronger phenotypic manifestation of the polygenic risk score (PRS) in the healthy relatives of patients, as compared with healthy comparison subjects. Methods First-degree relatives of patients with psychotic disorder (871 siblings and 812 parents) and healthy comparison subjects ( n = 523) were interviewed three times in 6 years. Repeated measures of two psychosis phenotypes, the Community Assessment of Psychic Experiences (CAPE; self-report – subscales of positive, negative and depressive symptoms) and the Structured Interview for Schizotypy – Revised (SIS-R; clinical interview – subscales of positive and negative schizotypy), were examined for association with PRS. Interview-based lifetime rate of depressive and manic episodes were also examined, as was association with repeated measures of intelligence quotient (IQ). Results In the relatives, PRS was associated with CAPE/SIS-R total score (respectively, B = 0.12, 95% CI 0.02–0.22 and B = 0.11, 95% CI 0.02–0.20), the SIS-R positive subscale ( B = 0.16, 95% CI 0.04–0.28), the CAPE depression subscale ( B = 0.21, 95% CI 0.07–0.34), any lifetime affective episode (OR 3.1, 95% CI 1.04–9.3), but not with IQ ( B = −1.8, 95% CI −8.0 to 4.4). In the controls, similar associations were apparent between PRS on the one hand and SIS-R total score, SIS-R positive, SIS-R negative, any lifetime affective episode and, in contrast, lower IQ ( B = −8.5, 95% CI −15.5 to −1.6). Conclusions In non-ill people, polygenic risk for psychotic disorder is expressed pleiotropically in the domain of neurodevelopment, emotion regulation and attribution of salience. In subjects at elevated genetic risk, emerging expression of neurodevelopmental alterations may create floor effects, obscuring genetic associations." @default.
• W2607608758 created "2017-05-05" @default.
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• W2607608758 date "2017-04-24" @default.
• W2607608758 modified "2023-09-26" @default.
• W2607608758 title "Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience" @default.
• W2607608758 cites W1600258269 @default.
• W2607608758 cites W1633838156 @default.
• W2607608758 cites W1946774659 @default.
• W2607608758 cites W1967348227 @default.
• W2607608758 cites W1968190574 @default.
• W2607608758 cites W1979068472 @default.
• W2607608758 cites W1986490348 @default.
• W2607608758 cites W1989893823 @default.
• W2607608758 cites W1998233837 @default.
• W2607608758 cites W2001478554 @default.
• W2607608758 cites W2002777508 @default.
• W2607608758 cites W2002788019 @default.
• W2607608758 cites W2004410453 @default.
• W2607608758 cites W2014044116 @default.
• W2607608758 cites W2019206689 @default.
• W2607608758 cites W2019410645 @default.
• W2607608758 cites W2020206700 @default.
• W2607608758 cites W2024533281 @default.
• W2607608758 cites W2025156429 @default.
• W2607608758 cites W2028466261 @default.
• W2607608758 cites W2028576417 @default.
• W2607608758 cites W2031452907 @default.
• W2607608758 cites W2042324812 @default.
• W2607608758 cites W2045227722 @default.
• W2607608758 cites W2046694931 @default.
• W2607608758 cites W2052963268 @default.
• W2607608758 cites W2052998051 @default.
• W2607608758 cites W2059346532 @default.
• W2607608758 cites W2076638182 @default.
• W2607608758 cites W2084865691 @default.
• W2607608758 cites W2089854473 @default.
• W2607608758 cites W2089868642 @default.
• W2607608758 cites W2097810958 @default.
• W2607608758 cites W2098597355 @default.
• W2607608758 cites W2099759568 @default.
• W2607608758 cites W2101357408 @default.
• W2607608758 cites W2105347849 @default.
• W2607608758 cites W2110048796 @default.
• W2607608758 cites W2110740936 @default.
• W2607608758 cites W2112242691 @default.
• W2607608758 cites W2112406414 @default.
• W2607608758 cites W2116255924 @default.
• W2607608758 cites W2118981668 @default.
• W2607608758 cites W2120839417 @default.
• W2607608758 cites W2121532026 @default.
• W2607608758 cites W2124529293 @default.
• W2607608758 cites W2126397158 @default.
• W2607608758 cites W2131974041 @default.
• W2607608758 cites W2132803173 @default.
• W2607608758 cites W2139852368 @default.
• W2607608758 cites W2140280664 @default.
• W2607608758 cites W2145545300 @default.
• W2607608758 cites W2145784428 @default.
• W2607608758 cites W2149783607 @default.
• W2607608758 cites W2150679389 @default.
• W2607608758 cites W2156835379 @default.
• W2607608758 cites W2157752701 @default.
• W2607608758 cites W2162176680 @default.
• W2607608758 cites W2164534384 @default.
• W2607608758 cites W2220858926 @default.
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• W2607608758 cites W2265828636 @default.
• W2607608758 cites W2338110383 @default.
• W2607608758 cites W2442768873 @default.
• W2607608758 cites W2511515754 @default.
• W2607608758 cites W2586855575 @default.
• W2607608758 cites W33021784 @default.
• W2607608758 cites W4375938069 @default.
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• W2607608758 doi "https://doi.org/10.1017/s0033291717000915" @default.
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