Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607628579> ?p ?o ?g. }
- W2607628579 endingPage "45980" @default.
- W2607628579 startingPage "45965" @default.
- W2607628579 abstract "// Jingjing Li 1 , Kan Chen 1 , Fan Wang 1 , Weiqi Dai 1 , Sainan Li 1 , Jiao Feng 1 , Liwei Wu 1 , Tong Liu 1 , Shizan Xu 1, 2 , Yujing Xia 1 , Jie Lu 1 , Yingqun Zhou 1 , Ling Xu 3 and Chuanyong Guo 1 1 Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China 2 Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China 3 Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China Correspondence to: Ling Xu, email: xiaoling05@126.com Chuanyong Guo, email: guochuanyong@hotmail.com Keywords: Warburg effect, hexokinase 2, hepatoma, methyl jasmonate, glycolysis Received: December 14, 2016 Accepted: April 11, 2017 Published: April 27, 2017 ABSTRACT Methyl jasmonate has recently been found to have anti-cancer activity. Methyl jasmonate detached hexokinase 2 from a voltage dependent anion channel causing a reduction in mitochondrial transmembrane potential that led to the release of cytochrome C and apoptosis inducing factor resulting in intrinsic apoptosis. Blocked adenosine triphosphate synthesis caused by mitochondrial injury hampered oxidative phosphorylation and led to cell necrosis. The results were applied to the in vivo treatment of nude mice with a satisfactory effect. Collectively, our results suggest that methyl jasmonate may be an adjuvant therapy for liver tumors due to its mechanism in cancer cells compared to that in normal cells: The major function is to inhibit glycolysis instead of changing aerobic metabolism." @default.
- W2607628579 created "2017-05-05" @default.
- W2607628579 creator A5000441787 @default.
- W2607628579 creator A5013617878 @default.
- W2607628579 creator A5014920577 @default.
- W2607628579 creator A5018305440 @default.
- W2607628579 creator A5027134161 @default.
- W2607628579 creator A5027721650 @default.
- W2607628579 creator A5037249009 @default.
- W2607628579 creator A5038836690 @default.
- W2607628579 creator A5046775442 @default.
- W2607628579 creator A5048077073 @default.
- W2607628579 creator A5067291339 @default.
- W2607628579 creator A5080196380 @default.
- W2607628579 creator A5083487683 @default.
- W2607628579 creator A5090473887 @default.
- W2607628579 date "2017-04-27" @default.
- W2607628579 modified "2023-10-11" @default.
- W2607628579 title "Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice" @default.
- W2607628579 cites W1275087818 @default.
- W2607628579 cites W1486720764 @default.
- W2607628579 cites W1599863157 @default.
- W2607628579 cites W1876591066 @default.
- W2607628579 cites W1916235144 @default.
- W2607628579 cites W1964483580 @default.
- W2607628579 cites W1975610204 @default.
- W2607628579 cites W1986052935 @default.
- W2607628579 cites W1986733939 @default.
- W2607628579 cites W1997249253 @default.
- W2607628579 cites W2008351667 @default.
- W2607628579 cites W2014603256 @default.
- W2607628579 cites W2022211348 @default.
- W2607628579 cites W2026185978 @default.
- W2607628579 cites W2027510137 @default.
- W2607628579 cites W2031196135 @default.
- W2607628579 cites W2034269086 @default.
- W2607628579 cites W2042358042 @default.
- W2607628579 cites W2052543023 @default.
- W2607628579 cites W2055309496 @default.
- W2607628579 cites W2057713121 @default.
- W2607628579 cites W2062897750 @default.
- W2607628579 cites W2072451938 @default.
- W2607628579 cites W2079156263 @default.
- W2607628579 cites W2105665764 @default.
- W2607628579 cites W2111541751 @default.
- W2607628579 cites W2115268409 @default.
- W2607628579 cites W2119683782 @default.
- W2607628579 cites W2124280040 @default.
- W2607628579 cites W2127324182 @default.
- W2607628579 cites W2128276727 @default.
- W2607628579 cites W2131052402 @default.
- W2607628579 cites W2144569256 @default.
- W2607628579 cites W2155098156 @default.
- W2607628579 cites W2156943914 @default.
- W2607628579 cites W2163074858 @default.
- W2607628579 cites W2171180960 @default.
- W2607628579 cites W2276797565 @default.
- W2607628579 cites W2304994032 @default.
- W2607628579 cites W2331487308 @default.
- W2607628579 cites W2334472445 @default.
- W2607628579 cites W2338144449 @default.
- W2607628579 cites W2401083434 @default.
- W2607628579 cites W2406086382 @default.
- W2607628579 cites W2466923815 @default.
- W2607628579 cites W2478894620 @default.
- W2607628579 cites W2534319537 @default.
- W2607628579 doi "https://doi.org/10.18632/oncotarget.17469" @default.
- W2607628579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5542241" @default.
- W2607628579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28498814" @default.
- W2607628579 hasPublicationYear "2017" @default.
- W2607628579 type Work @default.
- W2607628579 sameAs 2607628579 @default.
- W2607628579 citedByCount "25" @default.
- W2607628579 countsByYear W26076285792018 @default.
- W2607628579 countsByYear W26076285792019 @default.
- W2607628579 countsByYear W26076285792020 @default.
- W2607628579 countsByYear W26076285792021 @default.
- W2607628579 countsByYear W26076285792022 @default.
- W2607628579 countsByYear W26076285792023 @default.
- W2607628579 crossrefType "journal-article" @default.
- W2607628579 hasAuthorship W2607628579A5000441787 @default.
- W2607628579 hasAuthorship W2607628579A5013617878 @default.
- W2607628579 hasAuthorship W2607628579A5014920577 @default.
- W2607628579 hasAuthorship W2607628579A5018305440 @default.
- W2607628579 hasAuthorship W2607628579A5027134161 @default.
- W2607628579 hasAuthorship W2607628579A5027721650 @default.
- W2607628579 hasAuthorship W2607628579A5037249009 @default.
- W2607628579 hasAuthorship W2607628579A5038836690 @default.
- W2607628579 hasAuthorship W2607628579A5046775442 @default.
- W2607628579 hasAuthorship W2607628579A5048077073 @default.
- W2607628579 hasAuthorship W2607628579A5067291339 @default.
- W2607628579 hasAuthorship W2607628579A5080196380 @default.
- W2607628579 hasAuthorship W2607628579A5083487683 @default.
- W2607628579 hasAuthorship W2607628579A5090473887 @default.
- W2607628579 hasBestOaLocation W26076285791 @default.
- W2607628579 hasConcept C104317684 @default.
- W2607628579 hasConcept C121608353 @default.
- W2607628579 hasConcept C126322002 @default.