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- W2607635575 abstract "Consolidated periods of sleep during sensitive time points in development may be necessary for the maturation of the neurobiological systems that underlie species typical cognitive and social behaviors. Prairie voles (Microtus ochrogaster) are a highly social rodent species that form lifelong pair bonds with other individuals, thus providing an ideal rodent model to study how sleep shapes the development of social behavior. We selectively suppressed REM sleep in prairie vole pups during a sensitive post-natal period of development (post-natal days 14–21) by fragmenting sleep with gentle orbital shaking. Male and female animals were tested for social bonding and circadian running wheel activity as adults and underwent parvalbumin immunohistochemistry (IHC) followed by cell counting to quantify parvalbumin neurons in the somatosensory barrel fields. Early life sleep fragmentation prevented pair bond formation in male and female prairie voles and increased voluntary wheel running in males. Parvalbumin IHC revealed increased parvalbumin-immunoreactive cell counts in somatosensory barrel fields of sleep fragmented adults compared to non-sleep fragmented animals. This effect was more pronounced in males. Continuous sleep fragmentation from postnatal days 14–21 produced an adult behavioral phenotype reminiscent of some features of autism spectrum disorder, including impaired social bonding, hyperactivity, and a male bias in symptom severity. Studies utilizing this unique animal model will enhance our understanding of modifiable risk factors, such as sleep, that may contribute to atypical development of the brain and social behavior. VA CDA # IK2 BX002712, American Sleep Medicine Foundation, Brain & Behavior Foundation (NARSAD) Young Investigator Award #23700, Portland VA Research Foundation, Collins Medical Trust, NIH EXITO Institutional Core, # UL1GM118964, Florida State University, NIAAA T32 #5T32AA7468-29." @default.
- W2607635575 created "2017-05-05" @default.
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- W2607635575 date "2017-04-28" @default.
- W2607635575 modified "2023-09-24" @default.
- W2607635575 title "0047 EARLY POST-NATAL SLEEP FRAGMENTATION IMPAIRS SOCIAL DEVELOPMENT AND ALTERS PARVALBUMIN INTERNEURON EXPRESSION IN ADULT PRAIRIE VOLES" @default.
- W2607635575 doi "https://doi.org/10.1093/sleepj/zsx050.046" @default.
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