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• W2607662009 abstract "Wntless (Wls) is implicated in the Wnt signaling pathway by regulating the secretion of Wnt molecules. During brain development, Wls is expressed in the isthmic organizer (ISO) and rhombic lip (RL). Wls regulates Wnt1 secretion at the ISO which is required to induce midbrain–hindbrain structures. However, Wls function in the RL is not known. Here, we employed Nestin-cre to delete Wls specifically in the RL during mid-gestation. The loss-of-Wls leads to an abnormal RL during development and cerebellar vermis hypoplasia at birth. The Wls conditional knockout (cKO) has rudimentary foliation with an absence of Bergmann glia fibers in the external germinal layer (EGL). The Wls-cKO cerebellum also exhibits ectopia of several cell types and aberrations in granule cell organization. Finally, there is a loss of 85% of unipolar brush cells. From these findings, Wls-expressing cells in the rhombic lip are implicated in the orchestration of cerebellar development." @default.
• W2607662009 created "2017-05-05" @default.
• W2607662009 creator A5065416533 @default.
• W2607662009 creator A5080716293 @default.
• W2607662009 date "2017-06-01" @default.
• W2607662009 modified "2023-09-23" @default.
• W2607662009 title "Wls expression in the rhombic lip orchestrates the embryonic development of the mouse cerebellum" @default.
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• W2607662009 doi "https://doi.org/10.1016/j.neuroscience.2017.04.020" @default.
• W2607662009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28450263" @default.
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