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- W2607663857 abstract "Serum levels of adhesion molecules are associated with increased risk of cardiovascular disease (CVD). Obesity and OSA are associated with increased serum levels of adhesion molecules, but the interaction between them is unclear. Patients referred to the UBC Sleep Laboratory for a polysomnogram (PSG) for suspected OSA were recruited and provided a morning blood sample after PSG. 494 patients participated; mean age was 49.7 yrs, 323 were male, and mean AHI was 22.6/hr. In unadjusted analyses (Spearman’s coefficient), body mass index (BMI) was significantly associated with serum levels of the three adhesion molecules investigated (E-selectin, intracellular adhesion molecule ICAM, vascular cell adhesion molecule VCAM). AHI was significantly associated with E-selectin levels (Spearman’s= <.01) but not sICAM (Spearman’s= 0.31) or sVCAM (Spearman’s= .40). The relationships between E-selectin and BMI/AHI were further explored using linear regression. After adjusting for previous heart disease, smoking status, gender and age, both AHI (p=.01) and BMI (p=<.01) remained significant predictors. A multiplicative interaction between AHI and BMI was not found (p=.33). However, patients with both severe sleep apnea (AHI>30) and a BMI above the median (32 kg/m2) had elevated levels of E-selectin (55.43 ng/ml) compared to individuals who had either condition alone (50.39 ng/ml and 52.10 ng/ml), and ANOVA results suggest a significant difference between groups (F=<.01). BMI and AHI are significant predictors of E-selectin levels. Patients who were obese and had severe OSA had significantly higher E-selectin levels than those who had either condition alone. Further research is required to determine the clinical consequences of elevated levels of E-selectin associated with OSA and obesity. CIHR (Sleep Disordered Breathing Team Grant), VCHRI Scientist Award, BC Lung Association Operating Grant." @default.
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- W2607663857 date "2017-04-28" @default.
- W2607663857 modified "2023-09-23" @default.
- W2607663857 title "0452 THE INTERACTION BETWEEN OBSTRUCTIVE SLEEP APNEA (OSA) AND OBESITY ON SERUM LEVELS OF INFLAMMATORY ADHESION MOLECULES" @default.
- W2607663857 doi "https://doi.org/10.1093/sleepj/zsx050.451" @default.
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