FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607735498> ?p ?o ?g. }

• W2607735498 endingPage "194.e7" @default.
• W2607735498 startingPage "180" @default.
• W2607735498 abstract "Synaptic refinement is a critical step in nervous system maturation, requiring a carefully timed reorganization and refinement of neuronal connections. We have identified myrf-1 and myrf-2, two C. elegans homologs of Myrf family transcription factors, as key regulators of synaptic rewiring. MYRF-1 and its paralog MYRF-2 are functionally redundant specifically in synaptic rewiring. They co-exist in the same protein complex and act cooperatively to regulate synaptic rewiring. We find that the MYRF proteins localize to the ER membrane and that they are cleaved into active N-terminal fragments, which then translocate into the nucleus to drive synaptic rewiring. Overexpression of active forms of MYRF is sufficient to accelerate synaptic rewiring. MYRF-1 and MYRF-2 are the first genes identified to be indispensable for promoting synaptic rewiring in C. elegans. These findings reveal a molecular mechanism underlying synaptic rewiring and developmental circuit plasticity." @default.
• W2607735498 created "2017-05-05" @default.
• W2607735498 creator A5003152420 @default.
• W2607735498 creator A5011952332 @default.
• W2607735498 creator A5026639551 @default.
• W2607735498 creator A5031476166 @default.
• W2607735498 creator A5048085131 @default.
• W2607735498 creator A5057900758 @default.
• W2607735498 creator A5062310761 @default.
• W2607735498 creator A5063768132 @default.
• W2607735498 creator A5065131884 @default.
• W2607735498 creator A5085546073 @default.
• W2607735498 creator A5090384393 @default.
• W2607735498 date "2017-04-01" @default.
• W2607735498 modified "2023-10-16" @default.
• W2607735498 title "Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation" @default.
• W2607735498 cites W1480873359 @default.
• W2607735498 cites W1519556359 @default.
• W2607735498 cites W1549387196 @default.
• W2607735498 cites W1669755322 @default.
• W2607735498 cites W1816022152 @default.
• W2607735498 cites W1944127002 @default.
• W2607735498 cites W1950248588 @default.
• W2607735498 cites W1980317846 @default.
• W2607735498 cites W1982763652 @default.
• W2607735498 cites W1988664574 @default.
• W2607735498 cites W2003154381 @default.
• W2607735498 cites W2004692674 @default.
• W2607735498 cites W2013377646 @default.
• W2607735498 cites W2014022632 @default.
• W2607735498 cites W2034312395 @default.
• W2607735498 cites W2043486107 @default.
• W2607735498 cites W2060297895 @default.
• W2607735498 cites W2062403533 @default.
• W2607735498 cites W2072990016 @default.
• W2607735498 cites W2080464961 @default.
• W2607735498 cites W2085442517 @default.
• W2607735498 cites W2087459771 @default.
• W2607735498 cites W2095943622 @default.
• W2607735498 cites W2118721386 @default.
• W2607735498 cites W2119228805 @default.
• W2607735498 cites W2122458935 @default.
• W2607735498 cites W2134498383 @default.
• W2607735498 cites W2141940965 @default.
• W2607735498 cites W2150947848 @default.
• W2607735498 cites W2151498098 @default.
• W2607735498 cites W2153079301 @default.
• W2607735498 cites W2263324644 @default.
• W2607735498 cites W2468289707 @default.
• W2607735498 cites W2501957447 @default.
• W2607735498 cites W2518307773 @default.
• W2607735498 doi "https://doi.org/10.1016/j.devcel.2017.03.022" @default.
• W2607735498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5493483" @default.
• W2607735498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28441531" @default.
• W2607735498 hasPublicationYear "2017" @default.
• W2607735498 type Work @default.
• W2607735498 sameAs 2607735498 @default.
• W2607735498 citedByCount "24" @default.
• W2607735498 countsByYear W26077354982017 @default.
• W2607735498 countsByYear W26077354982018 @default.
• W2607735498 countsByYear W26077354982019 @default.
• W2607735498 countsByYear W26077354982020 @default.
• W2607735498 countsByYear W26077354982021 @default.
• W2607735498 countsByYear W26077354982022 @default.
• W2607735498 countsByYear W26077354982023 @default.
• W2607735498 crossrefType "journal-article" @default.
• W2607735498 hasAuthorship W2607735498A5003152420 @default.
• W2607735498 hasAuthorship W2607735498A5011952332 @default.
• W2607735498 hasAuthorship W2607735498A5026639551 @default.
• W2607735498 hasAuthorship W2607735498A5031476166 @default.
• W2607735498 hasAuthorship W2607735498A5048085131 @default.
• W2607735498 hasAuthorship W2607735498A5057900758 @default.
• W2607735498 hasAuthorship W2607735498A5062310761 @default.
• W2607735498 hasAuthorship W2607735498A5063768132 @default.
• W2607735498 hasAuthorship W2607735498A5065131884 @default.
• W2607735498 hasAuthorship W2607735498A5085546073 @default.
• W2607735498 hasAuthorship W2607735498A5090384393 @default.
• W2607735498 hasBestOaLocation W26077354981 @default.
• W2607735498 hasConcept C104317684 @default.
• W2607735498 hasConcept C169760540 @default.
• W2607735498 hasConcept C170493617 @default.
• W2607735498 hasConcept C2778944004 @default.
• W2607735498 hasConcept C54355233 @default.
• W2607735498 hasConcept C86339819 @default.
• W2607735498 hasConcept C86803240 @default.
• W2607735498 hasConcept C95444343 @default.
• W2607735498 hasConcept C98229152 @default.
• W2607735498 hasConceptScore W2607735498C104317684 @default.
• W2607735498 hasConceptScore W2607735498C169760540 @default.
• W2607735498 hasConceptScore W2607735498C170493617 @default.
• W2607735498 hasConceptScore W2607735498C2778944004 @default.
• W2607735498 hasConceptScore W2607735498C54355233 @default.
• W2607735498 hasConceptScore W2607735498C86339819 @default.
• W2607735498 hasConceptScore W2607735498C86803240 @default.
• W2607735498 hasConceptScore W2607735498C95444343 @default.
• W2607735498 hasConceptScore W2607735498C98229152 @default.
• W2607735498 hasFunder F4320306082 @default.
• W2607735498 hasFunder F4320321001 @default.

• next