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- W2607843061 abstract "Abstract Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness ( P =3.86 × 10 −8 ) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness ( P <0.001). A multilocus genetic score reflecting genetic variability of this signature is associated with memory performance ( P =0.0003) in 3,346 young and elderly healthy adults. The genomic location of the contributing methylation sites points to the involvement of specific immune system genes. The decomposition of blood methylome-wide patterns bears considerable potential for the study of brain-related traits." @default.
- W2607843061 created "2017-05-05" @default.
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- W2607843061 date "2017-04-26" @default.
- W2607843061 modified "2023-10-16" @default.
- W2607843061 title "A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory" @default.
- W2607843061 cites W1566415063 @default.
- W2607843061 cites W1588685142 @default.
- W2607843061 cites W1653971192 @default.
- W2607843061 cites W1714133886 @default.
- W2607843061 cites W1819436105 @default.
- W2607843061 cites W1963163807 @default.
- W2607843061 cites W1974047233 @default.
- W2607843061 cites W1975528145 @default.
- W2607843061 cites W1981260347 @default.
- W2607843061 cites W1987180785 @default.
- W2607843061 cites W1989369404 @default.
- W2607843061 cites W1989576509 @default.
- W2607843061 cites W1990300831 @default.
- W2607843061 cites W1990916340 @default.
- W2607843061 cites W1990958459 @default.
- W2607843061 cites W1993608602 @default.
- W2607843061 cites W1994239403 @default.
- W2607843061 cites W1996024251 @default.
- W2607843061 cites W2004349651 @default.
- W2607843061 cites W2010917685 @default.
- W2607843061 cites W2016113637 @default.
- W2607843061 cites W2016575029 @default.
- W2607843061 cites W2020031936 @default.
- W2607843061 cites W2020935778 @default.
- W2607843061 cites W2024306642 @default.
- W2607843061 cites W2033200260 @default.
- W2607843061 cites W2036284273 @default.
- W2607843061 cites W2037562549 @default.
- W2607843061 cites W2043399591 @default.
- W2607843061 cites W2046798829 @default.
- W2607843061 cites W2083225704 @default.
- W2607843061 cites W2086088557 @default.
- W2607843061 cites W2088477804 @default.
- W2607843061 cites W2094788831 @default.
- W2607843061 cites W2097524618 @default.
- W2607843061 cites W2099343472 @default.
- W2607843061 cites W2102093038 @default.
- W2607843061 cites W2104057213 @default.
- W2607843061 cites W2107060225 @default.
- W2607843061 cites W2110208125 @default.
- W2607843061 cites W2111884236 @default.
- W2607843061 cites W2113319997 @default.
- W2607843061 cites W2113359311 @default.
- W2607843061 cites W2113637769 @default.
- W2607843061 cites W2116565281 @default.
- W2607843061 cites W2116668074 @default.
- W2607843061 cites W2117621792 @default.
- W2607843061 cites W2121091193 @default.
- W2607843061 cites W2122739133 @default.
- W2607843061 cites W2124317383 @default.
- W2607843061 cites W2124655419 @default.
- W2607843061 cites W2128130893 @default.
- W2607843061 cites W2130523009 @default.
- W2607843061 cites W2136691282 @default.
- W2607843061 cites W2138848739 @default.
- W2607843061 cites W2140394554 @default.
- W2607843061 cites W2151721316 @default.
- W2607843061 cites W2152294954 @default.
- W2607843061 cites W2155120241 @default.
- W2607843061 cites W2155756772 @default.
- W2607843061 cites W2156826612 @default.
- W2607843061 cites W2157001435 @default.
- W2607843061 cites W2159536887 @default.
- W2607843061 cites W2161633633 @default.
- W2607843061 cites W2161922342 @default.
- W2607843061 cites W2163516107 @default.
- W2607843061 cites W2167021978 @default.
- W2607843061 cites W2167806431 @default.
- W2607843061 cites W2169353806 @default.
- W2607843061 cites W2478480648 @default.
- W2607843061 cites W2521139138 @default.
- W2607843061 cites W2559867197 @default.
- W2607843061 doi "https://doi.org/10.1038/ncomms15193" @default.
- W2607843061 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5414038" @default.
- W2607843061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28443631" @default.
- W2607843061 hasPublicationYear "2017" @default.