FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2607942301> ?p ?o ?g. }

• W2607942301 abstract "Oxidative stress may link to psychiatric disorders, and is being regarded as a plausible mechanism that can affect the regulation of these illnesses. The present study was undertaken to investigate the antidepressant and anxiolytic potential of A. hydaspica R. parkers. Brain oxidative stress enzyme levels were analyzed to correlate depression and stress with brain antioxidant status.Antidepressant and anxiolytic effect of methanol extract of A. hydaspica and its derived soluble fractions [n-hexane (AHH), ethyl-acetate (AHE), chloroform (AHC), n-butanol (AHB) and remaining aqueous fraction (AHA)] was investigated by using three behavioral models; the Forced swimming test, Tail suspension test and Elevated plus-maze test (EPM). Chronic unpredictable mild stress (CMS) was employed to induce stress in rats. AHM and AHE (200 mg/kg, p.o), fluoxetine (5 mg/kg, i.p) and diazepam (DZM) (1 mg/kg, p.o) were administered during the 7 day stress exposure period, and rats were assessed for antidepressant and anxiolytic behavioral despair paradigms. Antioxidant enzymes and oxidative stress markers were measured in brain tissue of depressed rats. Phytochemical analysis was done by GCMS experimentation.AHM and AHE (acute dose) significantly (p < 0.0001) reduced the immobility time and ameliorated climbing behavior as compared to the control in FST and TST, and similar to fluoxetine. AHM and AHE showed significant (p < 0.0001) anxiolytic potential in EPM, and comparable to DZM (1 mg/kg b.w., i.p). Significant decrease in antioxidant enzyme levels and increase in MDA, H2O2 and NO level were observed in stressed rats. AHM and AHE (for 7 days/CMS) significantly improved behavior in FST, TST and EPMT. Treatment also improved antioxidant enzyme level and controlled the oxidative stress markers in brain tissues. GCMS analysis indicated the presence of 10 different chemical constituents in A. hydaspica.The present study revealed that A. hydaspica exerts an antidepressant and anxiolytic effect by improving brain antioxidant status. The observed activities might be due to the presence of diverse phytochemicals." @default.
• W2607942301 created "2017-05-05" @default.
• W2607942301 creator A5026355032 @default.
• W2607942301 creator A5055041503 @default.
• W2607942301 creator A5079551997 @default.
• W2607942301 creator A5082237394 @default.
• W2607942301 date "2017-04-24" @default.
• W2607942301 modified "2023-10-14" @default.
• W2607942301 title "Anti-depressant and anxiolytic potential of Acacia hydaspica R. Parker aerial parts extract: Modulation of brain antioxidant enzyme status" @default.
• W2607942301 cites W130392180 @default.
• W2607942301 cites W1536654439 @default.
• W2607942301 cites W1545899030 @default.
• W2607942301 cites W1553725758 @default.
• W2607942301 cites W1561870426 @default.
• W2607942301 cites W1581414347 @default.
• W2607942301 cites W1599342152 @default.
• W2607942301 cites W1608114173 @default.
• W2607942301 cites W1889471557 @default.
• W2607942301 cites W1964160578 @default.
• W2607942301 cites W1965027767 @default.
• W2607942301 cites W1965787653 @default.
• W2607942301 cites W1971668349 @default.
• W2607942301 cites W1977430165 @default.
• W2607942301 cites W1990802251 @default.
• W2607942301 cites W2002725283 @default.
• W2607942301 cites W2005594217 @default.
• W2607942301 cites W2011886352 @default.
• W2607942301 cites W2013233086 @default.
• W2607942301 cites W2015778368 @default.
• W2607942301 cites W2030686396 @default.
• W2607942301 cites W2031561250 @default.
• W2607942301 cites W2033009565 @default.
• W2607942301 cites W2040299010 @default.
• W2607942301 cites W2043353183 @default.
• W2607942301 cites W2046962241 @default.
• W2607942301 cites W2050632824 @default.
• W2607942301 cites W2051854550 @default.
• W2607942301 cites W2056266253 @default.
• W2607942301 cites W2059554404 @default.
• W2607942301 cites W2070609814 @default.
• W2607942301 cites W2073092594 @default.
• W2607942301 cites W2074387820 @default.
• W2607942301 cites W2081363371 @default.
• W2607942301 cites W2087428438 @default.
• W2607942301 cites W2088638614 @default.
• W2607942301 cites W2091064555 @default.
• W2607942301 cites W2093540512 @default.
• W2607942301 cites W2097529540 @default.
• W2607942301 cites W2105705117 @default.
• W2607942301 cites W2110315026 @default.
• W2607942301 cites W2128263669 @default.
• W2607942301 cites W2150760153 @default.
• W2607942301 cites W2161450017 @default.
• W2607942301 cites W2167551595 @default.
• W2607942301 cites W2182586560 @default.
• W2607942301 cites W2298678407 @default.
• W2607942301 cites W2319075329 @default.
• W2607942301 cites W2486336747 @default.
• W2607942301 doi "https://doi.org/10.1186/s12906-017-1671-x" @default.
• W2607942301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5402641" @default.
• W2607942301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28438149" @default.
• W2607942301 hasPublicationYear "2017" @default.
• W2607942301 type Work @default.
• W2607942301 sameAs 2607942301 @default.
• W2607942301 citedByCount "17" @default.
• W2607942301 countsByYear W26079423012017 @default.
• W2607942301 countsByYear W26079423012018 @default.
• W2607942301 countsByYear W26079423012019 @default.
• W2607942301 countsByYear W26079423012020 @default.
• W2607942301 countsByYear W26079423012021 @default.
• W2607942301 countsByYear W26079423012022 @default.
• W2607942301 countsByYear W26079423012023 @default.
• W2607942301 crossrefType "journal-article" @default.
• W2607942301 hasAuthorship W2607942301A5026355032 @default.
• W2607942301 hasAuthorship W2607942301A5055041503 @default.
• W2607942301 hasAuthorship W2607942301A5079551997 @default.
• W2607942301 hasAuthorship W2607942301A5082237394 @default.
• W2607942301 hasBestOaLocation W26079423011 @default.
• W2607942301 hasConcept C118552586 @default.
• W2607942301 hasConcept C126322002 @default.
• W2607942301 hasConcept C134018914 @default.
• W2607942301 hasConcept C136569192 @default.
• W2607942301 hasConcept C142724271 @default.
• W2607942301 hasConcept C170493617 @default.
• W2607942301 hasConcept C173586616 @default.
• W2607942301 hasConcept C185592680 @default.
• W2607942301 hasConcept C204787440 @default.
• W2607942301 hasConcept C2775864247 @default.
• W2607942301 hasConcept C2776134451 @default.
• W2607942301 hasConcept C2776151105 @default.
• W2607942301 hasConcept C2776175493 @default.
• W2607942301 hasConcept C2777765862 @default.
• W2607942301 hasConcept C2778004101 @default.
• W2607942301 hasConcept C2779145073 @default.
• W2607942301 hasConcept C2779177272 @default.
• W2607942301 hasConcept C2781001258 @default.
• W2607942301 hasConcept C2781161787 @default.
• W2607942301 hasConcept C2908855275 @default.
• W2607942301 hasConcept C31903555 @default.
• W2607942301 hasConcept C55493867 @default.

• next