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• W2608035650 abstract "Hydrogen sulfide (H 2 S), independently of any specific transporters, has a number of biological effects on the cardiovascular system. However, until now, the detailed mechanism of H 2 S was not clear. Recently, a novel post‐translational modification induced by H 2 S, named S‐sulfhydration, has been proposed. S‐sulfhydration is the chemical modification of specific cysteine residues of target proteins by H 2 S. There are several methods for detecting S‐sulfhydration, such as the modified biotin switch assay, maleimide assay with fluorescent thiol modifying regents, tag‐switch method and mass spectrometry. H 2 S induces S‐sulfhydration on enzymes or receptors (such as p66Shc, phospholamban, protein tyrosine phosphatase 1B, mitogen‐activated extracellular signal‐regulated kinase 1 and ATP synthase subunit α), transcription factors (such as specific protein‐1, kelch‐like ECH‐associating protein 1, NF‐κB and interferon regulatory factor‐1), and ion channels (such as voltage‐activated Ca 2+ channels, transient receptor potential channels and ATP‐sensitive K + channels) in the cardiovascular system. Although significant progress has been achieved in delineating the role of protein S‐sulfhydration by H 2 S in the cardiovascular system, more proteins with detailed cysteine sites of S‐sulfhydration as well as physiological function need to be investigated in further studies. This review mainly summarizes the role and possible mechanism of S‐sulfhydration in the cardiovascular system. The S‐sulfhydrated proteins may be potential novel targets for therapeutic intervention and drug design in the cardiovascular system, which may accelerate the development and application of H 2 S‐related drugs in the future. Linked Articles This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc" @default.
• W2608035650 created "2017-05-05" @default.
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• W2608035650 date "2017-05-24" @default.
• W2608035650 modified "2023-10-18" @default.
• W2608035650 title "Protein S-sulfhydration by hydrogen sulfide in cardiovascular system" @default.
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• W2608035650 doi "https://doi.org/10.1111/bph.13825" @default.
• W2608035650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5866969" @default.

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