FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2608038868> ?p ?o ?g. }

• W2608038868 endingPage "807" @default.
• W2608038868 startingPage "798" @default.
• W2608038868 abstract "Mesenchymal stromal cells (MSCs) are used as experimental immunotherapy. Extensive culture expansion is necessary to obtain clinically relevant cell numbers, although the impact on MSCs stability and function is unclear. This study investigated the effects of long-term in vitro expansion on the stability and function of MSCs.Human bone marrow-derived (bmMSCs) and umbilical cord-derived (ucMSCs) MSCs were in vitro expanded. During expansion, their proliferative capacity was examined. At passages 4, 8 and 12, analyses were performed to investigate the ploidy, metabolic stability, telomere length and immunophenotype. In addition, their potential to suppress lymphocyte proliferation and susceptibility to natural killer cell lysis was examined.BmMSCs and ucMSCs showed decreasing proliferative capacity over time, while their telomere lengths and mitochondrial activity remained stable. Percentage of aneuploidy in cultures was unchanged after expansion. Furthermore, expression of MSC markers and markers associated with stress or aging remained unchanged. Reduced capacity to suppress CD4 and CD8 T-cell proliferation was observed for passage 8 and 12 bmMSCs and ucMSCs. Finally, susceptibility of bmMSCs and ucMSCs to NK-cell lysis remained stable.We showed that after long-term expansion, phenotype of bmMSCs and ucMSCs remains stable and cells exhibit similar immunogenic properties compared with lower passage cells. However, immunosuppressive properties of MSCs are reduced. These findings reveal the consequences of application of higher passage MSCs in the clinic, which will help increase the yield of therapeutic MSCs but may interfere with their efficacy." @default.
• W2608038868 created "2017-05-05" @default.
• W2608038868 creator A5012450849 @default.
• W2608038868 creator A5016286147 @default.
• W2608038868 creator A5019473153 @default.
• W2608038868 creator A5029079538 @default.
• W2608038868 creator A5044832887 @default.
• W2608038868 creator A5051094495 @default.
• W2608038868 creator A5064171895 @default.
• W2608038868 creator A5065236703 @default.
• W2608038868 creator A5068909335 @default.
• W2608038868 creator A5079480357 @default.
• W2608038868 creator A5091419246 @default.
• W2608038868 date "2017-07-01" @default.
• W2608038868 modified "2023-09-29" @default.
• W2608038868 title "Aging of bone marrow– and umbilical cord–derived mesenchymal stromal cells during expansion" @default.
• W2608038868 cites W1643675502 @default.
• W2608038868 cites W1804670053 @default.
• W2608038868 cites W1813186957 @default.
• W2608038868 cites W1968255500 @default.
• W2608038868 cites W1973770168 @default.
• W2608038868 cites W1983673827 @default.
• W2608038868 cites W1998461585 @default.
• W2608038868 cites W2034656280 @default.
• W2608038868 cites W2035976926 @default.
• W2608038868 cites W2045802318 @default.
• W2608038868 cites W2058458618 @default.
• W2608038868 cites W2068812935 @default.
• W2608038868 cites W2075933572 @default.
• W2608038868 cites W2082586271 @default.
• W2608038868 cites W2088581630 @default.
• W2608038868 cites W2095196199 @default.
• W2608038868 cites W2102449868 @default.
• W2608038868 cites W2103893610 @default.
• W2608038868 cites W2107538726 @default.
• W2608038868 cites W2113071846 @default.
• W2608038868 cites W2115788075 @default.
• W2608038868 cites W2126134953 @default.
• W2608038868 cites W2129839972 @default.
• W2608038868 cites W2133810389 @default.
• W2608038868 cites W2138946470 @default.
• W2608038868 cites W2139147346 @default.
• W2608038868 cites W2140099354 @default.
• W2608038868 cites W2160666118 @default.
• W2608038868 cites W2166106062 @default.
• W2608038868 cites W2524881570 @default.
• W2608038868 doi "https://doi.org/10.1016/j.jcyt.2017.03.071" @default.
• W2608038868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28462821" @default.
• W2608038868 hasPublicationYear "2017" @default.
• W2608038868 type Work @default.
• W2608038868 sameAs 2608038868 @default.
• W2608038868 citedByCount "61" @default.
• W2608038868 countsByYear W26080388682017 @default.
• W2608038868 countsByYear W26080388682018 @default.
• W2608038868 countsByYear W26080388682019 @default.
• W2608038868 countsByYear W26080388682020 @default.
• W2608038868 countsByYear W26080388682021 @default.
• W2608038868 countsByYear W26080388682022 @default.
• W2608038868 countsByYear W26080388682023 @default.
• W2608038868 crossrefType "journal-article" @default.
• W2608038868 hasAuthorship W2608038868A5012450849 @default.
• W2608038868 hasAuthorship W2608038868A5016286147 @default.
• W2608038868 hasAuthorship W2608038868A5019473153 @default.
• W2608038868 hasAuthorship W2608038868A5029079538 @default.
• W2608038868 hasAuthorship W2608038868A5044832887 @default.
• W2608038868 hasAuthorship W2608038868A5051094495 @default.
• W2608038868 hasAuthorship W2608038868A5064171895 @default.
• W2608038868 hasAuthorship W2608038868A5065236703 @default.
• W2608038868 hasAuthorship W2608038868A5068909335 @default.
• W2608038868 hasAuthorship W2608038868A5079480357 @default.
• W2608038868 hasAuthorship W2608038868A5091419246 @default.
• W2608038868 hasConcept C10882517 @default.
• W2608038868 hasConcept C137061746 @default.
• W2608038868 hasConcept C1491633281 @default.
• W2608038868 hasConcept C167672396 @default.
• W2608038868 hasConcept C16930146 @default.
• W2608038868 hasConcept C177336024 @default.
• W2608038868 hasConcept C196166836 @default.
• W2608038868 hasConcept C198826908 @default.
• W2608038868 hasConcept C202751555 @default.
• W2608038868 hasConcept C203014093 @default.
• W2608038868 hasConcept C2776955114 @default.
• W2608038868 hasConcept C2780007613 @default.
• W2608038868 hasConcept C28328180 @default.
• W2608038868 hasConcept C502942594 @default.
• W2608038868 hasConcept C54355233 @default.
• W2608038868 hasConcept C552990157 @default.
• W2608038868 hasConcept C553184892 @default.
• W2608038868 hasConcept C86803240 @default.
• W2608038868 hasConcept C8891405 @default.
• W2608038868 hasConcept C95444343 @default.
• W2608038868 hasConceptScore W2608038868C10882517 @default.
• W2608038868 hasConceptScore W2608038868C137061746 @default.
• W2608038868 hasConceptScore W2608038868C1491633281 @default.
• W2608038868 hasConceptScore W2608038868C167672396 @default.
• W2608038868 hasConceptScore W2608038868C16930146 @default.
• W2608038868 hasConceptScore W2608038868C177336024 @default.
• W2608038868 hasConceptScore W2608038868C196166836 @default.

• next