FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2608181639> ?p ?o ?g. }

• W2608181639 endingPage "e0176693" @default.
• W2608181639 startingPage "e0176693" @default.
• W2608181639 abstract "Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was to develop a robust and accurate method of MRI-guided radiotherapy (MR-IGRT) delivery to abdominal targets in the mouse.A multimodality cradle was developed for providing subject immobilisation and its performance was evaluated. Whilst CT was still used for dose calculations, target identification was based on MRI. Each step of the radiotherapy planning procedure was validated initially in vitro using BANG gel dosimeters. Subsequently, MR-IGRT of normal adrenal glands with a size-matched collimated beam was performed. Additionally, the SK-N-SH neuroblastoma xenograft model and the transgenic KPC model of pancreatic ductal adenocarcinoma were used to demonstrate the applicability of our methods for the accurate delivery of radiation to CT-invisible abdominal tumours.The BANG gel phantoms demonstrated a targeting efficiency error of 0.56 ± 0.18 mm. The in vivo stability tests of body motion during MR-IGRT and the associated cradle transfer showed that the residual body movements are within this MR-IGRT targeting error. Accurate MR-IGRT of the normal adrenal glands with a size-matched collimated beam was confirmed by γH2AX staining. Regression in tumour volume was observed almost immediately post MR-IGRT in the neuroblastoma model, further demonstrating accuracy of x-ray delivery. Finally, MR-IGRT in the KPC model facilitated precise contouring and comparison of different treatment plans and radiotherapy dose distributions not only to the intra-abdominal tumour but also to the organs at risk.This is, to our knowledge, the first study to demonstrate preclinical MR-IGRT in intra-abdominal organs. The proposed MR-IGRT method presents a state-of-the-art solution to enabling robust, accurate and efficient targeting of extracranial organs in the mouse and can operate with a sufficiently high throughput to allow fractionated treatments to be given." @default.
• W2608181639 created "2017-05-05" @default.
• W2608181639 creator A5001440882 @default.
• W2608181639 creator A5005540802 @default.
• W2608181639 creator A5017494947 @default.
• W2608181639 creator A5017932546 @default.
• W2608181639 creator A5021186593 @default.
• W2608181639 creator A5025029895 @default.
• W2608181639 creator A5025966737 @default.
• W2608181639 creator A5028206592 @default.
• W2608181639 creator A5032938289 @default.
• W2608181639 creator A5043131704 @default.
• W2608181639 creator A5051480732 @default.
• W2608181639 creator A5055691162 @default.
• W2608181639 creator A5059449850 @default.
• W2608181639 creator A5061494035 @default.
• W2608181639 creator A5070693957 @default.
• W2608181639 creator A5071554347 @default.
• W2608181639 creator A5074404084 @default.
• W2608181639 creator A5079428721 @default.
• W2608181639 creator A5091168823 @default.
• W2608181639 creator A5091835801 @default.
• W2608181639 creator A5080338096 @default.
• W2608181639 date "2017-04-28" @default.
• W2608181639 modified "2023-10-05" @default.
• W2608181639 title "An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse" @default.
• W2608181639 cites W122927108 @default.
• W2608181639 cites W1258890488 @default.
• W2608181639 cites W1983222150 @default.
• W2608181639 cites W1983592655 @default.
• W2608181639 cites W1983882042 @default.
• W2608181639 cites W1992995822 @default.
• W2608181639 cites W1997817074 @default.
• W2608181639 cites W2012885850 @default.
• W2608181639 cites W2019230260 @default.
• W2608181639 cites W2019600368 @default.
• W2608181639 cites W2022672373 @default.
• W2608181639 cites W2028435743 @default.
• W2608181639 cites W2036420841 @default.
• W2608181639 cites W2041986914 @default.
• W2608181639 cites W2050624834 @default.
• W2608181639 cites W2050718666 @default.
• W2608181639 cites W2051242091 @default.
• W2608181639 cites W2066135299 @default.
• W2608181639 cites W2067396914 @default.
• W2608181639 cites W2077240915 @default.
• W2608181639 cites W2089344167 @default.
• W2608181639 cites W2092761128 @default.
• W2608181639 cites W2099540110 @default.
• W2608181639 cites W2108475931 @default.
• W2608181639 cites W2127890285 @default.
• W2608181639 cites W2131789839 @default.
• W2608181639 cites W2150400603 @default.
• W2608181639 cites W2161869976 @default.
• W2608181639 cites W2184245120 @default.
• W2608181639 cites W2201711371 @default.
• W2608181639 cites W2518066305 @default.
• W2608181639 cites W4377077308 @default.
• W2608181639 doi "https://doi.org/10.1371/journal.pone.0176693" @default.
• W2608181639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5409175" @default.
• W2608181639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28453537" @default.
• W2608181639 hasPublicationYear "2017" @default.
• W2608181639 type Work @default.
• W2608181639 sameAs 2608181639 @default.
• W2608181639 citedByCount "12" @default.
• W2608181639 countsByYear W26081816392017 @default.
• W2608181639 countsByYear W26081816392018 @default.
• W2608181639 countsByYear W26081816392019 @default.
• W2608181639 countsByYear W26081816392021 @default.
• W2608181639 countsByYear W26081816392022 @default.
• W2608181639 countsByYear W26081816392023 @default.
• W2608181639 crossrefType "journal-article" @default.
• W2608181639 hasAuthorship W2608181639A5001440882 @default.
• W2608181639 hasAuthorship W2608181639A5005540802 @default.
• W2608181639 hasAuthorship W2608181639A5017494947 @default.
• W2608181639 hasAuthorship W2608181639A5017932546 @default.
• W2608181639 hasAuthorship W2608181639A5021186593 @default.
• W2608181639 hasAuthorship W2608181639A5025029895 @default.
• W2608181639 hasAuthorship W2608181639A5025966737 @default.
• W2608181639 hasAuthorship W2608181639A5028206592 @default.
• W2608181639 hasAuthorship W2608181639A5032938289 @default.
• W2608181639 hasAuthorship W2608181639A5043131704 @default.
• W2608181639 hasAuthorship W2608181639A5051480732 @default.
• W2608181639 hasAuthorship W2608181639A5055691162 @default.
• W2608181639 hasAuthorship W2608181639A5059449850 @default.
• W2608181639 hasAuthorship W2608181639A5061494035 @default.
• W2608181639 hasAuthorship W2608181639A5070693957 @default.
• W2608181639 hasAuthorship W2608181639A5071554347 @default.
• W2608181639 hasAuthorship W2608181639A5074404084 @default.
• W2608181639 hasAuthorship W2608181639A5079428721 @default.
• W2608181639 hasAuthorship W2608181639A5080338096 @default.
• W2608181639 hasAuthorship W2608181639A5091168823 @default.
• W2608181639 hasAuthorship W2608181639A5091835801 @default.
• W2608181639 hasBestOaLocation W26081816391 @default.
• W2608181639 hasConcept C121684516 @default.
• W2608181639 hasConcept C126838900 @default.
• W2608181639 hasConcept C201645570 @default.
• W2608181639 hasConcept C2779104521 @default.

• next