FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2608356044> ?p ?o ?g. }

• W2608356044 abstract "Abstract Biological substances based on proteins, including vaccines, antibodies, and enzymes, typically degrade at room temperature over time due to denaturation, as proteins unfold with loss of secondary and tertiary structure. Their storage and distribution therefore relies on a “cold chain” of continuous refrigeration; this is costly and not always effective, as any break in the chain leads to rapid loss of effectiveness and potency. Efforts have been made to make vaccines thermally stable using treatments including freeze-drying (lyophilisation), biomineralisation, and encapsulation in sugar glass and organic polymers. Here for the first time we show that proteins can be enclosed in a deposited silica “cage”, rendering them stable against denaturing thermal treatment and long-term ambient-temperature storage, and subsequently released into solution with their structure and function intact. This “ensilication” method produces a storable solid protein-loaded material without the need for desiccation or freeze-drying. Ensilication offers the prospect of a solution to the “cold chain” problem for biological materials, in particular for vaccines." @default.
• W2608356044 created "2017-05-05" @default.
• W2608356044 creator A5001393032 @default.
• W2608356044 creator A5011880991 @default.
• W2608356044 creator A5024552542 @default.
• W2608356044 creator A5026032024 @default.
• W2608356044 creator A5027439767 @default.
• W2608356044 creator A5032712806 @default.
• W2608356044 creator A5046798572 @default.
• W2608356044 creator A5051160190 @default.
• W2608356044 creator A5078289414 @default.
• W2608356044 creator A5080302708 @default.
• W2608356044 creator A5085037881 @default.
• W2608356044 date "2017-04-24" @default.
• W2608356044 modified "2023-10-14" @default.
• W2608356044 title "Thermal stability, storage and release of proteins with tailored fit in silica" @default.
• W2608356044 cites W1534324490 @default.
• W2608356044 cites W1591227306 @default.
• W2608356044 cites W1965833087 @default.
• W2608356044 cites W1970502264 @default.
• W2608356044 cites W1985098294 @default.
• W2608356044 cites W1992045220 @default.
• W2608356044 cites W1993043346 @default.
• W2608356044 cites W2001311725 @default.
• W2608356044 cites W2003021105 @default.
• W2608356044 cites W2005004332 @default.
• W2608356044 cites W2006517749 @default.
• W2608356044 cites W2011736607 @default.
• W2608356044 cites W2023440735 @default.
• W2608356044 cites W2030048712 @default.
• W2608356044 cites W2035896672 @default.
• W2608356044 cites W2039370171 @default.
• W2608356044 cites W2062010593 @default.
• W2608356044 cites W2087403923 @default.
• W2608356044 cites W2089740770 @default.
• W2608356044 cites W2094322025 @default.
• W2608356044 cites W2122802861 @default.
• W2608356044 cites W2134552328 @default.
• W2608356044 cites W2140446852 @default.
• W2608356044 cites W2152425447 @default.
• W2608356044 cites W2163892360 @default.
• W2608356044 cites W2319905575 @default.
• W2608356044 cites W99992179 @default.
• W2608356044 doi "https://doi.org/10.1038/srep46568" @default.
• W2608356044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5402271" @default.
• W2608356044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28436442" @default.
• W2608356044 hasPublicationYear "2017" @default.
• W2608356044 type Work @default.
• W2608356044 sameAs 2608356044 @default.
• W2608356044 citedByCount "33" @default.
• W2608356044 countsByYear W26083560442018 @default.
• W2608356044 countsByYear W26083560442019 @default.
• W2608356044 countsByYear W26083560442020 @default.
• W2608356044 countsByYear W26083560442021 @default.
• W2608356044 countsByYear W26083560442022 @default.
• W2608356044 countsByYear W26083560442023 @default.
• W2608356044 crossrefType "journal-article" @default.
• W2608356044 hasAuthorship W2608356044A5001393032 @default.
• W2608356044 hasAuthorship W2608356044A5011880991 @default.
• W2608356044 hasAuthorship W2608356044A5024552542 @default.
• W2608356044 hasAuthorship W2608356044A5026032024 @default.
• W2608356044 hasAuthorship W2608356044A5027439767 @default.
• W2608356044 hasAuthorship W2608356044A5032712806 @default.
• W2608356044 hasAuthorship W2608356044A5046798572 @default.
• W2608356044 hasAuthorship W2608356044A5051160190 @default.
• W2608356044 hasAuthorship W2608356044A5078289414 @default.
• W2608356044 hasAuthorship W2608356044A5080302708 @default.
• W2608356044 hasAuthorship W2608356044A5085037881 @default.
• W2608356044 hasBestOaLocation W26083560441 @default.
• W2608356044 hasConcept C121684516 @default.
• W2608356044 hasConcept C127413603 @default.
• W2608356044 hasConcept C178790620 @default.
• W2608356044 hasConcept C185592680 @default.
• W2608356044 hasConcept C192562407 @default.
• W2608356044 hasConcept C205711294 @default.
• W2608356044 hasConcept C2780114722 @default.
• W2608356044 hasConcept C2988375501 @default.
• W2608356044 hasConcept C31903555 @default.
• W2608356044 hasConcept C41008148 @default.
• W2608356044 hasConcept C42360764 @default.
• W2608356044 hasConcept C43617362 @default.
• W2608356044 hasConcept C50402729 @default.
• W2608356044 hasConcept C521977710 @default.
• W2608356044 hasConcept C55493867 @default.
• W2608356044 hasConcept C59061564 @default.
• W2608356044 hasConcept C59822182 @default.
• W2608356044 hasConcept C69907114 @default.
• W2608356044 hasConcept C78519656 @default.
• W2608356044 hasConcept C84199377 @default.
• W2608356044 hasConcept C86803240 @default.
• W2608356044 hasConceptScore W2608356044C121684516 @default.
• W2608356044 hasConceptScore W2608356044C127413603 @default.
• W2608356044 hasConceptScore W2608356044C178790620 @default.
• W2608356044 hasConceptScore W2608356044C185592680 @default.
• W2608356044 hasConceptScore W2608356044C192562407 @default.
• W2608356044 hasConceptScore W2608356044C205711294 @default.
• W2608356044 hasConceptScore W2608356044C2780114722 @default.
• W2608356044 hasConceptScore W2608356044C2988375501 @default.
• W2608356044 hasConceptScore W2608356044C31903555 @default.
• W2608356044 hasConceptScore W2608356044C41008148 @default.

• next