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- W2608380921 abstract "A new series of oxazolones and triazinones were designed and synthesized and evaluated against both COX-1 and COX-2 enzymes. Full structure elucidation of the new derivatives was performed using microanalyses, IR, 1H NMR, 13C NMR and mass spectra. Most of the derivatives showed good inhibitory activity against COX-2 enzyme specifically compounds IIIc, IIIe, IVd and IVg with IC50 values 0.024, 0.019, 0.011 and 0.014µM compared to celecoxib as reference drug with IC50 value of 0.05µM. Altogether, these results indicate that these derivatives can be effective anti-inflammatory agents." @default.
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- W2608380921 date "2017-06-01" @default.
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- W2608380921 title "Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors" @default.
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- W2608380921 doi "https://doi.org/10.1016/j.bioorg.2017.04.012" @default.
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