Matches in SemOpenAlex for { <https://semopenalex.org/work/W2608410950> ?p ?o ?g. }
- W2608410950 abstract "Abstract Whipworms are parasitic nematodes that live in the gut of more than 500 million people worldwide. Due to the difficulty in obtaining parasite material, the mouse whipworm Trichuris muris has been extensively used as a model to study human whipworm infections. These nematodes secrete a multitude of compounds that interact with host tissues where they orchestrate a parasitic existence. Herein we provide the first comprehensive characterisation of the excretory/secretory products of T. muris. We identify 148 proteins secreted by T. muris and show for the first time that the mouse whipworm secretes exosome-like extracellular vesicles (EVs) that can interact with host cells. We use an Optiprep ® gradient to purify the EVs, highlighting the suitability of this method for purifying EVs secreted by a parasitic nematode. We also characterise the proteomic and genomic content of the EVs, identifying >350 proteins, 56 miRNAs (22 novel) and 475 full-length mRNA transcripts mapping to T. muris gene models. Many of the miRNAs putatively mapped to mouse genes involved in regulation of inflammation, implying a role in parasite-driven immunomodulation. In addition, for the first time to our knowledge, we use colonic organoids to demonstrate the internalisation of parasite EVs by host cells. Understanding how parasites interact with their host is crucial to develop new control measures. This first characterisation of the proteins and EVs secreted by T. muris provides important information on whipworm-host communication and forms the basis for future studies." @default.
- W2608410950 created "2017-05-05" @default.
- W2608410950 creator A5001125098 @default.
- W2608410950 creator A5027260606 @default.
- W2608410950 creator A5035359895 @default.
- W2608410950 creator A5071410567 @default.
- W2608410950 creator A5072690991 @default.
- W2608410950 creator A5083935076 @default.
- W2608410950 creator A5084069127 @default.
- W2608410950 date "2017-04-19" @default.
- W2608410950 modified "2023-09-24" @default.
- W2608410950 title "Characterisation of Trichuris muris secreted proteins and extracellular vesicles provides new insights into host-parasite communication" @default.
- W2608410950 cites W1591556006 @default.
- W2608410950 cites W1722029454 @default.
- W2608410950 cites W1800636431 @default.
- W2608410950 cites W1881130638 @default.
- W2608410950 cites W1926241811 @default.
- W2608410950 cites W1970870994 @default.
- W2608410950 cites W1974116356 @default.
- W2608410950 cites W1976641312 @default.
- W2608410950 cites W1984276265 @default.
- W2608410950 cites W1989277387 @default.
- W2608410950 cites W1996475963 @default.
- W2608410950 cites W1997114875 @default.
- W2608410950 cites W1997975213 @default.
- W2608410950 cites W2002513358 @default.
- W2608410950 cites W2003343932 @default.
- W2608410950 cites W2008627178 @default.
- W2608410950 cites W2009927945 @default.
- W2608410950 cites W2016075015 @default.
- W2608410950 cites W2019158910 @default.
- W2608410950 cites W2021393510 @default.
- W2608410950 cites W2026155187 @default.
- W2608410950 cites W2029849110 @default.
- W2608410950 cites W2034399323 @default.
- W2608410950 cites W2035861820 @default.
- W2608410950 cites W2037993016 @default.
- W2608410950 cites W2038944440 @default.
- W2608410950 cites W2039138854 @default.
- W2608410950 cites W2040126655 @default.
- W2608410950 cites W2041031948 @default.
- W2608410950 cites W2049356233 @default.
- W2608410950 cites W2055032691 @default.
- W2608410950 cites W2055313665 @default.
- W2608410950 cites W2069649392 @default.
- W2608410950 cites W2076637458 @default.
- W2608410950 cites W2077327925 @default.
- W2608410950 cites W2086704388 @default.
- W2608410950 cites W2087888043 @default.
- W2608410950 cites W2094201044 @default.
- W2608410950 cites W2097761110 @default.
- W2608410950 cites W2102201378 @default.
- W2608410950 cites W2118220671 @default.
- W2608410950 cites W2120456037 @default.
- W2608410950 cites W2122517838 @default.
- W2608410950 cites W2124373678 @default.
- W2608410950 cites W2124806393 @default.
- W2608410950 cites W2125198788 @default.
- W2608410950 cites W2128881579 @default.
- W2608410950 cites W2130305733 @default.
- W2608410950 cites W2131631319 @default.
- W2608410950 cites W2137900362 @default.
- W2608410950 cites W2145383478 @default.
- W2608410950 cites W2147836597 @default.
- W2608410950 cites W2151211884 @default.
- W2608410950 cites W2152426066 @default.
- W2608410950 cites W2155271571 @default.
- W2608410950 cites W2155441983 @default.
- W2608410950 cites W2156171525 @default.
- W2608410950 cites W2157257094 @default.
- W2608410950 cites W2169456326 @default.
- W2608410950 cites W2172246547 @default.
- W2608410950 cites W2176750505 @default.
- W2608410950 cites W2179282661 @default.
- W2608410950 cites W2287258646 @default.
- W2608410950 cites W2318807815 @default.
- W2608410950 cites W2326857034 @default.
- W2608410950 cites W2529143558 @default.
- W2608410950 cites W2542233234 @default.
- W2608410950 cites W2548555233 @default.
- W2608410950 cites W2554014031 @default.
- W2608410950 cites W2559466477 @default.
- W2608410950 cites W2568027424 @default.
- W2608410950 cites W2584102880 @default.
- W2608410950 cites W2615324154 @default.
- W2608410950 cites W4252232449 @default.
- W2608410950 doi "https://doi.org/10.1101/128629" @default.
- W2608410950 hasPublicationYear "2017" @default.
- W2608410950 type Work @default.
- W2608410950 sameAs 2608410950 @default.
- W2608410950 citedByCount "2" @default.
- W2608410950 countsByYear W26084109502017 @default.
- W2608410950 crossrefType "posted-content" @default.
- W2608410950 hasAuthorship W2608410950A5001125098 @default.
- W2608410950 hasAuthorship W2608410950A5027260606 @default.
- W2608410950 hasAuthorship W2608410950A5035359895 @default.
- W2608410950 hasAuthorship W2608410950A5071410567 @default.
- W2608410950 hasAuthorship W2608410950A5072690991 @default.
- W2608410950 hasAuthorship W2608410950A5083935076 @default.
- W2608410950 hasAuthorship W2608410950A5084069127 @default.